SBIO vs. IBRN
Compare and contrast key facts about ALPS Medical Breakthroughs ETF (SBIO) and iShares Neuroscience and Healthcare ETF (IBRN).
SBIO and IBRN are both exchange-traded funds (ETFs), meaning they are traded on stock exchanges and can be bought and sold throughout the day. SBIO is a passively managed fund by SS&C that tracks the performance of the S-Network Medical Breakthroughs Index. It was launched on Dec 31, 2014. IBRN is a passively managed fund by iShares that tracks the performance of the NYSE FactSet Global Neuro Biopharma and MedTech Index. It was launched on Aug 24, 2022. Both SBIO and IBRN are passive ETFs, meaning that they are not actively managed but aim to replicate the performance of the underlying index as closely as possible.
Performance
SBIO vs. IBRN - Performance Comparison
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SBIO vs. IBRN - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
SBIO ALPS Medical Breakthroughs ETF | 3.20% | 55.07% | 3.81% | 8.68% | -5.36% |
IBRN iShares Neuroscience and Healthcare ETF | 2.99% | 28.49% | -2.78% | 0.92% | 5.85% |
Returns By Period
In the year-to-date period, SBIO achieves a 3.20% return, which is significantly higher than IBRN's 2.99% return.
SBIO
- 1D
- 0.99%
- 1M
- 3.89%
- YTD
- 3.20%
- 6M
- 36.23%
- 1Y
- 95.78%
- 3Y*
- 26.37%
- 5Y*
- 1.76%
- 10Y*
- 9.75%
IBRN
- 1D
- 1.00%
- 1M
- 4.90%
- YTD
- 2.99%
- 6M
- 25.12%
- 1Y
- 56.67%
- 3Y*
- 12.28%
- 5Y*
- —
- 10Y*
- —
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SBIO vs. IBRN - Expense Ratio Comparison
SBIO has a 0.50% expense ratio, which is higher than IBRN's 0.47% expense ratio.
Return for Risk
SBIO vs. IBRN — Risk / Return Rank
SBIO
IBRN
SBIO vs. IBRN - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for ALPS Medical Breakthroughs ETF (SBIO) and iShares Neuroscience and Healthcare ETF (IBRN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| SBIO | IBRN | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | 2.92 | 1.96 | +0.96 |
Sortino ratioReturn per unit of downside risk | 3.57 | 2.64 | +0.93 |
Omega ratioGain probability vs. loss probability | 1.45 | 1.33 | +0.12 |
Calmar ratioReturn relative to maximum drawdown | 5.66 | 3.27 | +2.39 |
Martin ratioReturn relative to average drawdown | 19.94 | 11.55 | +8.39 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| SBIO | IBRN | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 2.92 | 1.96 | +0.96 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.05 | — | — |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.29 | — | — |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.23 | 0.37 | -0.14 |
Correlation
The correlation between SBIO and IBRN is 0.88, which is considered to be high. That indicates a strong positive relationship between their price movements. Having highly-correlated positions in a portfolio may signal a lack of diversification, potentially leading to increased risk during market downturns.
Dividends
SBIO vs. IBRN - Dividend Comparison
SBIO has not paid dividends to shareholders, while IBRN's dividend yield for the trailing twelve months is around 0.96%.
| TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
SBIO ALPS Medical Breakthroughs ETF | 0.00% | 0.00% | 3.55% | 0.22% | 0.00% | 0.00% | 0.00% | 0.04% | 2.79% | 1.77% |
IBRN iShares Neuroscience and Healthcare ETF | 0.96% | 0.99% | 0.40% | 0.06% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
Drawdowns
SBIO vs. IBRN - Drawdown Comparison
The maximum SBIO drawdown since its inception was -63.06%, which is greater than IBRN's maximum drawdown of -35.38%. Use the drawdown chart below to compare losses from any high point for SBIO and IBRN.
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Drawdown Indicators
| SBIO | IBRN | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -63.06% | -35.38% | -27.68% |
Max Drawdown (1Y)Largest decline over 1 year | -15.08% | -15.44% | +0.36% |
Max Drawdown (5Y)Largest decline over 5 years | -53.67% | — | — |
Max Drawdown (10Y)Largest decline over 10 years | -63.06% | — | — |
Current DrawdownCurrent decline from peak | -13.79% | -0.74% | -13.05% |
Average DrawdownAverage peak-to-trough decline | -28.70% | -10.19% | -18.51% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 4.28% | 4.37% | -0.09% |
Volatility
SBIO vs. IBRN - Volatility Comparison
ALPS Medical Breakthroughs ETF (SBIO) and iShares Neuroscience and Healthcare ETF (IBRN) have volatilities of 12.61% and 12.02%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| SBIO | IBRN | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 12.61% | 12.02% | +0.59% |
Volatility (6M)Calculated over the trailing 6-month period | 22.09% | 19.63% | +2.46% |
Volatility (1Y)Calculated over the trailing 1-year period | 33.43% | 29.38% | +4.05% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 33.55% | 25.39% | +8.16% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 33.34% | 25.39% | +7.95% |