SBIO vs. GERM

Last updated Jun 3, 2026

SBIO (ALPS Medical Breakthroughs ETF) and GERM (Amplify Treatments, Testing and Advancements ETF) are both Health & Biotech Equities funds - SBIO tracks the S-Network Medical Breakthroughs Index while GERM tracks the Prime Treatments, Testing and Advancements Index. Both are passively managed. Over the past year, SBIO returned 67.29% vs 0.00% for GERM. SBIO charges 0.50%/yr vs 0.68%/yr for GERM.

Performance

SBIO vs. GERM - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ALPS Medical Breakthroughs ETF (SBIO) and Amplify Treatments, Testing and Advancements ETF (GERM). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

SBIO

• 1D: -4.73%
• 1M: -6.02%
• YTD: -1.78%
• 6M: 5.47%
• 1Y: 67.29%
• 3Y*: 17.25%
• 5Y*: 2.56%
• 10Y*: 7.86%

GERM

• 1D: 0.00%
• 1M: 0.00%
• YTD: 0.00%
• 6M: 0.00%
• 1Y: 0.00%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

SBIO vs. GERM - Yearly Performance Comparison

	2026 (YTD)	2025	2024
SBIO ALPS Medical Breakthroughs ETF	-1.78%	55.07%	-5.18%
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%

SBIO vs. GERM - Sectors Allocation Comparison

Sectors	SBIO	GERM
Healthcare	100.0%	99.3%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-
Financial Services	-0.0%	0.4%

Return for Risk

SBIO vs. GERM — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SBIO

SBIO Risk / Return Rank: 74
SBIO Sharpe Ratio Rank: 69
SBIO Sortino Ratio Rank: 68
SBIO Omega Ratio Rank: 60
SBIO Calmar Ratio Rank: 90
SBIO Martin Ratio Rank: 84

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SBIO vs. GERM - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ALPS Medical Breakthroughs ETF (SBIO) and Amplify Treatments, Testing and Advancements ETF (GERM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	SBIO	GERM	Difference
Sharpe ratio Return per unit of total volatility	2.30	—	—
Sortino ratio Return per unit of downside risk	3.17	—	—
Omega ratio Gain probability vs. loss probability	1.37	—	—
Calmar ratio Return relative to maximum drawdown	5.74	—	—
Martin ratio Return relative to average drawdown	17.50	—	—
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

Sharpe Ratios by Period

	SBIO	GERM	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.30	—	—
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.08	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.24	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.21	—	—

Drawdowns

SBIO vs. GERM - Drawdown Comparison

The maximum SBIO drawdown since its inception was -63.06%, which is greater than GERM's maximum drawdown of 0.00%. Use the drawdown chart below to compare losses from any high point for SBIO and GERM.

Drawdown Indicators

	SBIO	GERM	Difference
Max Drawdown Largest peak-to-trough decline	-63.06%	0.00%	-63.06%
Max Drawdown (1Y) Largest decline over 1 year	-12.66%	0.00%	-12.66%
Max Drawdown (3Y) Largest decline over 3 years	-42.44%	—	—
Max Drawdown (5Y) Largest decline over 5 years	-53.10%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-63.06%	—	—
Current Drawdown Current decline from peak	-17.95%	0.00%	-17.95%
Average Drawdown Average peak-to-trough decline	-28.45%	0.00%	-28.45%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.15%	0.00%	+4.15%

Volatility

SBIO vs. GERM - Volatility Comparison

ALPS Medical Breakthroughs ETF (SBIO) has a higher volatility of 9.94% compared to Amplify Treatments, Testing and Advancements ETF (GERM) at 0.00%. This indicates that SBIO's price experiences larger fluctuations and is considered to be riskier than GERM based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SBIO	GERM	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.94%	0.00%	+9.94%
Volatility (6M) Calculated over the trailing 6-month period	22.86%	0.00%	+22.86%
Volatility (1Y) Calculated over the trailing 1-year period	29.55%	0.00%	+29.55%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	33.55%	0.00%	+33.55%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	33.18%	0.00%	+33.18%

SBIO vs. GERM - Expense Ratio Comparison

SBIO has a 0.50% expense ratio, which is lower than GERM's 0.68% expense ratio.

Dividends

SBIO vs. GERM - Dividend Comparison

Neither SBIO nor GERM has paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%

Frequently Asked Questions

Which is riskier, SBIO or GERM?

SBIO has higher volatility (9.94%) compared to GERM (0.00%). In terms of maximum drawdown, SBIO dropped -63.06% vs GERM's 0.00%.

Which ETF is better, SBIO or GERM?

On 1-year performance, SBIO leads with 67.29% vs 0.00% for GERM. On fees, SBIO is cheaper at 0.50% per year. On volatility, GERM has been the lower-risk option at 0.00%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, SBIO or GERM?

Over the 1-year period, SBIO has performed better with a 67.29% return vs 0.00%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, SBIO or GERM?

SBIO is cheaper with a 0.50% expense ratio, compared with 0.68% for GERM.

Which ETF pays a higher dividend yield, SBIO or GERM?

SBIO and GERM have nearly identical dividend yields, around 0.00%.

What is the main difference between SBIO and GERM?

SBIO tracks S-Network Medical Breakthroughs Index, while GERM tracks Prime Treatments, Testing and Advancements Index. They also come from different issuers: SS&C and Amplify. Their fees differ too: 0.50% for SBIO and 0.68% for GERM.