FTXH vs. XLVI

Last updated Jul 15, 2026

FTXH (First Trust Nasdaq Pharmaceuticals ETF) and XLVI (State Street Health Care Select Sector SPDR Premium Income ETF) are both exchange-traded funds - FTXH is a Health & Biotech Equities fund tracking the Nasdaq U.S. Smart Pharmaceuticals Index, while XLVI is a Derivative Income fund actively managed by State Street. FTXH is passively managed, while XLVI is actively managed. Their correlation of 0.83 suggests significant overlap in exposure. FTXH charges 0.60%/yr vs 0.35%/yr for XLVI.

Performance

FTXH vs. XLVI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in First Trust Nasdaq Pharmaceuticals ETF (FTXH) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, FTXH achieves a 14.98% return, which is significantly higher than XLVI's 4.44% return.

FTXH

• 1D: -1.37%
• 1M: 4.98%
• 6M: 13.43%
• YTD: 14.98%
• 1Y: 43.98%
• 3Y*: 14.85%
• 5Y*: 9.49%
• 10Y*: —

XLVI

• 1D: -1.50%
• 1M: 2.12%
• 6M: 3.14%
• YTD: 4.44%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

FTXH vs. XLVI - Yearly Performance Comparison

	2026 (YTD)	2025
FTXH First Trust Nasdaq Pharmaceuticals ETF	14.98%	24.83%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	4.44%	12.41%

Correlation

The correlation between FTXH and XLVI is 0.83, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (All Time) Calculated using the full available price history since Jul 30, 2025	0.83

FTXH vs. XLVI - Sectors Allocation Comparison

Sectors	FTXH	XLVI
Healthcare	100.0%	100.0%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	101.4%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

FTXH vs. XLVI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

FTXH

FTXH Risk / Return Rank: 92
FTXH Sharpe Ratio Rank: 92
FTXH Sortino Ratio Rank: 93
FTXH Omega Ratio Rank: 87
FTXH Calmar Ratio Rank: 95
FTXH Martin Ratio Rank: 92

XLVI

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

FTXH vs. XLVI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for First Trust Nasdaq Pharmaceuticals ETF (FTXH) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	FTXH	XLVI	Difference
Sharpe ratio: Return per unit of total volatility	2.51	—	—
Sortino ratio: Return per unit of downside risk	3.72	—	—
Omega ratio: Gain probability vs. loss probability	1.42	—	—
Calmar ratio: Return relative to maximum drawdown	5.92	—	—
Martin ratio: Return relative to average drawdown	17.38	—	—

Drawdowns

FTXH vs. XLVI - Drawdown Comparison

The maximum FTXH drawdown since its inception was -32.11%, which is greater than XLVI's maximum drawdown of -8.14%. Use the drawdown chart below to compare losses from any high point for FTXH and XLVI.

Drawdown Indicators

	FTXH	XLVI	Difference
Max Drawdown Largest peak-to-trough decline	-32.11%	-8.14%	-23.97%
Max Drawdown (1Y) Largest decline over 1 year	-7.47%	—	—
Max Drawdown (3Y) Largest decline over 3 years	-19.51%	—	—
Max Drawdown (5Y) Largest decline over 5 years	-19.51%	—	—
Current Drawdown Current decline from peak	-4.40%	-1.52%	-2.88%
Average Drawdown Average peak-to-trough decline	-5.78%	-1.84%	-3.94%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.55%	—	—

Volatility

Volatility by Period

	FTXH	XLVI	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.70%	—	—
Volatility (6M) Calculated over the trailing 6-month period	12.56%	—	—
Volatility (1Y) Calculated over the trailing 1-year period	17.63%	10.96%	+6.67%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	16.51%	10.96%	+5.55%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	18.44%	10.96%	+7.48%

FTXH vs. XLVI - Expense Ratio Comparison

FTXH has a 0.60% expense ratio, which is higher than XLVI's 0.35% expense ratio.

Dividends

FTXH vs. XLVI - Dividend Comparison

FTXH's dividend yield for the trailing twelve months is around 1.12%, less than XLVI's 12.10% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016
FTXH First Trust Nasdaq Pharmaceuticals ETF	1.12%	1.41%	1.66%	1.55%	1.11%	1.03%	0.82%	0.67%	0.91%	2.18%	0.19%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	12.10%	5.73%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both FTXH and XLVI in my portfolio?

FTXH and XLVI have a correlation of 0.83, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, FTXH or XLVI?

On fees, XLVI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, FTXH or XLVI?

XLVI is cheaper with a 0.35% expense ratio, compared with 0.60% for FTXH.

Which ETF pays a higher dividend yield, FTXH or XLVI?

XLVI has the higher dividend yield at 12.10%, compared with 1.12% for FTXH.

What is the main difference between FTXH and XLVI?

FTXH is categorized as Health & Biotech Equities, while XLVI is Derivative Income. They also come from different issuers: First Trust and State Street. Their fees differ too: 0.60% for FTXH and 0.35% for XLVI.