XPH vs. JAGLX

Last updated Jul 17, 2026

XPH (SPDR S&P Pharmaceuticals ETF) and JAGLX (Janus Henderson Global Life Sciences Fund Class T) are both Health & Biotech Equities funds. XPH is passively managed, while JAGLX is actively managed. Over the past 10 years, XPH returned 5.30%/yr vs 11.99%/yr for JAGLX. Their correlation of 0.82 suggests significant overlap in exposure. XPH charges 0.35%/yr vs 0.92%/yr for JAGLX.

Performance

XPH vs. JAGLX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in SPDR S&P Pharmaceuticals ETF (XPH) and Janus Henderson Global Life Sciences Fund Class T (JAGLX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, XPH achieves a 20.41% return, which is significantly higher than JAGLX's 7.88% return. Over the past 10 years, XPH has underperformed JAGLX with an annualized return of 5.30%, while JAGLX has yielded a comparatively higher 11.99% annualized return.

XPH

• 1D: -0.97%
• 1M: 11.87%
• 6M: 20.37%
• YTD: 20.41%
• 1Y: 60.23%
• 3Y*: 19.29%
• 5Y*: 7.76%
• 10Y*: 5.30%

JAGLX

• 1D: 0.20%
• 1M: 6.60%
• 6M: 5.98%
• YTD: 7.88%
• 1Y: 36.74%
• 3Y*: 15.18%
• 5Y*: 9.45%
• 10Y*: 11.99%

*Multi-year figures are annualized to reflect compound growth (CAGR)

XPH vs. JAGLX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
XPH SPDR S&P Pharmaceuticals ETF	20.41%	31.60%	4.94%	2.97%	-9.83%	-10.54%	14.68%	25.61%	-15.32%	12.05%
JAGLX Janus Henderson Global Life Sciences Fund Class T	7.88%	24.72%	8.50%	7.41%	-2.79%	6.66%	25.52%	29.12%	4.05%	22.13%

Correlation

The correlation between XPH and JAGLX is 0.74, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.74
Correlation (3Y) Calculated over the trailing 3-year period	0.75
Correlation (5Y) Calculated over the trailing 5-year period	0.79
Correlation (10Y) Calculated over the trailing 10-year period	0.80
Correlation (All Time) Calculated using the full available price history since Jun 22, 2006	0.82

The correlation between XPH and JAGLX has been stable across timeframes, ranging from 0.74 to 0.82 - a consistent structural relationship.

Return for Risk

XPH vs. JAGLX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XPH

XPH Risk / Return Rank: 92
XPH Sharpe Ratio Rank: 93
XPH Sortino Ratio Rank: 92
XPH Omega Ratio Rank: 88
XPH Calmar Ratio Rank: 93
XPH Martin Ratio Rank: 92

JAGLX

JAGLX Risk / Return Rank: 87
JAGLX Sharpe Ratio Rank: 89
JAGLX Sortino Ratio Rank: 87
JAGLX Omega Ratio Rank: 81
JAGLX Calmar Ratio Rank: 92
JAGLX Martin Ratio Rank: 86

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XPH vs. JAGLX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for SPDR S&P Pharmaceuticals ETF (XPH) and Janus Henderson Global Life Sciences Fund Class T (JAGLX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	XPH	JAGLX	Difference
Sharpe ratio: Return per unit of total volatility	2.71	2.45	+0.26
Sortino ratio: Return per unit of downside risk	3.61	3.57	+0.05
Omega ratio: Gain probability vs. loss probability	1.43	1.42	+0.01
Calmar ratio: Return relative to maximum drawdown	5.06	3.98	+1.07
Martin ratio: Return relative to average drawdown	17.97	12.58	+5.39

XPH vs. JAGLX - Sharpe Ratio Comparison

The current XPH Sharpe Ratio is 2.71, which is comparable to the JAGLX Sharpe Ratio of 2.45. The chart below compares the historical Sharpe Ratios of XPH and JAGLX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

XPH vs. JAGLX - Drawdown Comparison

The maximum XPH drawdown since its inception was -48.03%, smaller than the maximum JAGLX drawdown of -58.96%. Use the drawdown chart below to compare losses from any high point for XPH and JAGLX.

Drawdown Indicators

	XPH	JAGLX	Difference
Max Drawdown Largest peak-to-trough decline	-48.03%	-58.96%	+10.93%
Max Drawdown (1Y) Largest decline over 1 year	-11.97%	-9.71%	-2.26%
Max Drawdown (3Y) Largest decline over 3 years	-23.57%	-17.41%	-6.16%
Max Drawdown (5Y) Largest decline over 5 years	-31.63%	-22.25%	-9.38%
Max Drawdown (10Y) Largest decline over 10 years	-35.97%	-27.38%	-8.59%
Current Drawdown Current decline from peak	-3.93%	-3.92%	-0.01%
Average Drawdown Average peak-to-trough decline	-17.16%	-17.36%	+0.20%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.36%	3.07%	+0.29%

Volatility

XPH vs. JAGLX - Volatility Comparison

SPDR S&P Pharmaceuticals ETF (XPH) has a higher volatility of 7.19% compared to Janus Henderson Global Life Sciences Fund Class T (JAGLX) at 5.70%. This indicates that XPH's price experiences larger fluctuations and is considered to be riskier than JAGLX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XPH	JAGLX	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.19%	5.70%	+1.49%
Volatility (6M) Calculated over the trailing 6-month period	17.41%	12.17%	+5.24%
Volatility (1Y) Calculated over the trailing 1-year period	22.35%	15.86%	+6.49%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	21.07%	16.15%	+4.92%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	22.10%	17.39%	+4.71%

XPH vs. JAGLX - Expense Ratio Comparison

XPH has a 0.35% expense ratio, which is lower than JAGLX's 0.92% expense ratio.

Dividends

XPH vs. JAGLX - Dividend Comparison

XPH's dividend yield for the trailing twelve months is around 0.50%, less than JAGLX's 4.20% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JAGLX Janus Henderson Global Life Sciences Fund Class T	4.20%	4.53%	10.98%	4.22%	0.14%	9.78%	7.75%	6.17%	13.38%	0.89%	1.13%	9.09%
XPH SPDR S&P Pharmaceuticals ETF	0.50%	0.83%	1.58%	1.28%	1.64%	0.95%	0.47%	0.64%	0.65%	0.67%	0.63%	7.15%

Frequently Asked Questions

Can I hold both XPH and JAGLX in my portfolio?

XPH and JAGLX have a correlation of 0.74, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, XPH or JAGLX?

XPH has higher volatility (7.19%) compared to JAGLX (5.70%). In terms of maximum drawdown, XPH dropped -48.03% vs JAGLX's -58.96%.

Which has better risk-adjusted returns?

XPH currently has the higher Sharpe Ratio (2.71 vs 2.45), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.