2B78.DE vs. CBUF.DE
2B78.DE (iShares Healthcare Innovation UCITS ETF) and CBUF.DE (iShares MSCI World Health Care Sector ESG UCITS ETF USD Dist) are both Health & Biotech Equities funds from iShares - 2B78.DE tracks the iSTOXX® FactSet Breakthrough Healthcare while CBUF.DE tracks the MSCI World Health Care ESG Reduced Carbon Select 20 35 Capped. Both are passively managed. Over the past 5 years, 2B78.DE returned -1.74%/yr vs 4.66%/yr for CBUF.DE. A 0.73 correlation means they provide meaningful diversification when combined. 2B78.DE charges 0.40%/yr vs 0.18%/yr for CBUF.DE.
Performance
2B78.DE vs. CBUF.DE - Performance Comparison
Loading charts...
Returns By Period
In the year-to-date period, 2B78.DE achieves a -2.07% return, which is significantly higher than CBUF.DE's -2.22% return.
2B78.DE
- 1D
- 0.41%
- 1M
- 1.41%
- YTD
- -2.07%
- 6M
- -3.15%
- 1Y
- 14.42%
- 3Y*
- 2.27%
- 5Y*
- -1.74%
- 10Y*
- —
CBUF.DE
- 1D
- 2.74%
- 1M
- 3.65%
- YTD
- -2.22%
- 6M
- -1.56%
- 1Y
- 7.33%
- 3Y*
- 0.62%
- 5Y*
- 4.66%
- 10Y*
- —
2B78.DE vs. CBUF.DE - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | |
|---|---|---|---|---|---|---|---|---|
2B78.DE iShares Healthcare Innovation UCITS ETF | -2.07% | 5.50% | 7.24% | -0.29% | -19.03% | 1.15% | 38.75% | 12.74% |
CBUF.DE iShares MSCI World Health Care Sector ESG UCITS ETF USD Dist | -2.22% | 2.56% | 0.75% | 0.33% | 2.09% | 30.42% | 2.79% | 11.42% |
Correlation
The correlation between 2B78.DE and CBUF.DE is 0.76, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.76 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.72 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.72 |
Correlation (All Time) Calculated using the full available price history since Oct 23, 2019 | 0.73 |
The correlation between 2B78.DE and CBUF.DE has been stable across timeframes, ranging from 0.72 to 0.76 - a consistent structural relationship.
Compare stocks, funds, or ETFs
Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.
Return for Risk
2B78.DE vs. CBUF.DE — Risk / Return Rank
2B78.DE
CBUF.DE
2B78.DE vs. CBUF.DE - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for iShares Healthcare Innovation UCITS ETF (2B78.DE) and iShares MSCI World Health Care Sector ESG UCITS ETF USD Dist (CBUF.DE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| 2B78.DE | CBUF.DE | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.43 | ||
| Sortino ratioReturn per unit of downside risk | +0.57 | ||
| Omega ratioGain probability vs. loss probability | 1.17 | 1.10 | +0.07 |
| Calmar ratioReturn relative to maximum drawdown | 1.24 | 0.68 | +0.56 |
| Martin ratioReturn relative to average drawdown | 3.07 | 1.56 | +1.51 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
Loading charts...
Sharpe Ratios by Period
| 2B78.DE | CBUF.DE | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 0.95 | 0.53 | +0.43 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.10 | 0.34 | -0.44 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.31 | 0.44 | -0.13 |
Drawdowns
2B78.DE vs. CBUF.DE - Drawdown Comparison
The maximum 2B78.DE drawdown since its inception was -38.58%, which is greater than CBUF.DE's maximum drawdown of -25.94%. Use the drawdown chart below to compare losses from any high point for 2B78.DE and CBUF.DE.
Loading charts...
Drawdown Indicators
| 2B78.DE | CBUF.DE | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -38.58% | -25.94% | -12.64% |
Max Drawdown (1Y)Largest decline over 1 year | -12.05% | -10.87% | -1.18% |
Max Drawdown (3Y)Largest decline over 3 years | -25.32% | -21.76% | -3.56% |
Max Drawdown (5Y)Largest decline over 5 years | -36.99% | -21.76% | -15.23% |
Current DrawdownCurrent decline from peak | -19.03% | -9.66% | -9.37% |
Average DrawdownAverage peak-to-trough decline | -14.36% | -5.65% | -8.71% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 4.86% | 4.74% | +0.12% |
Volatility
2B78.DE vs. CBUF.DE - Volatility Comparison
The current volatility for iShares Healthcare Innovation UCITS ETF (2B78.DE) is 3.74%, while iShares MSCI World Health Care Sector ESG UCITS ETF USD Dist (CBUF.DE) has a volatility of 4.98%. This indicates that 2B78.DE experiences smaller price fluctuations and is considered to be less risky than CBUF.DE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
Loading charts...
Volatility by Period
| 2B78.DE | CBUF.DE | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 3.74% | 4.98% | -1.24% |
Volatility (6M)Calculated over the trailing 6-month period | 10.97% | 9.70% | +1.27% |
Volatility (1Y)Calculated over the trailing 1-year period | 15.67% | 13.98% | +1.69% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 17.91% | 13.60% | +4.31% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 18.79% | 15.36% | +3.43% |
2B78.DE vs. CBUF.DE - Expense Ratio Comparison
2B78.DE has a 0.40% expense ratio, which is higher than CBUF.DE's 0.18% expense ratio.
Dividends
2B78.DE vs. CBUF.DE - Dividend Comparison
2B78.DE has not paid dividends to shareholders, while CBUF.DE's dividend yield for the trailing twelve months is around 1.08%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 |
|---|---|---|---|---|---|---|---|---|
2B78.DE iShares Healthcare Innovation UCITS ETF | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
CBUF.DE iShares MSCI World Health Care Sector ESG UCITS ETF USD Dist | 1.08% | 1.06% | 1.02% | 1.16% | 1.09% | 1.05% | 1.27% | 0.10% |
Frequently Asked Questions
2B78.DE and CBUF.DE have a correlation of 0.76, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
On fees, CBUF.DE is cheaper at 0.18% per year. The better choice depends on whether you care most about return, fees, risk, or income.
CBUF.DE is cheaper with a 0.18% expense ratio, compared with 0.40% for 2B78.DE.
2B78.DE tracks iSTOXX® FactSet Breakthrough Healthcare, while CBUF.DE tracks MSCI World Health Care ESG Reduced Carbon Select 20 35 Capped. Their fees differ too: 0.40% for 2B78.DE and 0.18% for CBUF.DE.
Find the right allocation for 2B78.DE and CBUF.DE
Add both to a portfolio and optimize allocations for your target — whether that's maximizing returns, minimizing drawdowns, or balancing risk across holdings.
Open Portfolio Optimizer