iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with IDNA. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to IDNA
IDNA charges 0.47% annually. There are 23 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 42.10B | Dec 1998 | IDNA vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | IDNA vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 20.40B | Jan 2004 | IDNA vs VHT | |
| VanEck Healthcare TruSector ETF | 0.10% | 850.50K | Apr 2026 | IDNA vs TRUH | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 933.15M | Nov 2025 | IDNA vs PBPH |
Best Risk-Adjusted Alternatives to IDNA
IDNA has a PortfoliosLab risk / return rank of 88. There are 15 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| iShares U.S. Pharmaceuticals ETF | 96 | 1.65B | May 2006 | IDNA vs IHE | |
| First Trust Nasdaq Pharmaceuticals ETF | 96 | 911.09M | Sep 2016 | IDNA vs FTXH | |
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 47.80M | Dec 2014 | IDNA vs BBC | |
| Invesco Dynamic Pharmaceuticals ETF | 95 | 472.10M | Jun 2005 | IDNA vs PJP | |
| ALPS Medical Breakthroughs ETF | 95 | 201.57M | Dec 2014 | IDNA vs SBIO |
Top Performing IDNA Alternatives (YTD)
IDNA is at 23.97% YTD. There are 6 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 36.87%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 36.87% | 48.53M | Sep 2021 | IDNA vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 33.10% | 1.73B | Oct 2014 | IDNA vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 28.78% | 7.27M | Dec 2025 | IDNA vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 26.39% | 47.80M | Dec 2014 | IDNA vs BBC | |
| F/m Emerald Life Sciences Innovation ETF | 24.40% | 74.65M | Oct 2024 | IDNA vs LFSC |
Lowest Volatility Alternatives to IDNA
IDNA has 25.03% 1-year volatility. There are 53 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | IDNA vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | IDNA vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.65% | 10.09M | Jun 2007 | IDNA vs SPAQ | |
| Milliman Healthcare Inflation Plus ETF | 10.97% | 982.35K | Apr 2026 | IDNA vs MHIP | |
| State Street Health Care Select Sector SPDR Premiu... | 11.07% | 21.55M | Jul 2025 | IDNA vs XLVI |
Lowest Drawdown Alternatives to IDNA
IDNA has a 1-year max drawdown of -10.66%. There are 19 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | IDNA vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.20% | 10.09M | Jun 2007 | IDNA vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 911.09M | Sep 2016 | IDNA vs FTXH | |
| State Street Health Care Select Sector SPDR Premiu... | -8.14% | 21.55M | Jul 2025 | IDNA vs XLVI | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 75.06M | Jun 2021 | IDNA vs IBBQ |
Other ETFs from iShares
The 10 most viewed iShares ETFs shown here include SGOV, IBIT, SOXX and span 14 categories. AUM among these funds goes as high as $869B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| iShares 0-3 Month Treasury Bond ETF | Ultrashort Bond | 100 | 2.11% | 99.95B | May 2020 | IDNA vs SGOV | |
| iShares Bitcoin Trust ETF | Cryptocurrency | 1 | -28.22% | 46.52B | Jan 2024 | IDNA vs IBIT | |
| iShares Semiconductor ETF | Semiconductors, Technology Equities | 90 | 67.84% | 44.69B | Jul 2001 | IDNA vs SOXX | |
| iShares Core S&P 500 ETF | S&P 500 | 67 | 10.13% | 869.20B | May 2000 | IDNA vs IVV | |
| iShares Core Dividend Growth ETF | Large Cap Growth Equities, Dividend | 91 | 13.39% | 42.77B | Jun 2014 | IDNA vs DGRO | |
| iShares 20+ Year Treasury Bond ETF | Government Bonds, Long-Term Bond | 9 | -3.49% | 41.54B | Jul 2002 | IDNA vs TLT | |
| iShares Silver Trust | Silver, Precious Metals | 36 | -18.72% | 28.08B | Apr 2006 | IDNA vs SLV | |
| iShares Gold Trust | Gold, Precious Metals | 30 | -6.16% | 59.74B | Jan 2005 | IDNA vs IAU | |
| iShares Russell 2000 ETF | Small Cap Blend Equities | 79 | 18.79% | 80.11B | May 2000 | IDNA vs IWM | |
| iShares MSCI ACWI ETF | Global Equities | 71 | 11.28% | 32.49B | Mar 2008 | IDNA vs ACWI |
Often Compared With IDNA
Investors most often compare IDNA with GNOM, IBB, PBE. These 20 comparison targets span 4 categories, based on PortfoliosLab usage data.
Compare IDNA with Any Fund or Stock
Compare IDNA with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair IDNA with funds that move differently
iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to IDNA.
Explore IDNA Diversifiers