SBIO vs. BBC

Last updated Apr 2, 2026

Compare and contrast key facts about ALPS Medical Breakthroughs ETF (SBIO) and Virtus LifeSci Biotech Clinical Trials ETF (BBC).

SBIO and BBC are both exchange-traded funds (ETFs), meaning they are traded on stock exchanges and can be bought and sold throughout the day. SBIO is a passively managed fund by SS&C that tracks the performance of the S-Network Medical Breakthroughs Index. It was launched on Dec 31, 2014. BBC is a passively managed fund by Virtus Investment Partners that tracks the performance of the LifeSci Biotechnology Clinical Trials Index. It was launched on Dec 16, 2014. Both SBIO and BBC are passive ETFs, meaning that they are not actively managed but aim to replicate the performance of the underlying index as closely as possible.

Performance

SBIO vs. BBC - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ALPS Medical Breakthroughs ETF (SBIO) and Virtus LifeSci Biotech Clinical Trials ETF (BBC). The values are adjusted to include any dividend payments, if applicable.

SBIO vs. BBC - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
SBIO ALPS Medical Breakthroughs ETF	3.20%	55.07%	3.81%	8.68%	-28.08%	-17.55%	21.17%	50.30%	-11.81%	45.67%
BBC Virtus LifeSci Biotech Clinical Trials ETF	10.01%	63.77%	-1.11%	-1.80%	-35.13%	-22.31%	30.32%	63.81%	-18.29%	57.85%

Returns By Period

In the year-to-date period, SBIO achieves a 3.20% return, which is significantly lower than BBC's 10.01% return. Over the past 10 years, SBIO has outperformed BBC with an annualized return of 9.75%, while BBC has yielded a comparatively lower 8.62% annualized return.

SBIO

• 1D: 0.99%
• 1M: 3.89%
• YTD: 3.20%
• 6M: 36.23%
• 1Y: 95.78%
• 3Y*: 26.37%
• 5Y*: 1.76%
• 10Y*: 9.75%

BBC

• 1D: 1.91%
• 1M: 0.45%
• YTD: 10.01%
• 6M: 58.07%
• 1Y: 160.96%
• 3Y*: 25.88%
• 5Y*: -3.27%
• 10Y*: 8.62%

*Multi-year figures are annualized to reflect compound growth (CAGR)

SBIO vs. BBC - Expense Ratio Comparison

SBIO has a 0.50% expense ratio, which is lower than BBC's 0.79% expense ratio.

BBC

Virtus LifeSci Biotech Clinical Trials ETF

SBIO

ALPS Medical Breakthroughs ETF

Return for Risk

SBIO vs. BBC — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SBIO

SBIO Risk / Return Rank: 96
SBIO Sharpe Ratio Rank: 97
SBIO Sortino Ratio Rank: 97
SBIO Omega Ratio Rank: 94
SBIO Calmar Ratio Rank: 98
SBIO Martin Ratio Rank: 97

BBC

BBC Risk / Return Rank: 98
BBC Sharpe Ratio Rank: 99
BBC Sortino Ratio Rank: 98
BBC Omega Ratio Rank: 96
BBC Calmar Ratio Rank: 98
BBC Martin Ratio Rank: 98

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SBIO vs. BBC - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ALPS Medical Breakthroughs ETF (SBIO) and Virtus LifeSci Biotech Clinical Trials ETF (BBC). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	SBIO	BBC	Difference
Sharpe ratio Return per unit of total volatility	2.92	4.05	-1.13
Sortino ratio Return per unit of downside risk	3.57	4.28	-0.70
Omega ratio Gain probability vs. loss probability	1.45	1.53	-0.08
Calmar ratio Return relative to maximum drawdown	5.66	8.09	-2.44
Martin ratio Return relative to average drawdown	19.94	29.69	-9.75
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

SBIO vs. BBC - Sharpe Ratio Comparison

The current SBIO Sharpe Ratio is 2.92, which is comparable to the BBC Sharpe Ratio of 4.05. The chart below compares the historical Sharpe Ratios of SBIO and BBC, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	SBIO	BBC	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.92	4.05	-1.13
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.05	-0.08	+0.14
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.29	0.23	+0.07
Sharpe Ratio (All Time) Calculated using the full available price history	0.23	0.12	+0.11

Correlation

The correlation between SBIO and BBC is 0.94, which is considered to be high. That indicates a strong positive relationship between their price movements. Having highly-correlated positions in a portfolio may signal a lack of diversification, potentially leading to increased risk during market downturns.

Dividends

SBIO vs. BBC - Dividend Comparison

SBIO has not paid dividends to shareholders, while BBC's dividend yield for the trailing twelve months is around 1.55%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%	0.00%	0.00%
BBC Virtus LifeSci Biotech Clinical Trials ETF	1.55%	1.70%	1.00%	0.34%	0.00%	0.00%	0.00%	0.00%	0.00%	2.09%	0.00%	0.51%

Drawdowns

SBIO vs. BBC - Drawdown Comparison

The maximum SBIO drawdown since its inception was -63.06%, smaller than the maximum BBC drawdown of -76.85%. Use the drawdown chart below to compare losses from any high point for SBIO and BBC.

Drawdown Indicators

	SBIO	BBC	Difference
Max Drawdown Largest peak-to-trough decline	-63.06%	-76.85%	+13.79%
Max Drawdown (1Y) Largest decline over 1 year	-15.08%	-18.03%	+2.95%
Max Drawdown (5Y) Largest decline over 5 years	-53.67%	-72.58%	+18.91%
Max Drawdown (10Y) Largest decline over 10 years	-63.06%	-76.85%	+13.79%
Current Drawdown Current decline from peak	-13.79%	-29.38%	+15.59%
Average Drawdown Average peak-to-trough decline	-28.70%	-37.30%	+8.60%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.28%	4.91%	-0.63%

Volatility

SBIO vs. BBC - Volatility Comparison

ALPS Medical Breakthroughs ETF (SBIO) and Virtus LifeSci Biotech Clinical Trials ETF (BBC) have volatilities of 12.61% and 13.12%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SBIO	BBC	Difference
Volatility (1M) Calculated over the trailing 1-month period	12.61%	13.12%	-0.51%
Volatility (6M) Calculated over the trailing 6-month period	22.09%	26.96%	-4.87%
Volatility (1Y) Calculated over the trailing 1-year period	33.43%	40.44%	-7.01%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	33.55%	39.31%	-5.76%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	33.34%	37.86%	-4.52%