XBI vs. SBIO

Last updated Jun 26, 2026

XBI (SPDR S&P Biotech ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both Health & Biotech Equities funds - XBI tracks the S&P Biotechnology Select Industry Index while SBIO tracks the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past 10 years, XBI returned 11.96%/yr vs 12.17%/yr for SBIO. With a 0.95 correlation, they move nearly in lockstep. XBI charges 0.35%/yr vs 0.50%/yr for SBIO.

Performance

XBI vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in SPDR S&P Biotech ETF (XBI) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, XBI achieves a 24.45% return, which is significantly higher than SBIO's 19.82% return. Both investments have delivered pretty close results over the past 10 years, with XBI having a 11.96% annualized return and SBIO not far ahead at 12.17%.

XBI

• 1D: 1.26%
• 1M: 13.79%
• YTD: 24.45%
• 6M: 20.14%
• 1Y: 82.88%
• 3Y*: 22.41%
• 5Y*: 1.92%
• 10Y*: 11.96%

SBIO

• 1D: 0.87%
• 1M: 14.60%
• YTD: 19.82%
• 6M: 16.01%
• 1Y: 101.12%
• 3Y*: 26.56%
• 5Y*: 4.91%
• 10Y*: 12.17%

*Multi-year figures are annualized to reflect compound growth (CAGR)

XBI vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
XBI SPDR S&P Biotech ETF	24.45%	35.89%	1.01%	7.60%	-25.87%	-20.45%	48.33%	32.56%	-15.28%	43.77%
SBIO ALPS Medical Breakthroughs ETF	19.82%	55.07%	3.81%	8.68%	-28.08%	-17.55%	21.17%	50.30%	-11.81%	45.67%

Correlation

The correlation between XBI and SBIO is 0.95, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.95
Correlation (3Y) Calculated over the trailing 3-year period	0.93
Correlation (5Y) Calculated over the trailing 5-year period	0.95
Correlation (10Y) Calculated over the trailing 10-year period	0.95
Correlation (All Time) Calculated using the full available price history since Dec 31, 2014	0.95

The correlation between XBI and SBIO has been stable across timeframes, ranging from 0.93 to 0.95 - a consistent structural relationship.

XBI vs. SBIO - Sectors Allocation Comparison

Sectors	XBI	SBIO
Healthcare	99.7%	100.0%
Financial Services	0.3%	-0.0%
Basic Materials	0.2%	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

XBI vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XBI

XBI Risk / Return Rank: 94
XBI Sharpe Ratio Rank: 95
XBI Sortino Ratio Rank: 93
XBI Omega Ratio Rank: 89
XBI Calmar Ratio Rank: 97
XBI Martin Ratio Rank: 95

SBIO

SBIO Risk / Return Rank: 94
SBIO Sharpe Ratio Rank: 95
SBIO Sortino Ratio Rank: 94
SBIO Omega Ratio Rank: 90
SBIO Calmar Ratio Rank: 96
SBIO Martin Ratio Rank: 94

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XBI vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for SPDR S&P Biotech ETF (XBI) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	XBI	SBIO	Difference
Sharpe ratio: Return per unit of total volatility	3.15	3.34	-0.19
Sortino ratio: Return per unit of downside risk	4.01	4.19	-0.19
Omega ratio: Gain probability vs. loss probability	1.48	1.50	-0.02
Calmar ratio: Return relative to maximum drawdown	8.57	8.03	+0.54
Martin ratio: Return relative to average drawdown	25.32	22.41	+2.92

XBI vs. SBIO - Sharpe Ratio Comparison

The current XBI Sharpe Ratio is 3.15, which is comparable to the SBIO Sharpe Ratio of 3.34. The chart below compares the historical Sharpe Ratios of XBI and SBIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

XBI vs. SBIO - Drawdown Comparison

The maximum XBI drawdown since its inception was -63.89%, roughly equal to the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for XBI and SBIO.

Drawdown Indicators

	XBI	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-63.89%	-63.06%	-0.83%
Max Drawdown (1Y) Largest decline over 1 year	-9.72%	-12.66%	+2.94%
Max Drawdown (3Y) Largest decline over 3 years	-32.99%	-42.44%	+9.45%
Max Drawdown (5Y) Largest decline over 5 years	-54.71%	-53.10%	-1.61%
Max Drawdown (10Y) Largest decline over 10 years	-63.89%	-63.06%	-0.83%
Current Drawdown Current decline from peak	-12.30%	0.00%	-12.30%
Average Drawdown Average peak-to-trough decline	-20.93%	-28.35%	+7.42%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.28%	4.53%	-1.25%

Volatility

XBI vs. SBIO - Volatility Comparison

The current volatility for SPDR S&P Biotech ETF (XBI) is 9.94%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 11.21%. This indicates that XBI experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XBI	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.94%	11.21%	-1.27%
Volatility (6M) Calculated over the trailing 6-month period	21.13%	23.69%	-2.56%
Volatility (1Y) Calculated over the trailing 1-year period	26.48%	30.43%	-3.95%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	32.30%	33.76%	-1.46%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.00%	33.19%	-1.19%

XBI vs. SBIO - Expense Ratio Comparison

XBI has a 0.35% expense ratio, which is lower than SBIO's 0.50% expense ratio.

Dividends

XBI vs. SBIO - Dividend Comparison

XBI's dividend yield for the trailing twelve months is around 0.38%, while SBIO has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%	0.00%	0.00%
XBI SPDR S&P Biotech ETF	0.38%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%

Frequently Asked Questions

Can I hold both XBI and SBIO in my portfolio?

With a correlation of 0.95, XBI and SBIO move almost identically. Holding both adds very little diversification - you're essentially doubling your position in the same market segment. Choosing one is usually more capital-efficient.

Which is riskier, XBI or SBIO?

SBIO has higher volatility (11.21%) compared to XBI (9.94%). In terms of maximum drawdown, XBI dropped -63.89% vs SBIO's -63.06%.

Which ETF is better, XBI or SBIO?

On 10-year performance, SBIO leads with 12.17% vs 11.96% for XBI. On fees, XBI is cheaper at 0.35% per year. On volatility, XBI has been the lower-risk option at 9.94%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, XBI or SBIO?

Over the 10-year period, SBIO has performed better with a 12.17% return vs 11.96%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, XBI or SBIO?

XBI is cheaper with a 0.35% expense ratio, compared with 0.50% for SBIO.

Which ETF pays a higher dividend yield, XBI or SBIO?

XBI has the higher dividend yield at 0.38%, compared with 0.00% for SBIO.

What is the main difference between XBI and SBIO?

XBI tracks S&P Biotechnology Select Industry Index, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: State Street and SS&C. Their fees differ too: 0.35% for XBI and 0.50% for SBIO.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (3.34 vs 3.15), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.