First Trust Nasdaq Pharmaceuticals ETF (FTXH) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with FTXH. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to FTXH
FTXH charges 0.60% annually. There are 40 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | FTXH vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 42.10B | Dec 1998 | FTXH vs XLV | |
| Vanguard Health Care ETF | 0.09% | 20.40B | Jan 2004 | FTXH vs VHT | |
| VanEck Healthcare TruSector ETF | 0.10% | 850.50K | Apr 2026 | FTXH vs TRUH | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 933.15M | Nov 2025 | FTXH vs PBPH |
Best Risk-Adjusted Alternatives to FTXH
FTXH has a PortfoliosLab risk / return rank of 95. There are 2 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 47.80M | Dec 2014 | FTXH vs BBC | |
| iShares U.S. Pharmaceuticals ETF | 95 | 1.65B | May 2006 | FTXH vs IHE | |
| ALPS Medical Breakthroughs ETF | 95 | 201.57M | Dec 2014 | FTXH vs SBIO | |
| Invesco Dynamic Pharmaceuticals ETF | 94 | 472.10M | Jun 2005 | FTXH vs PJP | |
| SPDR S&P Pharmaceuticals ETF | 94 | 502.65M | Jun 2006 | FTXH vs XPH |
Top Performing FTXH Alternatives (YTD)
FTXH is at 17.64% YTD. There are 16 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 36.76%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 36.76% | 1.73B | Oct 2014 | FTXH vs ARKG | |
| AdvisorShares Psychedelics ETF | 36.69% | 48.53M | Sep 2021 | FTXH vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 28.89% | 7.27M | Dec 2025 | FTXH vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 27.03% | 47.80M | Dec 2014 | FTXH vs BBC | |
| SPDR S&P Health Care Services ETF | 25.67% | 206.72M | Sep 2011 | FTXH vs XHS |
Lowest Volatility Alternatives to FTXH
FTXH has 17.04% 1-year volatility. There are 19 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | FTXH vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | FTXH vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.66% | 10.09M | Jun 2007 | FTXH vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.75% | 21.55M | Jul 2025 | FTXH vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 10.92% | 982.35K | Apr 2026 | FTXH vs MHIP |
Lowest Drawdown Alternatives to FTXH
FTXH has a 1-year max drawdown of -7.47%. There are 2 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | FTXH vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.20% | 10.09M | Jun 2007 | FTXH vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | -8.14% | 21.55M | Jul 2025 | FTXH vs XLVI | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 75.06M | Jun 2021 | FTXH vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.65B | May 2006 | FTXH vs IHE |
Other ETFs from First Trust
The 10 most viewed First Trust ETFs shown here include CIBR, GRID, AIRR and span 16 categories. AUM among these funds goes as high as $25B.
Often Compared With FTXH
Investors most often compare FTXH with PPH, BBP, MEDI. These 20 comparison targets span 6 categories, based on PortfoliosLab usage data.
Compare FTXH with Any Fund or Stock
Compare FTXH with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair FTXH with funds that move differently
First Trust Nasdaq Pharmaceuticals ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to FTXH.
Explore FTXH Diversifiers