IDNA vs. FXAIX

Last updated Jun 3, 2026

IDNA (iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund) and FXAIX (Fidelity 500 Index Fund) are both funds - IDNA is a Health & Biotech Equities fund tracking the NYSE FactSet Global Genomics and Immuno Biopharma Index, while FXAIX is a S&P 500 fund tracking the S&P 500 Index. Both are passively managed. Over the past 5 years, IDNA returned -8.26%/yr vs 14.17%/yr for FXAIX. A 0.57 correlation means they provide meaningful diversification when combined. IDNA charges 0.47%/yr vs 0.02%/yr for FXAIX.

Performance

IDNA vs. FXAIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) and Fidelity 500 Index Fund (FXAIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IDNA achieves a 9.51% return, which is significantly lower than FXAIX's 11.56% return.

IDNA

• 1D: -2.18%
• 1M: -2.18%
• YTD: 9.51%
• 6M: 10.53%
• 1Y: 41.74%
• 3Y*: 6.48%
• 5Y*: -8.26%
• 10Y*: —

FXAIX

• 1D: 0.27%
• 1M: 5.24%
• YTD: 11.56%
• 6M: 11.94%
• 1Y: 29.57%
• 3Y*: 22.70%
• 5Y*: 14.17%
• 10Y*: 15.65%

*Multi-year figures are annualized to reflect compound growth (CAGR)

IDNA vs. FXAIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund	9.51%	17.26%	-0.72%	-7.63%	-42.28%	-3.98%	54.30%	20.83%
FXAIX Fidelity 500 Index Fund	11.56%	17.84%	25.01%	26.29%	-18.14%	28.71%	18.42%	12.90%

Correlation

The correlation between IDNA and FXAIX is 0.55, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.55
Correlation (3Y) Calculated over the trailing 3-year period	0.54
Correlation (5Y) Calculated over the trailing 5-year period	0.58
Correlation (All Time) Calculated using the full available price history since Jun 14, 2019	0.57

The correlation between IDNA and FXAIX has been stable across timeframes, ranging from 0.54 to 0.58 - a consistent structural relationship.

Return for Risk

IDNA vs. FXAIX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IDNA

IDNA Risk / Return Rank: 57
IDNA Sharpe Ratio Rank: 49
IDNA Sortino Ratio Rank: 50
IDNA Omega Ratio Rank: 43
IDNA Calmar Ratio Rank: 79
IDNA Martin Ratio Rank: 64

FXAIX

FXAIX Risk / Return Rank: 75
FXAIX Sharpe Ratio Rank: 77
FXAIX Sortino Ratio Rank: 69
FXAIX Omega Ratio Rank: 69
FXAIX Calmar Ratio Rank: 74
FXAIX Martin Ratio Rank: 84

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IDNA vs. FXAIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) and Fidelity 500 Index Fund (FXAIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IDNA	FXAIX	Difference
Sharpe ratio Return per unit of total volatility	1.71	2.55	-0.84
Sortino ratio Return per unit of downside risk	2.48	3.46	-0.98
Omega ratio Gain probability vs. loss probability	1.28	1.46	-0.18
Calmar ratio Return relative to maximum drawdown	4.09	3.39	+0.71
Martin ratio Return relative to average drawdown	11.79	15.86	-4.07
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IDNA vs. FXAIX - Sharpe Ratio Comparison

The current IDNA Sharpe Ratio is 1.71, which is lower than the FXAIX Sharpe Ratio of 2.55. The chart below compares the historical Sharpe Ratios of IDNA and FXAIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IDNA	FXAIX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.71	2.55	-0.84
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.29	0.84	-1.13
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.87	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.10	0.82	-0.73

Drawdowns

IDNA vs. FXAIX - Drawdown Comparison

The maximum IDNA drawdown since its inception was -68.26%, which is greater than FXAIX's maximum drawdown of -33.79%. Use the drawdown chart below to compare losses from any high point for IDNA and FXAIX.

Drawdown Indicators

	IDNA	FXAIX	Difference
Max Drawdown Largest peak-to-trough decline	-68.26%	-33.79%	-34.47%
Max Drawdown (1Y) Largest decline over 1 year	-10.66%	-8.89%	-1.77%
Max Drawdown (3Y) Largest decline over 3 years	-29.73%	-18.76%	-10.97%
Max Drawdown (5Y) Largest decline over 5 years	-68.26%	-24.50%	-43.76%
Max Drawdown (10Y) Largest decline over 10 years	—	-33.79%	—
Current Drawdown Current decline from peak	-46.01%	0.00%	-46.01%
Average Drawdown Average peak-to-trough decline	-36.24%	-3.79%	-32.45%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.70%	1.90%	+1.80%

Volatility

IDNA vs. FXAIX - Volatility Comparison

iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) has a higher volatility of 7.24% compared to Fidelity 500 Index Fund (FXAIX) at 2.82%. This indicates that IDNA's price experiences larger fluctuations and is considered to be riskier than FXAIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IDNA	FXAIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.24%	2.82%	+4.42%
Volatility (6M) Calculated over the trailing 6-month period	18.21%	8.99%	+9.22%
Volatility (1Y) Calculated over the trailing 1-year period	24.51%	11.88%	+12.63%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	28.42%	16.91%	+11.51%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	29.53%	18.07%	+11.46%

IDNA vs. FXAIX - Expense Ratio Comparison

IDNA has a 0.47% expense ratio, which is higher than FXAIX's 0.02% expense ratio.

Dividends

IDNA vs. FXAIX - Dividend Comparison

IDNA's dividend yield for the trailing twelve months is around 1.08%, more than FXAIX's 1.03% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
FXAIX Fidelity 500 Index Fund	1.03%	1.11%	1.25%	1.45%	1.69%	1.22%	1.60%	2.06%	2.72%	1.97%	2.52%	2.83%
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund	1.08%	1.18%	0.98%	1.04%	0.54%	0.70%	0.26%	0.80%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both IDNA and FXAIX in my portfolio?

IDNA and FXAIX have a correlation of 0.55, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IDNA or FXAIX?

IDNA has higher volatility (7.24%) compared to FXAIX (2.82%). In terms of maximum drawdown, IDNA dropped -68.26% vs FXAIX's -33.79%.

Which has better risk-adjusted returns?

FXAIX currently has the higher Sharpe Ratio (2.55 vs 1.71), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.