SBIO vs. XLVI

Last updated Jun 5, 2026

SBIO (ALPS Medical Breakthroughs ETF) and XLVI (State Street Health Care Select Sector SPDR Premium Income ETF) are both exchange-traded funds - SBIO is a Health & Biotech Equities fund tracking the S-Network Medical Breakthroughs Index, while XLVI is a Derivative Income fund actively managed by State Street. SBIO is passively managed, while XLVI is actively managed. At a 0.45 correlation, their price movements are largely independent. SBIO charges 0.50%/yr vs 0.35%/yr for XLVI.

Performance

SBIO vs. XLVI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ALPS Medical Breakthroughs ETF (SBIO) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, SBIO achieves a 1.95% return, which is significantly higher than XLVI's 1.35% return.

SBIO

• 1D: 2.35%
• 1M: -5.55%
• YTD: 1.95%
• 6M: 4.13%
• 1Y: 68.86%
• 3Y*: 18.38%
• 5Y*: 3.16%
• 10Y*: 8.03%

XLVI

• 1D: 2.03%
• 1M: 4.01%
• YTD: 1.35%
• 6M: 3.19%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

SBIO vs. XLVI - Yearly Performance Comparison

	2026 (YTD)	2025
SBIO ALPS Medical Breakthroughs ETF	1.95%	55.40%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	1.35%	12.79%

Correlation

The correlation between SBIO and XLVI is 0.45, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (All Time) Calculated using the full available price history since Jul 31, 2025	0.45

SBIO vs. XLVI - Sectors Allocation Comparison

Sectors	SBIO	XLVI
Healthcare	100.0%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-
Financial Services	-0.0%	100.6%

Return for Risk

SBIO vs. XLVI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SBIO

SBIO Risk / Return Rank: 76
SBIO Sharpe Ratio Rank: 74
SBIO Sortino Ratio Rank: 72
SBIO Omega Ratio Rank: 63
SBIO Calmar Ratio Rank: 90
SBIO Martin Ratio Rank: 82

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SBIO vs. XLVI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ALPS Medical Breakthroughs ETF (SBIO) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	SBIO	XLVI	Difference
Sharpe ratio: Return per unit of total volatility	2.35	—	—
Sortino ratio: Return per unit of downside risk	3.22	—	—
Omega ratio: Gain probability vs. loss probability	1.38	—	—
Calmar ratio: Return relative to maximum drawdown	5.47	—	—
Martin ratio: Return relative to average drawdown	16.23	—	—
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

Sharpe Ratios by Period

	SBIO	XLVI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.35	—	—
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.09	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.24	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.22	1.54	-1.32

Drawdowns

SBIO vs. XLVI - Drawdown Comparison

The maximum SBIO drawdown since its inception was -63.06%, which is greater than XLVI's maximum drawdown of -8.14%. Use the drawdown chart below to compare losses from any high point for SBIO and XLVI.

Drawdown Indicators

	SBIO	XLVI	Difference
Max Drawdown Largest peak-to-trough decline	-63.06%	-8.14%	-54.92%
Max Drawdown (1Y) Largest decline over 1 year	-12.66%	—	—
Max Drawdown (3Y) Largest decline over 3 years	-42.44%	—	—
Max Drawdown (5Y) Largest decline over 5 years	-53.10%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-63.06%	—	—
Current Drawdown Current decline from peak	-14.84%	-2.08%	-12.76%
Average Drawdown Average peak-to-trough decline	-28.44%	-1.95%	-26.49%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.26%	—	—

Volatility

Volatility by Period

	SBIO	XLVI	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.85%	—	—
Volatility (6M) Calculated over the trailing 6-month period	22.76%	—	—
Volatility (1Y) Calculated over the trailing 1-year period	29.40%	11.12%	+18.28%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	33.57%	11.12%	+22.45%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	33.18%	11.12%	+22.06%

SBIO vs. XLVI - Expense Ratio Comparison

SBIO has a 0.50% expense ratio, which is higher than XLVI's 0.35% expense ratio.

Dividends

SBIO vs. XLVI - Dividend Comparison

SBIO has not paid dividends to shareholders, while XLVI's dividend yield for the trailing twelve months is around 11.30%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	11.30%	5.73%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both SBIO and XLVI in my portfolio?

SBIO and XLVI have a correlation of 0.45, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, SBIO or XLVI?

On fees, XLVI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, SBIO or XLVI?

XLVI is cheaper with a 0.35% expense ratio, compared with 0.50% for SBIO.

Which ETF pays a higher dividend yield, SBIO or XLVI?

XLVI has the higher dividend yield at 11.30%, compared with 0.00% for SBIO.

What is the main difference between SBIO and XLVI?

SBIO is categorized as Health & Biotech Equities, while XLVI is Derivative Income. They also come from different issuers: SS&C and State Street. Their fees differ too: 0.50% for SBIO and 0.35% for XLVI.