IDNA vs. WDNA

Last updated Jun 23, 2026

IDNA (iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund) and WDNA (WisdomTree BioRevolution Fund) are both Health & Biotech Equities funds - IDNA tracks the NYSE FactSet Global Genomics and Immuno Biopharma Index while WDNA tracks the WisdomTree BioRevolution Index. Both are passively managed. Over the past 5 years, IDNA returned -8.07%/yr vs -4.94%/yr for WDNA. Their correlation of 0.90 suggests significant overlap in exposure. IDNA charges 0.47%/yr vs 0.45%/yr for WDNA.

Performance

IDNA vs. WDNA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) and WisdomTree BioRevolution Fund (WDNA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IDNA achieves a 17.72% return, which is significantly higher than WDNA's 12.77% return.

IDNA

• 1D: 0.46%
• 1M: 4.69%
• YTD: 17.72%
• 6M: 14.99%
• 1Y: 51.77%
• 3Y*: 10.60%
• 5Y*: -8.07%
• 10Y*: —

WDNA

• 1D: 0.90%
• 1M: 8.40%
• YTD: 12.77%
• 6M: 10.12%
• 1Y: 49.11%
• 3Y*: 5.29%
• 5Y*: -4.94%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IDNA vs. WDNA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund	17.72%	17.26%	-0.72%	-7.63%	-42.28%	-5.50%
WDNA WisdomTree BioRevolution Fund	12.77%	22.68%	-14.18%	-2.07%	-26.29%	-4.92%

Correlation

The correlation between IDNA and WDNA is 0.89, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.89
Correlation (3Y) Calculated over the trailing 3-year period	0.89
Correlation (5Y) Calculated over the trailing 5-year period	0.91
Correlation (All Time) Calculated using the full available price history since Jun 3, 2021	0.90

The correlation between IDNA and WDNA has been stable across timeframes, ranging from 0.89 to 0.91 - a consistent structural relationship.

IDNA vs. WDNA - Sectors Allocation Comparison

Sectors	IDNA	WDNA
Healthcare	99.3%	85.0%
Industrials	0.3%	-
Basic Materials	-	6.5%
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	3.0%
Energy	-	1.1%
Financial Services	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

IDNA vs. WDNA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IDNA

IDNA Risk / Return Rank: 70
IDNA Sharpe Ratio Rank: 66
IDNA Sortino Ratio Rank: 66
IDNA Omega Ratio Rank: 55
IDNA Calmar Ratio Rank: 88
IDNA Martin Ratio Rank: 74

WDNA

WDNA Risk / Return Rank: 61
WDNA Sharpe Ratio Rank: 58
WDNA Sortino Ratio Rank: 60
WDNA Omega Ratio Rank: 51
WDNA Calmar Ratio Rank: 82
WDNA Martin Ratio Rank: 56

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IDNA vs. WDNA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) and WisdomTree BioRevolution Fund (WDNA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	IDNA	WDNA	Difference
Sharpe ratio: Return per unit of total volatility	2.09	1.91	+0.18
Sortino ratio: Return per unit of downside risk	2.92	2.73	+0.18
Omega ratio: Gain probability vs. loss probability	1.33	1.31	+0.02
Calmar ratio: Return relative to maximum drawdown	4.88	4.22	+0.66
Martin ratio: Return relative to average drawdown	13.60	9.45	+4.15

IDNA vs. WDNA - Sharpe Ratio Comparison

The current IDNA Sharpe Ratio is 2.09, which is comparable to the WDNA Sharpe Ratio of 1.91. The chart below compares the historical Sharpe Ratios of IDNA and WDNA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

IDNA vs. WDNA - Drawdown Comparison

The maximum IDNA drawdown since its inception was -68.26%, which is greater than WDNA's maximum drawdown of -58.87%. Use the drawdown chart below to compare losses from any high point for IDNA and WDNA.

Drawdown Indicators

	IDNA	WDNA	Difference
Max Drawdown Largest peak-to-trough decline	-68.26%	-58.87%	-9.39%
Max Drawdown (1Y) Largest decline over 1 year	-10.66%	-11.70%	+1.04%
Max Drawdown (3Y) Largest decline over 3 years	-29.46%	-38.25%	+8.79%
Max Drawdown (5Y) Largest decline over 5 years	-68.26%	-58.87%	-9.39%
Current Drawdown Current decline from peak	-41.96%	-27.41%	-14.55%
Average Drawdown Average peak-to-trough decline	-36.28%	-35.57%	-0.71%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.82%	5.21%	-1.39%

Volatility

IDNA vs. WDNA - Volatility Comparison

iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) and WisdomTree BioRevolution Fund (WDNA) have volatilities of 7.25% and 7.42%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IDNA	WDNA	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.25%	7.42%	-0.17%
Volatility (6M) Calculated over the trailing 6-month period	18.40%	16.98%	+1.42%
Volatility (1Y) Calculated over the trailing 1-year period	24.97%	25.95%	-0.98%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	28.46%	25.14%	+3.32%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	29.52%	25.07%	+4.45%

IDNA vs. WDNA - Expense Ratio Comparison

IDNA has a 0.47% expense ratio, which is higher than WDNA's 0.45% expense ratio.

Dividends

IDNA vs. WDNA - Dividend Comparison

IDNA's dividend yield for the trailing twelve months is around 0.91%, less than WDNA's 4.05% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund	0.91%	1.18%	0.98%	1.04%	0.54%	0.70%	0.26%	0.80%
WDNA WisdomTree BioRevolution Fund	4.05%	4.57%	0.75%	0.80%	0.38%	0.10%	0.00%	0.00%

Frequently Asked Questions

Can I hold both IDNA and WDNA in my portfolio?

IDNA and WDNA have a correlation of 0.89, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IDNA or WDNA?

WDNA has higher volatility (7.42%) compared to IDNA (7.25%). In terms of maximum drawdown, IDNA dropped -68.26% vs WDNA's -58.87%.

Which ETF is better, IDNA or WDNA?

On 5-year performance, WDNA leads with -4.94% vs -8.07% for IDNA. On fees, WDNA is cheaper at 0.45% per year. On volatility, IDNA has been the lower-risk option at 7.25%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, IDNA or WDNA?

Over the 5-year period, WDNA has performed better with a -4.94% return vs -8.07%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, IDNA or WDNA?

WDNA is cheaper with a 0.45% expense ratio, compared with 0.47% for IDNA.

Which ETF pays a higher dividend yield, IDNA or WDNA?

WDNA has the higher dividend yield at 4.05%, compared with 0.91% for IDNA.

What is the main difference between IDNA and WDNA?

IDNA tracks NYSE FactSet Global Genomics and Immuno Biopharma Index, while WDNA tracks WisdomTree BioRevolution Index. They also come from different issuers: iShares and WisdomTree. Their fees differ too: 0.47% for IDNA and 0.45% for WDNA.

Which has better risk-adjusted returns?

IDNA currently has the higher Sharpe Ratio (2.09 vs 1.91), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.