XBI vs. CNCR

Last updated Jun 5, 2026

XBI (SPDR S&P Biotech ETF) and CNCR (Loncar Cancer Immunotherapy ETF) are both Health & Biotech Equities funds - XBI tracks the S&P Biotechnology Select Industry Index while CNCR tracks the Loncar Cancer Immunotherapy Index. Both are passively managed. XBI charges 0.35%/yr vs 0.79%/yr for CNCR.

Performance

XBI vs. CNCR - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in SPDR S&P Biotech ETF (XBI) and Loncar Cancer Immunotherapy ETF (CNCR). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

XBI

• 1D: 2.77%
• 1M: -0.28%
• YTD: 9.42%
• 6M: 8.61%
• 1Y: 62.35%
• 3Y*: 15.65%
• 5Y*: 1.14%
• 10Y*: 8.53%

CNCR

• 1D: 0.00%
• 1M: 0.00%
• YTD: —
• 6M: —
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

XBI vs. CNCR - Yearly Performance Comparison

	2026 (YTD)
XBI SPDR S&P Biotech ETF	6.30%
CNCR Loncar Cancer Immunotherapy ETF	0.00%

XBI vs. CNCR - Sectors Allocation Comparison

Sectors	XBI	CNCR
Healthcare	99.8%	96.6%
Financial Services	0.2%	3.3%
Basic Materials	0.2%	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

XBI vs. CNCR — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XBI

XBI Risk / Return Rank: 80
XBI Sharpe Ratio Rank: 77
XBI Sortino Ratio Rank: 75
XBI Omega Ratio Rank: 67
XBI Calmar Ratio Rank: 93
XBI Martin Ratio Rank: 89

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XBI vs. CNCR - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for SPDR S&P Biotech ETF (XBI) and Loncar Cancer Immunotherapy ETF (CNCR). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	XBI	CNCR	Difference
Sharpe ratio: Return per unit of total volatility	2.45	—	—
Sortino ratio: Return per unit of downside risk	3.32	—	—
Omega ratio: Gain probability vs. loss probability	1.40	—	—
Calmar ratio: Return relative to maximum drawdown	6.45	—	—
Martin ratio: Return relative to average drawdown	19.53	—	—
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

Sharpe Ratios by Period

	XBI	CNCR	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.45	—	—
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.04	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.27	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.36	—	—

Drawdowns

XBI vs. CNCR - Drawdown Comparison

The maximum XBI drawdown since its inception was -63.89%, which is greater than CNCR's maximum drawdown of 0.00%. Use the drawdown chart below to compare losses from any high point for XBI and CNCR.

Drawdown Indicators

	XBI	CNCR	Difference
Max Drawdown Largest peak-to-trough decline	-63.89%	0.00%	-63.89%
Max Drawdown (1Y) Largest decline over 1 year	-9.72%	—	—
Max Drawdown (3Y) Largest decline over 3 years	-32.99%	—	—
Max Drawdown (5Y) Largest decline over 5 years	-54.71%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-63.89%	—	—
Current Drawdown Current decline from peak	-22.89%	0.00%	-22.89%
Average Drawdown Average peak-to-trough decline	-20.93%	0.00%	-20.93%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.20%	—	—

Volatility

Volatility by Period

	XBI	CNCR	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.69%	—	—
Volatility (6M) Calculated over the trailing 6-month period	20.31%	—	—
Volatility (1Y) Calculated over the trailing 1-year period	25.60%	0.00%	+25.60%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	32.20%	0.00%	+32.20%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.00%	0.00%	+32.00%

XBI vs. CNCR - Expense Ratio Comparison

XBI has a 0.35% expense ratio, which is lower than CNCR's 0.79% expense ratio.

Dividends

XBI vs. CNCR - Dividend Comparison

XBI's dividend yield for the trailing twelve months is around 0.33%, while CNCR has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
CNCR Loncar Cancer Immunotherapy ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
XBI SPDR S&P Biotech ETF	0.33%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%

Frequently Asked Questions

Which ETF is better, XBI or CNCR?

On fees, XBI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, XBI or CNCR?

XBI is cheaper with a 0.35% expense ratio, compared with 0.79% for CNCR.

Which ETF pays a higher dividend yield, XBI or CNCR?

XBI has the higher dividend yield at 0.33%, compared with 0.00% for CNCR.

What is the main difference between XBI and CNCR?

XBI tracks S&P Biotechnology Select Industry Index, while CNCR tracks Loncar Cancer Immunotherapy Index. They also come from different issuers: State Street and Exchange Traded Concepts. Their fees differ too: 0.35% for XBI and 0.79% for CNCR.