IDNA vs. FTXH

Last updated Jun 3, 2026

IDNA (iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund) and FTXH (First Trust Nasdaq Pharmaceuticals ETF) are both Health & Biotech Equities funds - IDNA tracks the NYSE FactSet Global Genomics and Immuno Biopharma Index while FTXH tracks the Nasdaq U.S. Smart Pharmaceuticals Index. Both are passively managed. Over the past 5 years, IDNA returned -8.26%/yr vs 7.39%/yr for FTXH. A 0.64 correlation means they provide meaningful diversification when combined. IDNA charges 0.47%/yr vs 0.60%/yr for FTXH.

Performance

IDNA vs. FTXH - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) and First Trust Nasdaq Pharmaceuticals ETF (FTXH). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IDNA achieves a 9.51% return, which is significantly higher than FTXH's 3.25% return.

IDNA

• 1D: -2.18%
• 1M: -2.18%
• YTD: 9.51%
• 6M: 10.53%
• 1Y: 41.74%
• 3Y*: 6.48%
• 5Y*: -8.26%
• 10Y*: —

FTXH

• 1D: -1.29%
• 1M: 0.42%
• YTD: 3.25%
• 6M: 5.49%
• 1Y: 34.34%
• 3Y*: 10.86%
• 5Y*: 7.39%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IDNA vs. FTXH - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund	9.51%	17.26%	-0.72%	-7.63%	-42.28%	-3.98%	54.30%	20.83%
FTXH First Trust Nasdaq Pharmaceuticals ETF	3.25%	24.15%	2.98%	-1.41%	2.55%	6.14%	11.73%	13.77%

Correlation

The correlation between IDNA and FTXH is 0.74, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.74
Correlation (3Y) Calculated over the trailing 3-year period	0.71
Correlation (5Y) Calculated over the trailing 5-year period	0.64
Correlation (All Time) Calculated using the full available price history since Jun 14, 2019	0.64

The correlation between IDNA and FTXH shifts across timeframes, from 0.64 (all time) to 0.74 (1 year), reflecting how their relationship changes across market environments.

IDNA vs. FTXH - Sectors Allocation Comparison

Sectors	IDNA	FTXH
Healthcare	97.8%	100.0%
Industrials	0.4%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

IDNA vs. FTXH — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IDNA

IDNA Risk / Return Rank: 57
IDNA Sharpe Ratio Rank: 49
IDNA Sortino Ratio Rank: 50
IDNA Omega Ratio Rank: 43
IDNA Calmar Ratio Rank: 79
IDNA Martin Ratio Rank: 64

FTXH

FTXH Risk / Return Rank: 67
FTXH Sharpe Ratio Rank: 60
FTXH Sortino Ratio Rank: 64
FTXH Omega Ratio Rank: 56
FTXH Calmar Ratio Rank: 84
FTXH Martin Ratio Rank: 71

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IDNA vs. FTXH - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) and First Trust Nasdaq Pharmaceuticals ETF (FTXH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IDNA	FTXH	Difference
Sharpe ratio Return per unit of total volatility	1.71	2.04	-0.33
Sortino ratio Return per unit of downside risk	2.48	3.02	-0.54
Omega ratio Gain probability vs. loss probability	1.28	1.35	-0.07
Calmar ratio Return relative to maximum drawdown	4.09	4.68	-0.58
Martin ratio Return relative to average drawdown	11.79	13.56	-1.77
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IDNA vs. FTXH - Sharpe Ratio Comparison

The current IDNA Sharpe Ratio is 1.71, which is comparable to the FTXH Sharpe Ratio of 2.04. The chart below compares the historical Sharpe Ratios of IDNA and FTXH, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IDNA	FTXH	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.71	2.04	-0.33
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.29	0.46	-0.75
Sharpe Ratio (All Time) Calculated using the full available price history	0.10	0.37	-0.27

Drawdowns

IDNA vs. FTXH - Drawdown Comparison

The maximum IDNA drawdown since its inception was -68.26%, which is greater than FTXH's maximum drawdown of -32.11%. Use the drawdown chart below to compare losses from any high point for IDNA and FTXH.

Drawdown Indicators

	IDNA	FTXH	Difference
Max Drawdown Largest peak-to-trough decline	-68.26%	-32.11%	-36.15%
Max Drawdown (1Y) Largest decline over 1 year	-10.66%	-7.47%	-3.19%
Max Drawdown (3Y) Largest decline over 3 years	-29.73%	-19.51%	-10.22%
Max Drawdown (5Y) Largest decline over 5 years	-68.26%	-19.51%	-48.75%
Current Drawdown Current decline from peak	-46.01%	-4.49%	-41.52%
Average Drawdown Average peak-to-trough decline	-36.24%	-5.84%	-30.40%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.70%	2.58%	+1.12%

Volatility

IDNA vs. FTXH - Volatility Comparison

iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) has a higher volatility of 7.24% compared to First Trust Nasdaq Pharmaceuticals ETF (FTXH) at 4.56%. This indicates that IDNA's price experiences larger fluctuations and is considered to be riskier than FTXH based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IDNA	FTXH	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.24%	4.56%	+2.68%
Volatility (6M) Calculated over the trailing 6-month period	18.21%	11.76%	+6.45%
Volatility (1Y) Calculated over the trailing 1-year period	24.51%	16.91%	+7.60%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	28.42%	16.29%	+12.13%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	29.53%	18.41%	+11.12%

IDNA vs. FTXH - Expense Ratio Comparison

IDNA has a 0.47% expense ratio, which is lower than FTXH's 0.60% expense ratio.

Dividends

IDNA vs. FTXH - Dividend Comparison

IDNA's dividend yield for the trailing twelve months is around 1.08%, less than FTXH's 1.24% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016
FTXH First Trust Nasdaq Pharmaceuticals ETF	1.24%	1.41%	1.66%	1.55%	1.11%	1.03%	0.82%	0.67%	0.91%	2.18%	0.19%
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund	1.08%	1.18%	0.98%	1.04%	0.54%	0.70%	0.26%	0.80%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both IDNA and FTXH in my portfolio?

IDNA and FTXH have a correlation of 0.74, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IDNA or FTXH?

IDNA has higher volatility (7.24%) compared to FTXH (4.56%). In terms of maximum drawdown, IDNA dropped -68.26% vs FTXH's -32.11%.

Which ETF is better, IDNA or FTXH?

On 5-year performance, FTXH leads with 7.39% vs -8.26% for IDNA. On fees, IDNA is cheaper at 0.47% per year. On volatility, FTXH has been the lower-risk option at 4.56%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, IDNA or FTXH?

Over the 5-year period, FTXH has performed better with a 7.39% return vs -8.26%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, IDNA or FTXH?

IDNA is cheaper with a 0.47% expense ratio, compared with 0.60% for FTXH.

Which ETF pays a higher dividend yield, IDNA or FTXH?

FTXH has the higher dividend yield at 1.24%, compared with 1.08% for IDNA.

What is the main difference between IDNA and FTXH?

IDNA tracks NYSE FactSet Global Genomics and Immuno Biopharma Index, while FTXH tracks Nasdaq U.S. Smart Pharmaceuticals Index. They also come from different issuers: iShares and First Trust. Their fees differ too: 0.47% for IDNA and 0.60% for FTXH.

Which has better risk-adjusted returns?

FTXH currently has the higher Sharpe Ratio (2.04 vs 1.71), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.