IDNA vs. FXAIX
IDNA (iShares Genomics Immunology and Healthcare ETF) and FXAIX (Fidelity 500 Index Fund) are both funds - IDNA is a Health & Biotech Equities fund tracking the NYSE FactSet Global Genomics and Immuno Biopharma Index (USD) (Net), while FXAIX is a S&P 500 fund tracking the S&P 500 Index. Both are passively managed. Over the past 5 years, IDNA returned -7.52%/yr vs 12.68%/yr for FXAIX. Their 0.57 correlation means they have sometimes moved together and sometimes differently. IDNA charges 0.47%/yr vs 0.02%/yr for FXAIX.
Performance
IDNA vs. FXAIX - Performance Comparison
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Returns By Period
In the year-to-date period, IDNA achieves a 23.97% return, which is significantly higher than FXAIX's 9.35% return.
IDNA
- 1D
- -1.40%
- 1M
- -7.39%
- 6M
- 13.88%
- YTD
- 23.97%
- 1Y
- 54.41%
- 3Y*
- 12.75%
- 5Y*
- -7.52%
- 10Y*
- —
- ALL TIME*
- 4.74%
FXAIX
- 1D
- 1.66%
- 1M
- -0.56%
- 6M
- 7.79%
- YTD
- 9.35%
- 1Y
- 20.63%
- 3Y*
- 19.03%
- 5Y*
- 12.68%
- 10Y*
- 15.00%
- ALL TIME*
- 13.89%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $0.00 | $0.00 | $0.00 | |
| $842.73K | $1.44M | $1.52M |
IDNA vs. FXAIX - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | |
|---|---|---|---|---|---|---|---|---|
IDNA iShares Genomics Immunology and Healthcare ETF | 23.97% | 17.26% | -0.72% | -7.63% | -42.28% | -3.98% | 54.30% | 22.10% |
FXAIX Fidelity 500 Index Fund | 9.35% | 17.84% | 25.01% | 26.29% | -18.14% | 28.71% | 18.42% | 13.39% |
Correlation
The correlation between IDNA and FXAIX is 0.51, which is moderate. They have sometimes moved together and sometimes differently, sharing some price drivers without tracking each other closely.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.51 |
Correlation (3Y) Balances recent behavior with more history. | 0.53 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.58 |
Correlation (All Time) Calculated using the full available price history since Jun 13, 2019 | 0.57 |
The correlation between IDNA and FXAIX has been stable across timeframes, ranging from 0.51 to 0.58 - a consistent structural relationship.
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Return for Risk
IDNA vs. FXAIX — Risk / Return Rank
IDNA
FXAIX
IDNA vs. FXAIX - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for iShares Genomics Immunology and Healthcare ETF (IDNA) and Fidelity 500 Index Fund (FXAIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| IDNA | FXAIX | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.74 | ||
| Sortino ratioReturn per unit of downside risk | +1.01 | ||
| Omega ratioGain probability vs. loss probability | 1.34 | 1.26 | +0.08 |
| Calmar ratioReturn relative to maximum drawdown | 5.06 | 2.06 | +2.99 |
| Martin ratioReturn relative to average drawdown | 13.37 | 8.86 | +4.51 |
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Drawdowns
IDNA vs. FXAIX - Drawdown Comparison
The maximum IDNA drawdown since its inception was -68.26%, which is greater than FXAIX's maximum drawdown of -33.79%. Use the drawdown chart below to compare losses from any high point for IDNA and FXAIX.
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Drawdown Indicators
| IDNA | FXAIX | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -68.26% | -33.79% | -34.47% |
Max Drawdown (1Y)Largest decline over 1 year | -10.66% | -8.89% | -1.77% |
Max Drawdown (3Y)Largest decline over 3 years | -29.46% | -18.76% | -10.70% |
Max Drawdown (5Y)Largest decline over 5 years | -68.26% | -24.50% | -43.76% |
Max Drawdown (10Y)Largest decline over 10 years | — | -33.79% | — |
Current DrawdownCurrent decline from peak | -38.88% | -2.11% | -36.77% |
Average DrawdownAverage peak-to-trough decline | -36.30% | -3.77% | -32.53% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 4.03% | 2.07% | +1.96% |
Volatility
IDNA vs. FXAIX - Volatility Comparison
iShares Genomics Immunology and Healthcare ETF (IDNA) has a higher volatility of 7.04% compared to Fidelity 500 Index Fund (FXAIX) at 3.44%. This indicates that IDNA's price experiences larger fluctuations and is considered to be riskier than FXAIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| IDNA | FXAIX | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 7.04% | 3.44% | +3.60% |
Volatility (6M)Calculated over the trailing 6-month period | 18.24% | 10.09% | +8.15% |
Volatility (1Y)Calculated over the trailing 1-year period | 25.03% | 12.86% | +12.17% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 28.50% | 17.03% | +11.47% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 29.44% | 18.07% | +11.37% |
IDNA vs. FXAIX - Expense Ratio Comparison
IDNA has a 0.47% expense ratio, which is higher than FXAIX's 0.02% expense ratio.
Dividends
IDNA vs. FXAIX - Dividend Comparison
IDNA's dividend yield for the trailing twelve months is around 0.87%, less than FXAIX's 1.07% yield.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
FXAIX Fidelity 500 Index Fund | 1.07% | 1.11% | 1.25% | 1.45% | 1.69% | 1.22% | 1.60% | 2.06% | 2.72% | 1.97% | 2.52% | 2.83% |
IDNA iShares Genomics Immunology and Healthcare ETF | 0.87% | 1.18% | 0.98% | 1.04% | 0.54% | 0.70% | 0.26% | 0.80% | 0.00% | 0.00% | 0.00% | 0.00% |
Frequently Asked Questions
IDNA and FXAIX have a correlation of 0.51, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
IDNA has higher volatility (7.04%) compared to FXAIX (3.44%). In terms of maximum drawdown, IDNA dropped -68.26% vs FXAIX's -33.79%.
IDNA currently has the higher Sharpe Ratio (2.17 vs 1.43), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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