- ISIN
- US00162Q5936
- CUSIP
- 00162Q593
- Issuer
- SS&C
- Inception Date
- Dec 31, 2014
- Region
- North America (U.S.)
- Category
- Health & Biotech Equities
- Leveraged
- 1x (No leverage)
- Index Tracked
- S-Network Medical Breakthroughs Index
- Distribution Policy
- Accumulating
- Asset Class
- Equity
- Asset Class Size
- Small-Cap
- Asset Class Style
- Growth
- Assets Under Management
- $160M
Share Price Chart
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Performance
SBIO Performance Chart
ALPS Medical Breakthroughs ETF (SBIO) is up 14.5% since the beginning of the year. SBIO is currently trading at $59 per share. Investors who bought $1,000 worth of SBIO shares 5 years ago would now be looking at an investment worth $1,247.
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Returns By Period
ALPS Medical Breakthroughs ETF (SBIO) has returned 14.53% so far this year and 95.53% over the past 12 months. Over the last ten years, SBIO has returned 11.14% per year, falling short of the S&P 500 Index benchmark, which averaged 13.88% annually.
ALPS Medical Breakthroughs ETF
- 1D
- 6.44%
- 1M
- 10.06%
- YTD
- 14.53%
- 6M
- 12.40%
- 1Y
- 95.53%
- 3Y*
- 23.70%
- 5Y*
- 4.51%
- 10Y*
- 11.14%
Benchmark (S&P 500 Index)
- 1D
- -0.37%
- 1M
- -0.01%
- YTD
- 9.16%
- 6M
- 8.64%
- 1Y
- 25.22%
- 3Y*
- 19.78%
- 5Y*
- 11.99%
- 10Y*
- 13.88%
SBIO Monthly Returns History
Based on dividend-adjusted daily data since Dec 31, 2014, SBIO's average daily return is +0.06%, while the average monthly return is +1.03%. At this rate, an investment would double in approximately 5.6 years.
Historically, 56% of months were positive and 44% were negative. The best month was Dec 2023 with a return of +25.4%, while the worst month was Jan 2016 at -28.2%. The longest winning streak lasted 13 consecutive months, and the longest losing streak was 4 months.
On a daily basis, SBIO closed higher 53% of trading days. The best single day was Nov 9, 2016 with a return of +11.1%, while the worst single day was Mar 16, 2020 at -15.8%.
| Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | 0.06% | 0.59% | 1.52% | 2.43% | 1.55% | 7.75% | 14.53% | ||||||
| 2025 | -0.04% | -5.13% | -8.94% | 4.04% | -1.81% | 3.22% | 8.59% | 6.65% | 11.58% | 16.15% | 10.58% | 2.62% | 55.07% |
| 2024 | 0.75% | 11.64% | -3.51% | -8.28% | 2.65% | -0.23% | 11.52% | -0.10% | -0.22% | 1.13% | 2.94% | -12.00% | 3.81% |
| 2023 | 7.24% | -7.04% | -10.24% | 10.25% | 5.47% | -0.19% | 1.44% | -7.07% | -8.47% | -9.81% | 7.25% | 25.40% | 8.68% |
| 2022 | -17.59% | -3.45% | 0.09% | -15.34% | -9.83% | 7.83% | 7.76% | 6.11% | -4.84% | 1.96% | 1.73% | -2.78% | -28.08% |
| 2021 | 9.38% | -1.54% | -8.88% | -0.30% | -7.00% | 4.96% | -10.02% | 6.59% | -3.01% | 1.23% | -6.88% | -1.54% | -17.55% |
Benchmark Metrics
ALPS Medical Breakthroughs ETF has an annualized alpha of -0.65%, beta of 1.15, and R2 of 0.36 versus S&P 500 Index. Calculated based on daily prices since December 31, 2014.
- This ETF participated in 122.14% of S&P 500 Index downside but only 107.33% of its upside - more exposed to losses than it benefited from rallies.
- R2 of 0.36 means the benchmark explains less than half of this ETF's behavior - treat beta with caution or consider switching to a more representative benchmark.
- Alpha
- -0.65%
- Beta
- 1.15
- R²
- 0.36
- Upside Capture
- 107.33%
- Downside Capture
- 122.14%
Expense Ratio
SBIO has an expense ratio of 0.50%, placing it in the medium range.
Return for Risk
Risk / Return Rank
SBIO ranks 91 for risk / return — in the top 91% of ETFs on our site. This means strong returns relative to risk — exactly what professional investors look for. Well-suited for investors who want to maximize return per unit of risk.
Return / Risk — by metrics
The table below present risk-adjusted performance metrics for ALPS Medical Breakthroughs ETF (SBIO) and compare them to S&P 500 Index.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| SBIO | Benchmark | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +1.13 | ||
| Sortino ratioReturn per unit of downside risk | +1.28 | ||
| Omega ratioGain probability vs. loss probability | 1.48 | 1.37 | +0.11 |
| Calmar ratioReturn relative to maximum drawdown | 7.59 | 2.78 | +4.81 |
| Martin ratioReturn relative to average drawdown | 21.16 | 12.44 | +8.72 |
Dividends
Dividend History
ALPS Medical Breakthroughs ETF provided a 0.00% dividend yield over the last twelve months, with an annual payout of $0.00 per share.
| Period | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Dividend | $0.00 | $0.00 | $1.17 | $0.07 | $0.00 | $0.00 | $0.00 | $0.02 | $0.78 | $0.58 |
Dividend yield | 0.00% | 0.00% | 3.55% | 0.22% | 0.00% | 0.00% | 0.00% | 0.04% | 2.79% | 1.77% |
Monthly Dividends
The table displays the monthly dividend distributions for ALPS Medical Breakthroughs ETF. The dividends shown in the table have been adjusted to account for any splits that may have occurred.
| Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | ||||||
| 2025 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 |
| 2024 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $1.17 | $1.17 |
| 2023 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.07 | $0.07 |
| 2022 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 |
| 2021 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | $0.00 |
Drawdowns
Drawdowns Chart
The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.
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Worst Drawdowns
The table below displays the maximum drawdowns of the ALPS Medical Breakthroughs ETF. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.
The maximum drawdown for the ALPS Medical Breakthroughs ETF was 63.06%, occurring on Oct 27, 2023. The portfolio has not yet recovered.
The current ALPS Medical Breakthroughs ETF drawdown is 4.33%.
Related event | Drawdown | Fall | Recovery | Underwater |
|---|---|---|---|---|
2023 bear market2023 | -63.06%Oct 2023 | 2y 8mo | — | 5y 4moFeb 2021 - now |
2016 bear market2016 | -49.69%Nov 2016 | 1y 3mo | 1y 7mo | 2y 10moJul 2015 - Jun 2018 |
COVID crash2020 | -39.30%Mar 2020 | 2mo 21d | 3mo 9d | 6moDec 2019 - Jun 2020 |
Rate-hike selloffLate 2018 | -32.50%Dec 2018 | 2mo 24d | 11mo 6d | 1y 1moOct 2018 - Nov 2019 |
2015 correction2015 | -13.78%Apr 2015 | 6d | 20d | 26dApr 2015 - May 2015 |
Drawdown Indicators
| SBIO | Benchmark | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -63.06% | -56.78% | -6.28% |
Max Drawdown (1Y)Largest decline over 1 year | -12.66% | -9.10% | -3.56% |
Max Drawdown (3Y)Largest decline over 3 years | -42.44% | -18.90% | -23.54% |
Max Drawdown (5Y)Largest decline over 5 years | -53.10% | -25.43% | -27.67% |
Max Drawdown (10Y)Largest decline over 10 years | -63.06% | -33.92% | -29.14% |
Current DrawdownCurrent decline from peak | -4.33% | -1.80% | -2.53% |
Average DrawdownAverage peak-to-trough decline | -28.37% | -10.71% | -17.66% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 4.53% | 2.03% | +2.50% |
Volatility
Volatility Chart
The chart below shows the rolling one-month volatility.
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