SBIO vs. TMED

Last updated Aug 4, 2026

SBIO (ALPS Medical Breakthroughs ETF) and TMED (T. Rowe Price Health Care ETF) are both Health & Biotech Equities funds. SBIO is passively managed, while TMED is actively managed. Over the past year, SBIO returned 94.30% vs 41.69% for TMED. Their 0.68 correlation means they have sometimes moved together and sometimes differently. SBIO charges 0.50%/yr vs 0.44%/yr for TMED.

Performance

SBIO vs. TMED - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ALPS Medical Breakthroughs ETF (SBIO) and T. Rowe Price Health Care ETF (TMED). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, SBIO achieves a 24.03% return, which is significantly higher than TMED's 14.31% return.

SBIO

• 1D: 0.26%
• 1M: -2.12%
• 6M: 20.98%
• YTD: 24.03%
• 1Y: 94.30%
• 3Y*: 28.61%
• 5Y*: 8.57%
• 10Y*: 10.42%
• ALL TIME*: 9.15%

TMED

• 1D: 0.28%
• 1M: -2.90%
• 6M: 13.93%
• YTD: 14.31%
• 1Y: 41.69%
• 3Y*: —
• 5Y*: —
• 10Y*: —
• ALL TIME*: 31.40%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
SBIO ALPS Medical Breakthroughs ETF	$2.14M	$3.25M	$2.22M
TMED T. Rowe Price Health Care ETF	$590.48K	$387.83K	$177.93K

SBIO vs. TMED - Yearly Performance Comparison

	2026 (YTD)	2025
SBIO ALPS Medical Breakthroughs ETF	24.03%	64.22%
TMED T. Rowe Price Health Care ETF	14.31%	19.49%

Correlation

The correlation between SBIO and TMED is 0.69, which is moderate. They have sometimes moved together and sometimes differently, sharing some price drivers without tracking each other closely.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.69
Correlation (All Time) Calculated using the full available price history since Jun 12, 2025	0.68

The correlation between SBIO and TMED has been stable across timeframes, ranging from 0.68 to 0.69 - a consistent structural relationship.

Return for Risk

SBIO vs. TMED — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

SBIO

SBIO Risk / Return Rank: 95
SBIO Sharpe Ratio Rank: 96
SBIO Sortino Ratio Rank: 94
SBIO Omega Ratio Rank: 92
SBIO Calmar Ratio Rank: 97
SBIO Martin Ratio Rank: 94

TMED

TMED Risk / Return Rank: 87
TMED Sharpe Ratio Rank: 88
TMED Sortino Ratio Rank: 89
TMED Omega Ratio Rank: 85
TMED Calmar Ratio Rank: 87
TMED Martin Ratio Rank: 84

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

SBIO vs. TMED - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ALPS Medical Breakthroughs ETF (SBIO) and T. Rowe Price Health Care ETF (TMED). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	SBIO	TMED	Difference
Sharpe ratio: Return per unit of total volatility	3.06	2.29	+0.76
Sortino ratio: Return per unit of downside risk	3.84	3.32	+0.52
Omega ratio: Gain probability vs. loss probability	1.45	1.39	+0.06
Calmar ratio: Return relative to maximum drawdown	7.49	3.77	+3.72
Martin ratio: Return relative to average drawdown	19.63	12.83	+6.79

SBIO vs. TMED - Sharpe Ratio Comparison

The current SBIO Sharpe Ratio is 3.06, which is higher than the TMED Sharpe Ratio of 2.29. The chart below compares the historical Sharpe Ratios of SBIO and TMED, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

SBIO vs. TMED - Drawdown Comparison

The maximum SBIO drawdown since its inception was -63.06%, which is greater than TMED's maximum drawdown of -11.11%. Use the drawdown chart below to compare losses from any high point for SBIO and TMED.

Drawdown Indicators

	SBIO	TMED	Difference
Max Drawdown Largest peak-to-trough decline	-63.06%	-11.11%	-51.95%
Max Drawdown (1Y) Largest decline over 1 year	-12.66%	-11.11%	-1.55%
Max Drawdown (3Y) Largest decline over 3 years	-42.44%	—	—
Max Drawdown (5Y) Largest decline over 5 years	-52.49%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-63.06%	—	—
Current Drawdown Current decline from peak	-7.85%	-3.98%	-3.87%
Average Drawdown Average peak-to-trough decline	-28.13%	-2.42%	-25.71%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.82%	3.26%	+1.56%

Volatility

SBIO vs. TMED - Volatility Comparison

ALPS Medical Breakthroughs ETF (SBIO) has a higher volatility of 9.73% compared to T. Rowe Price Health Care ETF (TMED) at 4.81%. This indicates that SBIO's price experiences larger fluctuations and is considered to be riskier than TMED based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SBIO	TMED	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.73%	4.81%	+4.92%
Volatility (6M) Calculated over the trailing 6-month period	24.05%	14.06%	+9.99%
Volatility (1Y) Calculated over the trailing 1-year period	31.08%	18.29%	+12.79%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	33.88%	18.11%	+15.77%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	33.19%	18.11%	+15.08%

SBIO vs. TMED - Expense Ratio Comparison

SBIO has a 0.50% expense ratio, which is higher than TMED's 0.44% expense ratio.

Dividends

SBIO vs. TMED - Dividend Comparison

SBIO has not paid dividends to shareholders, while TMED's dividend yield for the trailing twelve months is around 0.48%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%
TMED T. Rowe Price Health Care ETF	0.48%	0.54%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both SBIO and TMED in my portfolio?

SBIO and TMED have a correlation of 0.69, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, SBIO or TMED?

SBIO has higher volatility (9.73%) compared to TMED (4.81%). In terms of maximum drawdown, SBIO dropped -63.06% vs TMED's -11.11%.

Which ETF is better, SBIO or TMED?

On 1-year performance, SBIO leads with 94.30% vs 41.69% for TMED. On fees, TMED is cheaper at 0.44% per year. On volatility, TMED has been the lower-risk option at 4.81%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, SBIO or TMED?

Over the 1-year period, SBIO has performed better with a 94.30% return vs 41.69%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, SBIO or TMED?

TMED is cheaper with a 0.44% expense ratio, compared with 0.50% for SBIO.

Which ETF pays a higher dividend yield, SBIO or TMED?

TMED has the higher dividend yield at 0.48%, compared with 0.00% for SBIO.

What is the main difference between SBIO and TMED?

They also come from different issuers: SS&C and T. Rowe Price. Their fees differ too: 0.50% for SBIO and 0.44% for TMED.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (3.06 vs 2.29), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.