ALPS Medical Breakthroughs ETF (SBIO) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with SBIO. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to SBIO
SBIO charges 0.50% annually. There are 25 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | SBIO vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | SBIO vs XLV | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | SBIO vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | SBIO vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | SBIO vs GSKH |
Best Risk-Adjusted Alternatives to SBIO
SBIO has a PortfoliosLab risk / return rank of 95. There is 1 ETF in the Health & Biotech Equities category with a higher risk-adjusted rank, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | SBIO vs BBC | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | SBIO vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | SBIO vs IHE | |
| iShares Neuroscience and Healthcare ETF | 93 | 5.85M | Aug 2022 | SBIO vs IBRN | |
| First Trust Nasdaq Pharmaceuticals ETF | 93 | 36.36M | Sep 2016 | SBIO vs FTXH |
Top Performing SBIO Alternatives (YTD)
SBIO is at 27.56% YTD. There are 4 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 40.11%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 40.11% | 1.31B | Oct 2014 | SBIO vs ARKG | |
| AdvisorShares Psychedelics ETF | 35.29% | 44.37M | Sep 2021 | SBIO vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 34.33% | 6.01M | Dec 2025 | SBIO vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.14% | 57.56M | Dec 2014 | SBIO vs BBC | |
| SPDR S&P Biotech ETF | 27.53% | 11.10B | Feb 2006 | SBIO vs XBI |
Lowest Volatility Alternatives to SBIO
SBIO has 30.65% 1-year volatility. There are 60 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | SBIO vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | SBIO vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.64% | 10.11M | Jun 2007 | SBIO vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.87% | 16.78M | Jul 2025 | SBIO vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.73% | 982.35K | Apr 2026 | SBIO vs MHIP |
Lowest Drawdown Alternatives to SBIO
SBIO has a 1-year max drawdown of -12.66%. There are 33 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | SBIO vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | SBIO vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | SBIO vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | SBIO vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | SBIO vs IHE |
Other ETFs from SS&C
The 10 most viewed SS&C ETFs shown here include AMLP, ENFR, EQL and span 11 categories. AUM among these funds goes as high as $12B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Alerian MLP ETF | MLPs | 54 | 18.74% | 12.42B | Aug 2010 | SBIO vs AMLP | |
| Alerian Energy Infrastructure ETF | Energy Equities | 77 | 28.57% | 479.43M | Oct 2013 | SBIO vs ENFR | |
| ALPS Equal Sector Weight ETF | Large Cap Blend Equities | 69 | 10.57% | 747.14M | Jul 2009 | SBIO vs EQL | |
| ALPS Sector Dividend Dogs ETF | Large Cap Value Equities, Dividend | 83 | 18.72% | 1.38B | Jun 2012 | SBIO vs SDOG | |
| ALPS Clean Energy ETF | Alternative Energy Equities | 22 | 0.52% | 118.97M | Jun 2018 | SBIO vs ACES | |
| ALPS International Sector Dividend Dogs ETF | Foreign Large Cap Equities, Dividend | 81 | 11.75% | 523.46M | Jun 2013 | SBIO vs IDOG | |
| ALPS REIT Dividend Dogs ETF | REIT, Dividend | 53 | 19.31% | 11.37M | May 2008 | SBIO vs RDOG | |
| ALPS Barron's 400 ETF | Mid Cap Blend Equities | 57 | 14.23% | 227.31M | Jun 2013 | SBIO vs BFOR | |
| ALPS Disruptive Technologies ETF | Technology Equities | 9 | 0.32% | 70.68M | Dec 2017 | SBIO vs DTEC | |
| RiverFront Dynamic US Dividend Advantage ETF | Large Cap Growth Equities, Dividend | 86 | 13.64% | 87.62M | Jun 2016 | SBIO vs RFDA |
Often Compared With SBIO
Investors most often compare SBIO with BBP, IBB, PBE. These 20 comparison targets span 5 categories, based on PortfoliosLab usage data.
Compare SBIO with Any Fund or Stock
Compare SBIO with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair SBIO with funds that move differently
ALPS Medical Breakthroughs ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to SBIO.
Explore SBIO Diversifiers