SPDR S&P Biotech ETF (XBI) Alternatives
SPDR S&P Biotech ETF (XBI) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with XBI. Use the tables to find lower-cost options, better risk-adjusted returns, or funds that fit a different role in your portfolio.
Cheapest Alternatives to XBI
XBI charges 0.35% annually. Among ETFs in the Health & Biotech Equities category, these options have the lowest expense ratios among XBI alternatives.
| Symbol | Name | Expense Ratio | Inception | |
|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | Oct 21, 2013 | XBI vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | Dec 16, 1998 | XBI vs XLV | |
| Vanguard Health Care ETF | 0.10% | Jan 26, 2004 | XBI vs VHT | |
| Invesco S&P SmallCap Health Care ETF | 0.29% | Apr 7, 2010 | XBI vs PSCH | |
| SPDR S&P Pharmaceuticals ETF | 0.35% | Jun 19, 2006 | XBI vs XPH |
Best Risk-Adjusted Alternatives to XBI
Among ETFs in the Health & Biotech Equities category, these options rank highest on PortfoliosLab's risk-adjusted score, which accounts for volatility, drawdown, and return consistency over a 1-year period.
| Symbol | Name | Risk / Return Rank | Inception | |
|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 97 | Dec 16, 2014 | XBI vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | Dec 31, 2014 | XBI vs SBIO | |
| Tema Oncology ETF | 90 | Aug 14, 2023 | XBI vs CANC | |
| F/m Emerald Life Sciences Innovation ETF | 86 | Oct 30, 2024 | XBI vs LFSC | |
| Invesco Nasdaq Biotechnology ETF | 86 | Jun 11, 2021 | XBI vs IBBQ |
Top Performing XBI Alternatives (YTD)
XBI alternatives from the Health & Biotech Equities category, sorted by year-to-date return.
| Symbol | Name | YTD Return | Inception | |
|---|---|---|---|---|
| iShares Genomics Immunology and Healthcare ETF Gen... | 10.92% | Jun 11, 2019 | XBI vs IDNA | |
| Virtus LifeSci Biotech Clinical Trials ETF | 7.95% | Dec 16, 2014 | XBI vs BBC | |
| Tema Oncology ETF | 5.69% | Aug 14, 2023 | XBI vs CANC | |
| First Trust Nasdaq Pharmaceuticals ETF | 4.48% | Sep 20, 2016 | XBI vs FTXH | |
| Virtus LifeSci Biotech Products ETF | 3.94% | Dec 17, 2014 | XBI vs BBP |
Lowest Volatility Alternatives to XBI
XBI alternatives from the Health & Biotech Equities category, sorted by annualized volatility over the past year.
| Symbol | Name | Volatility 1Y | Inception | |
|---|---|---|---|---|
| Principal Healthcare Innovators Index ETF | 0.00% | Aug 19, 2016 | XBI vs BTEC | |
| Loncar Cancer Immunotherapy ETF | 0.00% | Oct 13, 2015 | XBI vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | Jun 17, 2020 | XBI vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.60% | Jun 29, 2007 | XBI vs SPAQ | |
| Global X Aging Population ETF | 15.94% | May 9, 2016 | XBI vs AGNG |
Lowest Drawdown Alternatives to XBI
XBI alternatives from the Health & Biotech Equities category, sorted by maximum drawdown over the past year.
| Symbol | Name | Max Drawdown 1Y | Inception | |
|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | Jun 17, 2020 | XBI vs GERM | |
| Horizon Kinetics SPAC Active ETF | -5.30% | Jun 29, 2007 | XBI vs SPAQ | |
| Jpmorgan Healthcare Leaders ETF | -9.68% | Nov 1, 2023 | XBI vs JDOC | |
| VanEck Vectors Pharmaceutical ETF | -10.02% | Dec 20, 2011 | XBI vs PPH | |
| Global X Aging Population ETF | -10.16% | May 9, 2016 | XBI vs AGNG |
Other ETFs from State Street
Most popular State Street ETFs on PortfoliosLab, across asset classes.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | Inception | |
|---|---|---|---|---|---|---|
| State Street SPDR S&P 500 ETF | S&P 500 | 64 | -4.37% | Jan 22, 1993 | XBI vs SPY | |
| SPDR Gold Shares | Gold, Precious Metals | 87 | 8.57% | Nov 18, 2004 | XBI vs GLD | |
| State Street Technology Select Sector SPDR ETF | Technology Equities | 69 | -7.57% | Dec 16, 1998 | XBI vs XLK | |
| State Street SPDR Portfolio S&P 500 Growth ETF | S&P 500, Large Cap Growth Equities | 66 | -8.12% | Sep 25, 2000 | XBI vs SPYG | |
| SPDR Portfolio S&P 500 High Dividend ETF | S&P 500, Dividend | 30 | 6.32% | Oct 21, 2015 | XBI vs SPYD | |
| SPDR Gold MiniShares Trust | Precious Metals, Gold | 88 | 8.57% | Jun 25, 2018 | XBI vs GLDM | |
| State Street Energy Select Sector SPDR ETF | Energy Equities | 73 | 37.91% | Dec 16, 1998 | XBI vs XLE | |
| Utilities Select Sector SPDR Fund | Utilities Equities | 71 | 8.25% | Dec 16, 1998 | XBI vs XLU | |
| SPDR Barclays 1-3 Month T-Bill ETF | Government Bonds | 100 | 0.85% | May 25, 2007 | XBI vs BIL | |
| SPDR Dow Jones Industrial Average ETF | Large Cap Growth Equities | 47 | -3.25% | Jan 14, 1998 | XBI vs DIA |
Often Compared With XBI
What investors most often compare with XBI, based on PortfoliosLab usage data.
Compare XBI with Any Fund or Stock
Compare XBI with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.