2B78.DE vs. NQSE.DE
2B78.DE (iShares Healthcare Innovation UCITS ETF) and NQSE.DE (iShares NASDAQ 100 UCITS ETF) are both exchange-traded funds - 2B78.DE is a Health & Biotech Equities fund tracking the iSTOXX® FactSet Breakthrough Healthcare, while NQSE.DE is a Nasdaq-100 fund tracking the NASDAQ-100 Index. Both are passively managed. Over the past 5 years, 2B78.DE returned -1.74%/yr vs 14.91%/yr for NQSE.DE. A 0.60 correlation means they provide meaningful diversification when combined. 2B78.DE charges 0.40%/yr vs 0.33%/yr for NQSE.DE.
Performance
2B78.DE vs. NQSE.DE - Performance Comparison
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Returns By Period
In the year-to-date period, 2B78.DE achieves a -2.07% return, which is significantly lower than NQSE.DE's 17.82% return.
2B78.DE
- 1D
- 0.41%
- 1M
- 1.41%
- YTD
- -2.07%
- 6M
- -3.15%
- 1Y
- 14.42%
- 3Y*
- 2.27%
- 5Y*
- -1.74%
- 10Y*
- —
NQSE.DE
- 1D
- -0.77%
- 1M
- 6.66%
- YTD
- 17.82%
- 6M
- 17.09%
- 1Y
- 35.67%
- 3Y*
- 25.27%
- 5Y*
- 14.91%
- 10Y*
- —
2B78.DE vs. NQSE.DE - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | |
|---|---|---|---|---|---|---|---|---|---|
2B78.DE iShares Healthcare Innovation UCITS ETF | -2.07% | 5.50% | 7.24% | -0.29% | -19.03% | 1.15% | 38.75% | 16.74% | -12.72% |
NQSE.DE iShares NASDAQ 100 UCITS ETF | 17.82% | 18.16% | 24.07% | 52.10% | -36.29% | 27.37% | 45.23% | 35.67% | -15.98% |
Correlation
The correlation between 2B78.DE and NQSE.DE is 0.39, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.39 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.45 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.57 |
Correlation (All Time) Calculated using the full available price history since Sep 11, 2018 | 0.60 |
Over the past year, the correlation between 2B78.DE and NQSE.DE has dropped to 0.39 - well below their long-term average of 0.60, suggesting their price drivers have been diverging.
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Return for Risk
2B78.DE vs. NQSE.DE — Risk / Return Rank
2B78.DE
NQSE.DE
2B78.DE vs. NQSE.DE - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for iShares Healthcare Innovation UCITS ETF (2B78.DE) and iShares NASDAQ 100 UCITS ETF (NQSE.DE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| 2B78.DE | NQSE.DE | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -1.32 | ||
| Sortino ratioReturn per unit of downside risk | -1.72 | ||
| Omega ratioGain probability vs. loss probability | 1.17 | 1.39 | -0.22 |
| Calmar ratioReturn relative to maximum drawdown | 1.24 | 3.08 | -1.84 |
| Martin ratioReturn relative to average drawdown | 3.07 | 10.77 | -7.70 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| 2B78.DE | NQSE.DE | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 0.95 | 2.28 | -1.32 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.10 | 0.71 | -0.80 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.31 | 0.82 | -0.51 |
Drawdowns
2B78.DE vs. NQSE.DE - Drawdown Comparison
The maximum 2B78.DE drawdown since its inception was -38.58%, roughly equal to the maximum NQSE.DE drawdown of -37.67%. Use the drawdown chart below to compare losses from any high point for 2B78.DE and NQSE.DE.
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Drawdown Indicators
| 2B78.DE | NQSE.DE | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -38.58% | -37.67% | -0.91% |
Max Drawdown (1Y)Largest decline over 1 year | -12.05% | -11.87% | -0.18% |
Max Drawdown (3Y)Largest decline over 3 years | -25.32% | -22.40% | -2.92% |
Max Drawdown (5Y)Largest decline over 5 years | -36.99% | -37.67% | +0.68% |
Current DrawdownCurrent decline from peak | -19.03% | -0.84% | -18.19% |
Average DrawdownAverage peak-to-trough decline | -14.36% | -8.56% | -5.80% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 4.86% | 3.40% | +1.46% |
Volatility
2B78.DE vs. NQSE.DE - Volatility Comparison
The current volatility for iShares Healthcare Innovation UCITS ETF (2B78.DE) is 3.74%, while iShares NASDAQ 100 UCITS ETF (NQSE.DE) has a volatility of 4.75%. This indicates that 2B78.DE experiences smaller price fluctuations and is considered to be less risky than NQSE.DE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| 2B78.DE | NQSE.DE | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 3.74% | 4.75% | -1.01% |
Volatility (6M)Calculated over the trailing 6-month period | 10.97% | 11.99% | -1.02% |
Volatility (1Y)Calculated over the trailing 1-year period | 15.67% | 16.05% | -0.38% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 17.91% | 20.91% | -3.00% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 18.79% | 21.54% | -2.75% |
2B78.DE vs. NQSE.DE - Expense Ratio Comparison
2B78.DE has a 0.40% expense ratio, which is higher than NQSE.DE's 0.33% expense ratio.
Dividends
2B78.DE vs. NQSE.DE - Dividend Comparison
Neither 2B78.DE nor NQSE.DE has paid dividends to shareholders.
Frequently Asked Questions
2B78.DE and NQSE.DE have a correlation of 0.39, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
On fees, NQSE.DE is cheaper at 0.33% per year. The better choice depends on whether you care most about return, fees, risk, or income.
NQSE.DE is cheaper with a 0.33% expense ratio, compared with 0.40% for 2B78.DE.
2B78.DE is categorized as Health & Biotech Equities, while NQSE.DE is Nasdaq-100. 2B78.DE tracks iSTOXX® FactSet Breakthrough Healthcare, while NQSE.DE tracks NASDAQ-100 Index. Their fees differ too: 0.40% for 2B78.DE and 0.33% for NQSE.DE.
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