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NASDAQ Biotechnology Index (^NBI)
Performance
Risk-Adjusted Performance
Drawdowns
Volatility

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^NBI vs. ^IXIC
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Performance

Performance Chart

The chart shows the growth of an initial investment of $10,000 in NASDAQ Biotechnology Index, comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.


1,000.00%1,500.00%2,000.00%December2025FebruaryMarchAprilMay
1,877.36%
1,100.44%
^NBI (NASDAQ Biotechnology Index)
Benchmark (^GSPC)

Returns By Period

NASDAQ Biotechnology Index (^NBI) returned -7.34% year-to-date (YTD) and -8.79% over the past 12 months. Over the past 10 years, ^NBI returned 0.81% annually, underperforming the S&P 500 benchmark at 10.31%.


^NBI

YTD

-7.34%

1M

3.57%

6M

-16.97%

1Y

-8.79%

5Y*

-0.20%

10Y*

0.81%

^GSPC (Benchmark)

YTD

-4.26%

1M

11.24%

6M

-5.02%

1Y

8.55%

5Y*

14.02%

10Y*

10.31%

*Annualized

Monthly Returns

The table below presents the monthly returns of ^NBI, with color gradation from worst to best to easily spot seasonal factors. Returns are adjusted for dividends.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
20255.15%-0.32%-6.06%0.38%-6.25%-7.34%
20240.33%0.99%0.03%-6.04%5.74%3.28%6.56%0.79%-2.34%-2.47%-0.11%-7.19%-1.37%
20233.50%-6.55%1.23%1.50%-2.73%0.10%1.30%-0.37%-3.91%-6.56%4.87%12.82%3.74%
2022-12.63%-4.12%4.25%-9.73%-1.32%1.02%4.11%-1.06%-2.44%8.91%5.87%-3.01%-11.68%
20216.25%-2.37%-4.29%2.97%-2.03%8.00%-0.20%4.09%-4.91%-1.89%-3.95%-0.45%0.23%
2020-5.60%0.30%-5.38%14.97%8.45%1.61%-1.70%0.90%-0.13%-3.73%11.14%4.49%25.69%
201913.40%2.67%-0.88%-4.82%-6.10%9.20%-3.08%-2.64%-3.30%7.73%11.44%0.84%24.41%
20186.96%-5.36%-1.28%-2.97%4.69%1.35%6.17%4.81%-0.19%-14.60%4.69%-11.25%-9.32%
20174.96%6.79%-1.23%1.48%-3.95%8.49%2.90%4.53%0.06%-5.81%0.54%1.47%21.06%
2016-21.01%-4.87%2.51%2.87%4.22%-7.88%12.43%-2.98%3.02%-11.38%6.78%-3.21%-21.68%
20155.90%4.90%1.91%-2.75%9.24%1.13%3.58%-10.58%-11.46%7.61%2.57%1.21%11.42%
20148.41%7.63%-10.70%-2.69%4.21%7.30%-2.34%10.26%-1.16%8.52%2.48%-0.07%34.10%

Risk-Adjusted Performance

Risk-Adjusted Performance Rank

The current rank of ^NBI is 11, meaning it’s performing worse than 89% of other indices on our website when it comes to balancing risk and reward. Below is a breakdown of how it compares using common performance measures.


The Risk-Adjusted Performance Rank of ^NBI is 1111
Overall Rank
The Sharpe Ratio Rank of ^NBI is 1111
Sharpe Ratio Rank
The Sortino Ratio Rank of ^NBI is 1212
Sortino Ratio Rank
The Omega Ratio Rank of ^NBI is 1212
Omega Ratio Rank
The Calmar Ratio Rank of ^NBI is 1212
Calmar Ratio Rank
The Martin Ratio Rank of ^NBI is 77
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

Risk-Adjusted Performance Indicators

The charts below present risk-adjusted performance metrics for NASDAQ Biotechnology Index (^NBI) and compare them to a chosen benchmark (^GSPC). These indicators evaluate an investment's returns against its associated risks.


The current NASDAQ Biotechnology Index Sharpe ratio is -0.41. This value is calculated based on the past 1 year of trading data and takes into account price changes and dividends.

Use the chart below to compare the Sharpe ratio of NASDAQ Biotechnology Index with the selected benchmark, providing insights into the investment's historical performance in terms of risk-adjusted returns. Go to the Sharpe ratio tool for more fine-grained control over the calculation options.


Rolling 12-month Sharpe Ratio-1.000.001.002.003.00December2025FebruaryMarchAprilMay
-0.41
0.44
^NBI (NASDAQ Biotechnology Index)
Benchmark (^GSPC)

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


-35.00%-30.00%-25.00%-20.00%-15.00%-10.00%-5.00%0.00%December2025FebruaryMarchAprilMay
-27.07%
-8.35%
^NBI (NASDAQ Biotechnology Index)
Benchmark (^GSPC)

Worst Drawdowns

The table below displays the maximum drawdowns of the NASDAQ Biotechnology Index. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the NASDAQ Biotechnology Index was 74.70%, occurring on Jul 10, 2002. Recovery took 2681 trading sessions.

The current NASDAQ Biotechnology Index drawdown is 27.07%.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-74.7%Mar 7, 2000587Jul 10, 20022681Mar 5, 20133268
-39.4%Jul 21, 2015237Jun 27, 2016973May 11, 20201210
-38.5%Aug 10, 2021212Jun 13, 2022
-31.85%Feb 1, 199455Apr 20, 1994319Jul 26, 1995374
-28.07%Oct 14, 1997222Aug 31, 199846Nov 4, 1998268

Volatility

Volatility Chart

The current NASDAQ Biotechnology Index volatility is 12.14%, representing the average percentage change in the investments's value, either up or down over the past month. The chart below shows the rolling one-month volatility.


2.00%4.00%6.00%8.00%10.00%12.00%14.00%December2025FebruaryMarchAprilMay
12.14%
11.43%
^NBI (NASDAQ Biotechnology Index)
Benchmark (^GSPC)