XBI vs. ETIHX

Last updated Jun 5, 2026

XBI (SPDR S&P Biotech ETF) and ETIHX (Eventide Healthcare & Life Sciences Fund) are both Health & Biotech Equities funds. Over the past 10 years, XBI returned 8.53%/yr vs 11.89%/yr for ETIHX. Their correlation of 0.92 suggests significant overlap in exposure. XBI charges 0.35%/yr vs 1.30%/yr for ETIHX.

Performance

XBI vs. ETIHX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in SPDR S&P Biotech ETF (XBI) and Eventide Healthcare & Life Sciences Fund (ETIHX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, XBI achieves a 9.42% return, which is significantly higher than ETIHX's -6.48% return. Over the past 10 years, XBI has underperformed ETIHX with an annualized return of 8.53%, while ETIHX has yielded a comparatively higher 11.89% annualized return.

XBI

• 1D: 2.77%
• 1M: -0.28%
• YTD: 9.42%
• 6M: 8.61%
• 1Y: 62.35%
• 3Y*: 15.65%
• 5Y*: 1.14%
• 10Y*: 8.53%

ETIHX

• 1D: 1.02%
• 1M: -7.57%
• YTD: -6.48%
• 6M: -7.55%
• 1Y: 48.58%
• 3Y*: 9.06%
• 5Y*: 3.34%
• 10Y*: 11.89%

*Multi-year figures are annualized to reflect compound growth (CAGR)

XBI vs. ETIHX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
XBI SPDR S&P Biotech ETF	9.42%	35.89%	1.01%	7.60%	-25.87%	-20.45%	48.33%	32.56%	-15.28%	43.77%
ETIHX Eventide Healthcare & Life Sciences Fund	-6.48%	56.73%	-10.13%	11.01%	-19.62%	-16.87%	37.12%	58.74%	-0.27%	45.83%

Correlation

The correlation between XBI and ETIHX is 0.88, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.88
Correlation (3Y) Calculated over the trailing 3-year period	0.91
Correlation (5Y) Calculated over the trailing 5-year period	0.92
Correlation (10Y) Calculated over the trailing 10-year period	0.91
Correlation (All Time) Calculated using the full available price history since Jan 3, 2013	0.92

The correlation between XBI and ETIHX has been stable across timeframes, ranging from 0.88 to 0.92 - a consistent structural relationship.

Return for Risk

XBI vs. ETIHX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XBI

XBI Risk / Return Rank: 80
XBI Sharpe Ratio Rank: 77
XBI Sortino Ratio Rank: 75
XBI Omega Ratio Rank: 67
XBI Calmar Ratio Rank: 93
XBI Martin Ratio Rank: 89

ETIHX

ETIHX Risk / Return Rank: 58
ETIHX Sharpe Ratio Rank: 50
ETIHX Sortino Ratio Rank: 45
ETIHX Omega Ratio Rank: 42
ETIHX Calmar Ratio Rank: 84
ETIHX Martin Ratio Rank: 68

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XBI vs. ETIHX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for SPDR S&P Biotech ETF (XBI) and Eventide Healthcare & Life Sciences Fund (ETIHX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	XBI	ETIHX	Difference
Sharpe ratio: Return per unit of total volatility	2.45	2.08	+0.37
Sortino ratio: Return per unit of downside risk	3.32	2.81	+0.51
Omega ratio: Gain probability vs. loss probability	1.40	1.35	+0.05
Calmar ratio: Return relative to maximum drawdown	6.45	3.94	+2.50
Martin ratio: Return relative to average drawdown	19.53	13.14	+6.40
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

XBI vs. ETIHX - Sharpe Ratio Comparison

The current XBI Sharpe Ratio is 2.45, which is comparable to the ETIHX Sharpe Ratio of 2.08. The chart below compares the historical Sharpe Ratios of XBI and ETIHX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	XBI	ETIHX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.45	2.08	+0.37
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.04	0.12	-0.08
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.27	0.42	-0.15
Sharpe Ratio (All Time) Calculated using the full available price history	0.36	0.51	-0.14

Drawdowns

XBI vs. ETIHX - Drawdown Comparison

The maximum XBI drawdown since its inception was -63.89%, which is greater than ETIHX's maximum drawdown of -55.11%. Use the drawdown chart below to compare losses from any high point for XBI and ETIHX.

Drawdown Indicators

	XBI	ETIHX	Difference
Max Drawdown Largest peak-to-trough decline	-63.89%	-55.11%	-8.78%
Max Drawdown (1Y) Largest decline over 1 year	-9.72%	-12.50%	+2.78%
Max Drawdown (3Y) Largest decline over 3 years	-32.99%	-33.23%	+0.24%
Max Drawdown (5Y) Largest decline over 5 years	-54.71%	-49.27%	-5.44%
Max Drawdown (10Y) Largest decline over 10 years	-63.89%	-55.11%	-8.78%
Current Drawdown Current decline from peak	-22.89%	-9.94%	-12.95%
Average Drawdown Average peak-to-trough decline	-20.93%	-17.98%	-2.95%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.20%	3.74%	-0.54%

Volatility

XBI vs. ETIHX - Volatility Comparison

SPDR S&P Biotech ETF (XBI) and Eventide Healthcare & Life Sciences Fund (ETIHX) have volatilities of 9.69% and 9.64%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XBI	ETIHX	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.69%	9.64%	+0.05%
Volatility (6M) Calculated over the trailing 6-month period	20.31%	18.82%	+1.49%
Volatility (1Y) Calculated over the trailing 1-year period	25.60%	23.73%	+1.87%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	32.20%	27.85%	+4.35%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.00%	28.40%	+3.60%

XBI vs. ETIHX - Expense Ratio Comparison

XBI has a 0.35% expense ratio, which is lower than ETIHX's 1.30% expense ratio.

Dividends

XBI vs. ETIHX - Dividend Comparison

XBI's dividend yield for the trailing twelve months is around 0.33%, while ETIHX has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
ETIHX Eventide Healthcare & Life Sciences Fund	0.00%	0.00%	0.00%	0.00%	0.00%	10.78%	3.49%	2.08%	7.33%	1.28%	0.00%	1.22%
XBI SPDR S&P Biotech ETF	0.33%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%

Frequently Asked Questions

Can I hold both XBI and ETIHX in my portfolio?

XBI and ETIHX have a correlation of 0.88, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, XBI or ETIHX?

XBI has higher volatility (9.69%) compared to ETIHX (9.64%). In terms of maximum drawdown, XBI dropped -63.89% vs ETIHX's -55.11%.

Which has better risk-adjusted returns?

XBI currently has the higher Sharpe Ratio (2.45 vs 2.08), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.