SBIO vs. ENFR

Last updated Jun 5, 2026

SBIO (ALPS Medical Breakthroughs ETF) and ENFR (Alerian Energy Infrastructure ETF) are both exchange-traded funds - SBIO is a Health & Biotech Equities fund tracking the S-Network Medical Breakthroughs Index, while ENFR is a Energy Equities fund tracking the Alerian Midstream Energy Select Index. Both are passively managed. Over the past 10 years, SBIO returned 8.03%/yr vs 11.90%/yr for ENFR. At a 0.29 correlation, their price movements are largely independent. SBIO charges 0.50%/yr vs 0.35%/yr for ENFR.

Performance

SBIO vs. ENFR - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ALPS Medical Breakthroughs ETF (SBIO) and Alerian Energy Infrastructure ETF (ENFR). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, SBIO achieves a 1.95% return, which is significantly lower than ENFR's 26.03% return. Over the past 10 years, SBIO has underperformed ENFR with an annualized return of 8.03%, while ENFR has yielded a comparatively higher 11.90% annualized return.

SBIO

• 1D: 2.35%
• 1M: -5.55%
• YTD: 1.95%
• 6M: 4.13%
• 1Y: 68.86%
• 3Y*: 18.38%
• 5Y*: 3.16%
• 10Y*: 8.03%

ENFR

• 1D: 1.15%
• 1M: 0.77%
• YTD: 26.03%
• 6M: 24.35%
• 1Y: 28.57%
• 3Y*: 28.54%
• 5Y*: 20.19%
• 10Y*: 11.90%

*Multi-year figures are annualized to reflect compound growth (CAGR)

SBIO vs. ENFR - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
SBIO ALPS Medical Breakthroughs ETF	1.95%	55.07%	3.81%	8.68%	-28.08%	-17.55%	21.17%	50.30%	-11.81%	45.67%
ENFR Alerian Energy Infrastructure ETF	26.03%	5.88%	42.17%	15.63%	17.48%	39.97%	-24.14%	21.60%	-18.67%	-0.19%

Correlation

The correlation between SBIO and ENFR is -0.04, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.04
Correlation (3Y) Calculated over the trailing 3-year period	0.15
Correlation (5Y) Calculated over the trailing 5-year period	0.25
Correlation (10Y) Calculated over the trailing 10-year period	0.30
Correlation (All Time) Calculated using the full available price history since Jan 2, 2015	0.29

The correlation between SBIO and ENFR shifts across timeframes, from -0.04 (1 year) to 0.30 (10 years), reflecting how their relationship changes across market environments.

SBIO vs. ENFR - Sectors Allocation Comparison

Sectors	SBIO	ENFR
Healthcare	100.0%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	98.8%
Industrials	-	3.4%
Real Estate	-	-
Technology	-	-
Utilities	-	1.0%
Financial Services	-0.0%	0.2%

Return for Risk

SBIO vs. ENFR — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SBIO

SBIO Risk / Return Rank: 76
SBIO Sharpe Ratio Rank: 74
SBIO Sortino Ratio Rank: 72
SBIO Omega Ratio Rank: 63
SBIO Calmar Ratio Rank: 90
SBIO Martin Ratio Rank: 82

ENFR

ENFR Risk / Return Rank: 59
ENFR Sharpe Ratio Rank: 59
ENFR Sortino Ratio Rank: 57
ENFR Omega Ratio Rank: 56
ENFR Calmar Ratio Rank: 68
ENFR Martin Ratio Rank: 53

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SBIO vs. ENFR - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ALPS Medical Breakthroughs ETF (SBIO) and Alerian Energy Infrastructure ETF (ENFR). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	SBIO	ENFR	Difference
Sharpe ratio: Return per unit of total volatility	2.35	1.97	+0.39
Sortino ratio: Return per unit of downside risk	3.22	2.68	+0.54
Omega ratio: Gain probability vs. loss probability	1.38	1.34	+0.04
Calmar ratio: Return relative to maximum drawdown	5.47	3.32	+2.15
Martin ratio: Return relative to average drawdown	16.23	9.04	+7.19
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

SBIO vs. ENFR - Sharpe Ratio Comparison

The current SBIO Sharpe Ratio is 2.35, which is comparable to the ENFR Sharpe Ratio of 1.97. The chart below compares the historical Sharpe Ratios of SBIO and ENFR, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	SBIO	ENFR	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.35	1.97	+0.39
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.09	1.05	-0.96
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.24	0.48	-0.24
Sharpe Ratio (All Time) Calculated using the full available price history	0.22	0.35	-0.13

Drawdowns

SBIO vs. ENFR - Drawdown Comparison

The maximum SBIO drawdown since its inception was -63.06%, smaller than the maximum ENFR drawdown of -68.28%. Use the drawdown chart below to compare losses from any high point for SBIO and ENFR.

Drawdown Indicators

	SBIO	ENFR	Difference
Max Drawdown Largest peak-to-trough decline	-63.06%	-68.28%	+5.22%
Max Drawdown (1Y) Largest decline over 1 year	-12.66%	-8.64%	-4.02%
Max Drawdown (3Y) Largest decline over 3 years	-42.44%	-15.58%	-26.86%
Max Drawdown (5Y) Largest decline over 5 years	-53.10%	-20.29%	-32.81%
Max Drawdown (10Y) Largest decline over 10 years	-63.06%	-62.64%	-0.42%
Current Drawdown Current decline from peak	-14.84%	-3.86%	-10.98%
Average Drawdown Average peak-to-trough decline	-28.44%	-15.98%	-12.46%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.26%	3.17%	+1.09%

Volatility

SBIO vs. ENFR - Volatility Comparison

ALPS Medical Breakthroughs ETF (SBIO) has a higher volatility of 9.85% compared to Alerian Energy Infrastructure ETF (ENFR) at 6.25%. This indicates that SBIO's price experiences larger fluctuations and is considered to be riskier than ENFR based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SBIO	ENFR	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.85%	6.25%	+3.60%
Volatility (6M) Calculated over the trailing 6-month period	22.76%	11.42%	+11.34%
Volatility (1Y) Calculated over the trailing 1-year period	29.40%	14.65%	+14.75%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	33.57%	19.30%	+14.27%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	33.18%	24.68%	+8.50%

SBIO vs. ENFR - Expense Ratio Comparison

SBIO has a 0.50% expense ratio, which is higher than ENFR's 0.35% expense ratio.

Dividends

SBIO vs. ENFR - Dividend Comparison

SBIO has not paid dividends to shareholders, while ENFR's dividend yield for the trailing twelve months is around 3.98%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
ENFR Alerian Energy Infrastructure ETF	3.98%	4.77%	4.41%	5.48%	5.23%	7.86%	7.57%	5.81%	3.98%	2.98%	3.31%	3.34%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%	0.00%	0.00%

Frequently Asked Questions

Can I hold both SBIO and ENFR in my portfolio?

SBIO and ENFR have a correlation of -0.04, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, SBIO or ENFR?

SBIO has higher volatility (9.85%) compared to ENFR (6.25%). In terms of maximum drawdown, SBIO dropped -63.06% vs ENFR's -68.28%.

Which ETF is better, SBIO or ENFR?

On 10-year performance, ENFR leads with 11.90% vs 8.03% for SBIO. On fees, ENFR is cheaper at 0.35% per year. On volatility, ENFR has been the lower-risk option at 6.25%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, SBIO or ENFR?

Over the 10-year period, ENFR has performed better with a 11.90% return vs 8.03%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, SBIO or ENFR?

ENFR is cheaper with a 0.35% expense ratio, compared with 0.50% for SBIO.

Which ETF pays a higher dividend yield, SBIO or ENFR?

ENFR has the higher dividend yield at 3.98%, compared with 0.00% for SBIO.

What is the main difference between SBIO and ENFR?

SBIO is categorized as Health & Biotech Equities, while ENFR is Energy Equities. SBIO tracks S-Network Medical Breakthroughs Index, while ENFR tracks Alerian Midstream Energy Select Index. Their fees differ too: 0.50% for SBIO and 0.35% for ENFR.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (2.35 vs 1.97), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.