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iShares Healthcare Innovation UCITS ETF (2B78.DE) Alternatives

ETF · Currency in EUR · Last updated Jun 5, 2026

2B78.DE is a passive ETF by iShares tracking the investment results of the iSTOXX® FactSet Breakthrough Healthcare. 2B78.DE launched on Sep 8, 2016 and has a 0.40% expense ratio.

iShares Healthcare Innovation UCITS ETF (2B78.DE) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with 2B78.DE. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.

Cheapest Alternatives to 2B78.DE

2B78.DE charges 0.40% annually. There are 19 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.12%.

SymbolNameExpense RatioAUMInception
XUHC.DE
Xtrackers MSCI USA Health Care UCITS ETF 1D0.12%—Sep 20172B78.DE vs XUHC.DE
QDVG.DE
iShares S&P 500 Health Care Sector UCITS ETF (Acc)0.15%—Nov 20152B78.DE vs QDVG.DE
ZPDH.DE
SPDR S&P US Health Care Select Sector UCITS ETF0.15%—Jul 20152B78.DE vs ZPDH.DE
DXSE.DE
Xtrackers MSCI Europe Health Care ESG Screened UCI...0.17%—Jun 20072B78.DE vs DXSE.DE
SPYH.DE
SPDR MSCI Europe Health Care UCITS ETF0.18%—Dec 20142B78.DE vs SPYH.DE

Best Risk-Adjusted Alternatives to 2B78.DE

2B78.DE has a PortfoliosLab risk / return rank of 26. There are 7 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 71.

SymbolNameRisk / Return RankAUMInception
2B70.DE
iShares Nasdaq US Biotechnology UCITS ETF
71
—Oct 20172B78.DE vs 2B70.DE
NBTK.DE
Invesco Nasdaq Biotech UCITS ETF
71
—Nov 20142B78.DE vs NBTK.DE
GN0M.DE
Global X Genomics & Biotechnology UCITS ETF
58
—Nov 20212B78.DE vs GN0M.DE
WRNA.DE
WisdomTree BioRevolution UCITS ETF USD Acc
56
—Dec 20212B78.DE vs WRNA.DE
2B77.DE
iShares Ageing Population UCITS ETF
43
—Sep 20162B78.DE vs 2B77.DE

Top Performing 2B78.DE Alternatives (YTD)

2B78.DE is at -2.07% YTD. There are 15 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 12.99%.

SymbolNameYTD ReturnAUMInception
GN0M.DE
Global X Genomics & Biotechnology UCITS ETF
12.99%
—Nov 20212B78.DE vs GN0M.DE
WRNA.DE
WisdomTree BioRevolution UCITS ETF USD Acc
10.48%
—Dec 20212B78.DE vs WRNA.DE
2B70.DE
iShares Nasdaq US Biotechnology UCITS ETF
4.53%
—Oct 20172B78.DE vs 2B70.DE
NBTK.DE
Invesco Nasdaq Biotech UCITS ETF
4.27%
—Nov 20142B78.DE vs NBTK.DE
2B77.DE
iShares Ageing Population UCITS ETF
2.83%
—Sep 20162B78.DE vs 2B77.DE

Lowest Volatility Alternatives to 2B78.DE

2B78.DE has 15.67% 1-year volatility. There are 11 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 12.28%.

SymbolNameVolatility 1YAUMInception
2B77.DE
iShares Ageing Population UCITS ETF12.28%—Sep 20162B78.DE vs 2B77.DE
XDWH.DE
Xtrackers MSCI World Health Care UCITS ETF 1C13.69%—Mar 20162B78.DE vs XDWH.DE
LYPE.DE
Amundi MSCI World Health Care UCITS ETF EUR Acc13.82%—Aug 20102B78.DE vs LYPE.DE
CBUF.DE
iShares MSCI World Health Care Sector ESG UCITS ET...13.98%—Oct 20192B78.DE vs CBUF.DE
XUHC.DE
Xtrackers MSCI USA Health Care UCITS ETF 1D14.51%—Sep 20172B78.DE vs XUHC.DE

Lowest Drawdown Alternatives to 2B78.DE

2B78.DE has a 1-year max drawdown of -12.05%. There are 10 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as -6.24%.

SymbolNameMax Drawdown 1YAUMInception
NBTK.DE
Invesco Nasdaq Biotech UCITS ETF
-6.24%
—Nov 20142B78.DE vs NBTK.DE
2B70.DE
iShares Nasdaq US Biotechnology UCITS ETF
-6.33%
—Oct 20172B78.DE vs 2B70.DE
2B77.DE
iShares Ageing Population UCITS ETF
-6.80%
—Sep 20162B78.DE vs 2B77.DE
ETLI.DE
L&G Pharma Breakthrough UCITS ETF
-9.06%
—Jan 20182B78.DE vs ETLI.DE
LYPE.DE
Amundi MSCI World Health Care UCITS ETF EUR Acc
-10.21%
—Aug 20102B78.DE vs LYPE.DE

Other ETFs from iShares

The 10 most viewed iShares ETFs shown here include SXR8.DE, QDVE.DE, SXRV.DE and span 8 categories.

SymbolNameCategoryRisk / Return RankYTD ReturnAUMInception
SXR8.DE
iShares Core S&P 500 UCITS ETF USD (Acc)S&P 500
69
11.37%
—May 20102B78.DE vs SXR8.DE
QDVE.DE
iShares S&P 500 Information Technology Sector UCIT...Technology Equities, S&P 500
65
24.06%
—Nov 20152B78.DE vs QDVE.DE
SXRV.DE
iShares NASDAQ 100 UCITS ETF USD (Acc)Nasdaq-100
71
20.57%
—Jan 20102B78.DE vs SXRV.DE
EUNL.DE
iShares Core MSCI World UCITS ETF USD (Acc)Global Equities
70
10.86%
—Sep 20092B78.DE vs EUNL.DE
IUSQ.DE
iShares MSCI ACWI UCITS ETF (Acc)Global Equities
76
12.65%
—Oct 20112B78.DE vs IUSQ.DE
SEC0.DE
iShares MSCI Global Semiconductors UCITS ETF USD (...Semiconductors, Technology Equities
97
98.10%
—Aug 20212B78.DE vs SEC0.DE
NQSE.DE
iShares NASDAQ 100 UCITS ETFNasdaq-100
66
17.82%
—Jan 20102B78.DE vs NQSE.DE
IS3N.DE
iShares Core MSCI Emerging Markets IMI UCITS ETF (...Emerging Markets Equities
82
25.82%
—May 20142B78.DE vs IS3N.DE
EUNA.DE
iShares Core Global Aggregate Bond UCITS ETF (EUR ...Global Bonds
14
-0.46%
—Nov 20172B78.DE vs EUNA.DE
ISPA.DE
iShares STOXX Global Select Dividend 100 UCITS ETF...Global Equities, Dividend
93
13.48%
—Sep 20092B78.DE vs ISPA.DE

Often Compared With 2B78.DE

Investors most often compare 2B78.DE with CBRS.DE, IS3R.DE, VFEA.DE. These 20 comparison targets span 9 categories, based on PortfoliosLab usage data.

SymbolNameCategoryRisk / Return RankYTD ReturnAUMInception
CBRS.DE
First Trust Nasdaq Cybersecurity UCITS ETF AccTechnology Equities
22
25.88%
—May 20202B78.DE vs CBRS.DE
IS3R.DE
iShares Edge MSCI World Momentum Factor UCITS ETF ...Momentum, Global Equities
62
22.51%
—Oct 20142B78.DE vs IS3R.DE
VFEA.DE
Vanguard FTSE Emerging Markets UCITS ETF AccEmerging Markets Equities
58
12.59%
—Sep 20192B78.DE vs VFEA.DE
QDV5.DE
iShares MSCI India UCITS ETF USD (Acc)Asia Pacific Equities
2
-11.72%
—May 20182B78.DE vs QDV5.DE
SPY
State Street SPDR S&P 500 ETFS&P 500
74
11.33%
781.00BJan 19932B78.DE vs SPY
^GSPC
S&P 500 Index
80
10.79%
——2B78.DE vs ^GSPC
VWCE.DE
Vanguard FTSE All-World UCITS ETFGlobal Equities
76
12.64%
—Jul 20192B78.DE vs VWCE.DE
XLV
State Street Health Care Select Sector SPDR ETFHealth & Biotech Equities
31
-1.35%
38.66BDec 19982B78.DE vs XLV
ESIH.DE
iShares MSCI Europe Health Care Sector UCITS ETF E...Health & Biotech Equities
15
-2.35%
—Nov 20202B78.DE vs ESIH.DE
EHLT.DE
Lyxor STOXX Europe 600 Healthcare UCITS ETF DistHealth & Biotech Equities
14
-2.49%
—Jul 20202B78.DE vs EHLT.DE
WELS.DE
Amundi S&P Global Health Care ESG UCITS ETF EUR Ac...Health & Biotech Equities
16
-3.35%
—Sep 20222B78.DE vs WELS.DE
WELG.DE
Amundi S&P Global Health Care ESG UCITS ETF EUR Di...Health & Biotech Equities
16
-3.60%
—Sep 20222B78.DE vs WELG.DE
LVMHF
LVMH Moët Hennessy - Louis Vuitton, Société Europé...
41
-26.32%
——2B78.DE vs LVMHF
SC0T.DE
Invesco European Health Care Sector UCITS ETFHealth & Biotech Equities
12
-3.57%
—Jul 20092B78.DE vs SC0T.DE
DDOC.DE
Global X Telemedicine & Digital Health UCITS ETF A...Health & Biotech Equities
9
-1.35%
—Dec 20202B78.DE vs DDOC.DE
LHTC.DE
Lyxor STOXX Europe 600 Healthcare UCITS ETF AccHealth & Biotech Equities
14
-2.55%
—Aug 20062B78.DE vs LHTC.DE
XDG3.DE
Xtrackers MSCI Global SDG 3 Good Health UCITS ETF ...Health & Biotech Equities
11
-6.02%
—Jan 20232B78.DE vs XDG3.DE
W311.DE
HANetf HAN-GINS Indxx Healthcare Megatrend Equal W...Health & Biotech Equities
18
-3.63%
—Apr 20192B78.DE vs W311.DE
EGLN.L
iShares Physical Gold ETCGold, Precious Metals
36
4.83%
31.65BApr 20112B78.DE vs EGLN.L
URTH
iShares MSCI World ETFGlobal Equities
67
10.71%
8.10BJan 20122B78.DE vs URTH

Compare 2B78.DE with Any Fund or Stock

Compare 2B78.DE with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.

 

Diversifiers

Pair 2B78.DE with funds that move differently

iShares Healthcare Innovation UCITS ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to 2B78.DE.

Explore 2B78.DE Diversifiers