SBIO vs. PBPH
SBIO (ALPS Medical Breakthroughs ETF) and PBPH (Portfolio Building Block World Pharma and Biotech Index ETF) are both Health & Biotech Equities funds - SBIO tracks the S-Network Medical Breakthroughs Index while PBPH tracks the BITA Global Pharma and Biotech Select Index. Both are passively managed. A 0.57 correlation means they provide meaningful diversification when combined. SBIO charges 0.50%/yr vs 0.13%/yr for PBPH.
Performance
SBIO vs. PBPH - Performance Comparison
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Returns By Period
In the year-to-date period, SBIO achieves a -0.39% return, which is significantly higher than PBPH's -1.13% return.
SBIO
- 1D
- 1.41%
- 1M
- -7.56%
- YTD
- -0.39%
- 6M
- 3.05%
- 1Y
- 65.41%
- 3Y*
- 17.80%
- 5Y*
- 2.68%
- 10Y*
- 8.02%
PBPH
- 1D
- 0.58%
- 1M
- 0.07%
- YTD
- -1.13%
- 6M
- -0.02%
- 1Y
- —
- 3Y*
- —
- 5Y*
- —
- 10Y*
- —
SBIO vs. PBPH - Yearly Performance Comparison
| 2026 (YTD) | 2025 | |
|---|---|---|
SBIO ALPS Medical Breakthroughs ETF | -0.39% | 4.81% |
PBPH Portfolio Building Block World Pharma and Biotech Index ETF | -1.13% | 0.76% |
Correlation
The correlation between SBIO and PBPH is 0.57, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.
| Correlation | |
|---|---|
Correlation (All Time) Calculated using the full available price history since Nov 26, 2025 | 0.57 |
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Return for Risk
SBIO vs. PBPH — Risk / Return Rank
SBIO
PBPH
SBIO vs. PBPH - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for ALPS Medical Breakthroughs ETF (SBIO) and Portfolio Building Block World Pharma and Biotech Index ETF (PBPH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| SBIO | PBPH | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | — | — | |
| Sortino ratioReturn per unit of downside risk | — | — | |
| Omega ratioGain probability vs. loss probability | 1.36 | — | — |
| Calmar ratioReturn relative to maximum drawdown | 5.19 | — | — |
| Martin ratioReturn relative to average drawdown | 15.57 | — | — |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| SBIO | PBPH | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 2.24 | — | — |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.08 | — | — |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.24 | — | — |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.21 | -0.04 | +0.26 |
Drawdowns
SBIO vs. PBPH - Drawdown Comparison
The maximum SBIO drawdown since its inception was -63.06%, which is greater than PBPH's maximum drawdown of -11.10%. Use the drawdown chart below to compare losses from any high point for SBIO and PBPH.
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Drawdown Indicators
| SBIO | PBPH | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -63.06% | -11.10% | -51.96% |
Max Drawdown (1Y)Largest decline over 1 year | -12.66% | — | — |
Max Drawdown (3Y)Largest decline over 3 years | -42.44% | — | — |
Max Drawdown (5Y)Largest decline over 5 years | -53.10% | — | — |
Max Drawdown (10Y)Largest decline over 10 years | -63.06% | — | — |
Current DrawdownCurrent decline from peak | -16.79% | -8.69% | -8.10% |
Average DrawdownAverage peak-to-trough decline | -28.45% | -4.23% | -24.22% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 4.22% | — | — |
Volatility
SBIO vs. PBPH - Volatility Comparison
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Volatility by Period
| SBIO | PBPH | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 9.48% | — | — |
Volatility (6M)Calculated over the trailing 6-month period | 22.70% | — | — |
Volatility (1Y)Calculated over the trailing 1-year period | 29.42% | 16.78% | +12.64% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 33.56% | 16.78% | +16.78% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 33.17% | 16.78% | +16.39% |
SBIO vs. PBPH - Expense Ratio Comparison
SBIO has a 0.50% expense ratio, which is higher than PBPH's 0.13% expense ratio.
Dividends
SBIO vs. PBPH - Dividend Comparison
SBIO has not paid dividends to shareholders, while PBPH's dividend yield for the trailing twelve months is around 0.09%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
PBPH Portfolio Building Block World Pharma and Biotech Index ETF | 0.09% | 0.09% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
SBIO ALPS Medical Breakthroughs ETF | 0.00% | 0.00% | 3.55% | 0.22% | 0.00% | 0.00% | 0.00% | 0.04% | 2.79% | 1.77% |
Frequently Asked Questions
SBIO and PBPH have a correlation of 0.57, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
On fees, PBPH is cheaper at 0.13% per year. The better choice depends on whether you care most about return, fees, risk, or income.
PBPH is cheaper with a 0.13% expense ratio, compared with 0.50% for SBIO.
PBPH has the higher dividend yield at 0.09%, compared with 0.00% for SBIO.
SBIO tracks S-Network Medical Breakthroughs Index, while PBPH tracks BITA Global Pharma and Biotech Select Index. They also come from different issuers: SS&C and Portfolio Building Block. Their fees differ too: 0.50% for SBIO and 0.13% for PBPH.
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