2B78.DE vs. WRNA.DE
2B78.DE (iShares Healthcare Innovation UCITS ETF) and WRNA.DE (WisdomTree BioRevolution UCITS ETF USD Acc) are both Health & Biotech Equities funds - 2B78.DE tracks the iSTOXX® FactSet Breakthrough Healthcare while WRNA.DE tracks the WisdomTree BioRevolution ESG Screened. Both are passively managed. Over the past 3 years, 2B78.DE returned 2.27%/yr vs 0.92%/yr for WRNA.DE. Their correlation of 0.86 suggests significant overlap in exposure. 2B78.DE charges 0.40%/yr vs 0.45%/yr for WRNA.DE.
Performance
2B78.DE vs. WRNA.DE - Performance Comparison
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Returns By Period
In the year-to-date period, 2B78.DE achieves a -2.07% return, which is significantly lower than WRNA.DE's 10.48% return.
2B78.DE
- 1D
- 0.41%
- 1M
- 1.41%
- YTD
- -2.07%
- 6M
- -3.15%
- 1Y
- 14.42%
- 3Y*
- 2.27%
- 5Y*
- -1.74%
- 10Y*
- —
WRNA.DE
- 1D
- 4.08%
- 1M
- 4.18%
- YTD
- 10.48%
- 6M
- 10.41%
- 1Y
- 48.70%
- 3Y*
- 0.92%
- 5Y*
- —
- 10Y*
- —
2B78.DE vs. WRNA.DE - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | |
|---|---|---|---|---|---|---|
2B78.DE iShares Healthcare Innovation UCITS ETF | -2.07% | 5.50% | 7.24% | -0.29% | -19.03% | 0.64% |
WRNA.DE WisdomTree BioRevolution UCITS ETF USD Acc | 10.48% | 9.13% | -10.92% | -3.37% | -22.01% | -0.98% |
Correlation
The correlation between 2B78.DE and WRNA.DE is 0.75, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.75 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.82 |
Correlation (All Time) Calculated using the full available price history since Dec 10, 2021 | 0.86 |
The correlation between 2B78.DE and WRNA.DE shifts across timeframes, from 0.75 (1 year) to 0.86 (all time), reflecting how their relationship changes across market environments.
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Return for Risk
2B78.DE vs. WRNA.DE — Risk / Return Rank
2B78.DE
WRNA.DE
2B78.DE vs. WRNA.DE - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for iShares Healthcare Innovation UCITS ETF (2B78.DE) and WisdomTree BioRevolution UCITS ETF USD Acc (WRNA.DE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| 2B78.DE | WRNA.DE | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.80 | ||
| Sortino ratioReturn per unit of downside risk | -1.02 | ||
| Omega ratioGain probability vs. loss probability | 1.17 | 1.30 | -0.13 |
| Calmar ratioReturn relative to maximum drawdown | 1.24 | 3.61 | -2.37 |
| Martin ratioReturn relative to average drawdown | 3.07 | 9.63 | -6.56 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| 2B78.DE | WRNA.DE | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 0.95 | 1.75 | -0.80 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.10 | — | — |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.31 | -0.20 | +0.51 |
Drawdowns
2B78.DE vs. WRNA.DE - Drawdown Comparison
The maximum 2B78.DE drawdown since its inception was -38.58%, smaller than the maximum WRNA.DE drawdown of -52.35%. Use the drawdown chart below to compare losses from any high point for 2B78.DE and WRNA.DE.
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Drawdown Indicators
| 2B78.DE | WRNA.DE | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -38.58% | -52.35% | +13.77% |
Max Drawdown (1Y)Largest decline over 1 year | -12.05% | -13.42% | +1.37% |
Max Drawdown (3Y)Largest decline over 3 years | -25.32% | -40.06% | +14.74% |
Max Drawdown (5Y)Largest decline over 5 years | -36.99% | — | — |
Current DrawdownCurrent decline from peak | -19.03% | -20.73% | +1.70% |
Average DrawdownAverage peak-to-trough decline | -14.36% | -27.26% | +12.90% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 4.86% | 5.04% | -0.18% |
Volatility
2B78.DE vs. WRNA.DE - Volatility Comparison
The current volatility for iShares Healthcare Innovation UCITS ETF (2B78.DE) is 3.74%, while WisdomTree BioRevolution UCITS ETF USD Acc (WRNA.DE) has a volatility of 6.73%. This indicates that 2B78.DE experiences smaller price fluctuations and is considered to be less risky than WRNA.DE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| 2B78.DE | WRNA.DE | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 3.74% | 6.73% | -2.99% |
Volatility (6M)Calculated over the trailing 6-month period | 10.97% | 17.21% | -6.24% |
Volatility (1Y)Calculated over the trailing 1-year period | 15.67% | 27.70% | -12.03% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 17.91% | 24.22% | -6.31% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 18.79% | 24.22% | -5.43% |
2B78.DE vs. WRNA.DE - Expense Ratio Comparison
2B78.DE has a 0.40% expense ratio, which is lower than WRNA.DE's 0.45% expense ratio.
Dividends
2B78.DE vs. WRNA.DE - Dividend Comparison
Neither 2B78.DE nor WRNA.DE has paid dividends to shareholders.
Frequently Asked Questions
2B78.DE and WRNA.DE have a correlation of 0.75, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
On fees, 2B78.DE is cheaper at 0.40% per year. The better choice depends on whether you care most about return, fees, risk, or income.
2B78.DE is cheaper with a 0.40% expense ratio, compared with 0.45% for WRNA.DE.
2B78.DE tracks iSTOXX® FactSet Breakthrough Healthcare, while WRNA.DE tracks WisdomTree BioRevolution ESG Screened. They also come from different issuers: iShares and WisdomTree. Their fees differ too: 0.40% for 2B78.DE and 0.45% for WRNA.DE.
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