2B78.DE vs. DXSE.DE
2B78.DE (iShares Healthcare Innovation UCITS ETF) and DXSE.DE (Xtrackers MSCI Europe Health Care ESG Screened UCITS ETF 1C) are both Health & Biotech Equities funds - 2B78.DE tracks the iSTOXX® FactSet Breakthrough Healthcare while DXSE.DE tracks the MSCI Europe Health Care ESG Screened 20-35. Both are passively managed. Over the past 5 years, 2B78.DE returned -1.74%/yr vs 5.38%/yr for DXSE.DE. A 0.60 correlation means they provide meaningful diversification when combined. 2B78.DE charges 0.40%/yr vs 0.17%/yr for DXSE.DE.
Performance
2B78.DE vs. DXSE.DE - Performance Comparison
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Returns By Period
In the year-to-date period, 2B78.DE achieves a -2.07% return, which is significantly lower than DXSE.DE's -1.95% return.
2B78.DE
- 1D
- 0.41%
- 1M
- 1.41%
- YTD
- -2.07%
- 6M
- -3.15%
- 1Y
- 14.42%
- 3Y*
- 2.27%
- 5Y*
- -1.74%
- 10Y*
- —
DXSE.DE
- 1D
- 2.90%
- 1M
- 0.52%
- YTD
- -1.95%
- 6M
- -0.32%
- 1Y
- 5.13%
- 3Y*
- 2.51%
- 5Y*
- 5.38%
- 10Y*
- 6.10%
2B78.DE vs. DXSE.DE - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
2B78.DE iShares Healthcare Innovation UCITS ETF | -2.07% | 5.50% | 7.24% | -0.29% | -19.03% | 1.15% | 38.75% | 16.74% | 0.39% | 19.45% |
DXSE.DE Xtrackers MSCI Europe Health Care ESG Screened UCITS ETF 1C | -1.95% | 4.97% | 4.52% | 9.56% | -5.75% | 25.75% | -1.94% | 32.90% | -1.01% | 4.42% |
Correlation
The correlation between 2B78.DE and DXSE.DE is 0.63, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.63 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.52 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.54 |
Correlation (All Time) Calculated using the full available price history since Sep 14, 2016 | 0.60 |
The correlation between 2B78.DE and DXSE.DE shifts across timeframes, from 0.52 (3 years) to 0.63 (1 year), reflecting how their relationship changes across market environments.
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Return for Risk
2B78.DE vs. DXSE.DE — Risk / Return Rank
2B78.DE
DXSE.DE
2B78.DE vs. DXSE.DE - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for iShares Healthcare Innovation UCITS ETF (2B78.DE) and Xtrackers MSCI Europe Health Care ESG Screened UCITS ETF 1C (DXSE.DE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| 2B78.DE | DXSE.DE | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.68 | ||
| Sortino ratioReturn per unit of downside risk | +0.91 | ||
| Omega ratioGain probability vs. loss probability | 1.17 | 1.06 | +0.11 |
| Calmar ratioReturn relative to maximum drawdown | 1.24 | 0.38 | +0.86 |
| Martin ratioReturn relative to average drawdown | 3.07 | 0.82 | +2.25 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| 2B78.DE | DXSE.DE | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 0.95 | 0.27 | +0.68 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.10 | 0.32 | -0.42 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | — | 0.38 | — |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.31 | 0.45 | -0.14 |
Drawdowns
2B78.DE vs. DXSE.DE - Drawdown Comparison
The maximum 2B78.DE drawdown since its inception was -38.58%, which is greater than DXSE.DE's maximum drawdown of -34.30%. Use the drawdown chart below to compare losses from any high point for 2B78.DE and DXSE.DE.
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Drawdown Indicators
| 2B78.DE | DXSE.DE | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -38.58% | -34.30% | -4.28% |
Max Drawdown (1Y)Largest decline over 1 year | -12.05% | -12.67% | +0.62% |
Max Drawdown (3Y)Largest decline over 3 years | -25.32% | -28.10% | +2.78% |
Max Drawdown (5Y)Largest decline over 5 years | -36.99% | -28.10% | -8.89% |
Max Drawdown (10Y)Largest decline over 10 years | — | -28.10% | — |
Current DrawdownCurrent decline from peak | -19.03% | -13.88% | -5.15% |
Average DrawdownAverage peak-to-trough decline | -14.36% | -8.34% | -6.02% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 4.86% | 5.81% | -0.95% |
Volatility
2B78.DE vs. DXSE.DE - Volatility Comparison
The current volatility for iShares Healthcare Innovation UCITS ETF (2B78.DE) is 3.74%, while Xtrackers MSCI Europe Health Care ESG Screened UCITS ETF 1C (DXSE.DE) has a volatility of 5.82%. This indicates that 2B78.DE experiences smaller price fluctuations and is considered to be less risky than DXSE.DE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| 2B78.DE | DXSE.DE | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 3.74% | 5.82% | -2.08% |
Volatility (6M)Calculated over the trailing 6-month period | 10.97% | 11.95% | -0.98% |
Volatility (1Y)Calculated over the trailing 1-year period | 15.67% | 17.63% | -1.96% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 17.91% | 16.48% | +1.43% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 18.79% | 16.04% | +2.75% |
2B78.DE vs. DXSE.DE - Expense Ratio Comparison
2B78.DE has a 0.40% expense ratio, which is higher than DXSE.DE's 0.17% expense ratio.
Dividends
2B78.DE vs. DXSE.DE - Dividend Comparison
Neither 2B78.DE nor DXSE.DE has paid dividends to shareholders.
Frequently Asked Questions
2B78.DE and DXSE.DE have a correlation of 0.63, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
On fees, DXSE.DE is cheaper at 0.17% per year. The better choice depends on whether you care most about return, fees, risk, or income.
DXSE.DE is cheaper with a 0.17% expense ratio, compared with 0.40% for 2B78.DE.
2B78.DE tracks iSTOXX® FactSet Breakthrough Healthcare, while DXSE.DE tracks MSCI Europe Health Care ESG Screened 20-35. They also come from different issuers: iShares and Xtrackers. Their fees differ too: 0.40% for 2B78.DE and 0.17% for DXSE.DE.
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