SPDR S&P Pharmaceuticals ETF (XPH) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with XPH. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to XPH
XPH charges 0.35% annually. There are 8 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 42.10B | Dec 1998 | XPH vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | XPH vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 20.40B | Jan 2004 | XPH vs VHT | |
| VanEck Healthcare TruSector ETF | 0.10% | 850.50K | Apr 2026 | XPH vs TRUH | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 933.15M | Nov 2025 | XPH vs PBPH |
Best Risk-Adjusted Alternatives to XPH
XPH has a PortfoliosLab risk / return rank of 94. There are 5 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 47.80M | Dec 2014 | XPH vs BBC | |
| iShares U.S. Pharmaceuticals ETF | 95 | 1.65B | May 2006 | XPH vs IHE | |
| First Trust Nasdaq Pharmaceuticals ETF | 95 | 911.09M | Sep 2016 | XPH vs FTXH | |
| ALPS Medical Breakthroughs ETF | 95 | 201.57M | Dec 2014 | XPH vs SBIO | |
| Invesco Dynamic Pharmaceuticals ETF | 94 | 472.10M | Jun 2005 | XPH vs PJP |
Top Performing XPH Alternatives (YTD)
XPH is at 22.08% YTD. There are 8 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 36.76%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 36.76% | 1.73B | Oct 2014 | XPH vs ARKG | |
| AdvisorShares Psychedelics ETF | 36.69% | 48.53M | Sep 2021 | XPH vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 28.89% | 7.27M | Dec 2025 | XPH vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 27.03% | 47.80M | Dec 2014 | XPH vs BBC | |
| SPDR S&P Health Care Services ETF | 25.67% | 206.72M | Sep 2011 | XPH vs XHS |
Lowest Volatility Alternatives to XPH
XPH has 22.59% 1-year volatility. There are 44 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | XPH vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | XPH vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.66% | 10.09M | Jun 2007 | XPH vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.75% | 21.55M | Jul 2025 | XPH vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 10.92% | 982.35K | Apr 2026 | XPH vs MHIP |
Lowest Drawdown Alternatives to XPH
XPH has a 1-year max drawdown of -11.97%. There are 29 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | XPH vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.20% | 10.09M | Jun 2007 | XPH vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 911.09M | Sep 2016 | XPH vs FTXH | |
| State Street Health Care Select Sector SPDR Premiu... | -8.14% | 21.55M | Jul 2025 | XPH vs XLVI | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 75.06M | Jun 2021 | XPH vs IBBQ |
Other ETFs from State Street
The 10 most viewed State Street ETFs shown here include SPY, GLD, XLK and span 10 categories. AUM among these funds goes as high as $789B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| State Street SPDR S&P 500 ETF | S&P 500 | 78 | 11.70% | 789.06B | Jan 1993 | XPH vs SPY | |
| SPDR Gold Shares | Gold, Precious Metals | 28 | -6.21% | 130.32B | Nov 2004 | XPH vs GLD | |
| State Street Technology Select Sector SPDR ETF | Technology Equities | 62 | 23.97% | 115.56B | Dec 1998 | XPH vs XLK | |
| State Street SPDR Portfolio S&P 500 Growth ETF | S&P 500, Large Cap Growth Equities | 53 | 12.43% | 51.09B | Sep 2000 | XPH vs SPYG | |
| State Street SPDR Portfolio S&P 500 ETF | S&P 500 | 78 | 11.77% | 160.81B | Nov 2005 | XPH vs SPYM | |
| State Street SPDR Portfolio S&P 500 High Dividend ... | S&P 500, Dividend | 81 | 17.73% | 8.75B | Oct 2015 | XPH vs SPYD | |
| State Street Energy Select Sector SPDR ETF | Energy Equities | 75 | 33.31% | 38.64B | Dec 1998 | XPH vs XLE | |
| SPDR Gold MiniShares Trust | Gold, Precious Metals | 28 | -6.13% | 27.37B | Jun 2018 | XPH vs GLDM | |
| State Street Utilities Select Sector SPDR ETF | Utilities Equities | 21 | 5.31% | 23.07B | Dec 1998 | XPH vs XLU | |
| SPDR Bloomberg 1-3 Month T-Bill ETF | Government Bonds, Ultrashort Bond | 100 | 2.10% | 47.03B | May 2007 | XPH vs BIL |
Often Compared With XPH
Investors most often compare XPH with PPH, ALC, IBB. These 20 comparison targets span 3 categories, based on PortfoliosLab usage data.
Compare XPH with Any Fund or Stock
Compare XPH with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair XPH with funds that move differently
SPDR S&P Pharmaceuticals ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to XPH.
Explore XPH Diversifiers