IDNA vs. XLVI

Last updated Jun 3, 2026

IDNA (iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund) and XLVI (State Street Health Care Select Sector SPDR Premium Income ETF) are both exchange-traded funds - IDNA is a Health & Biotech Equities fund tracking the NYSE FactSet Global Genomics and Immuno Biopharma Index, while XLVI is a Derivative Income fund actively managed by State Street. IDNA is passively managed, while XLVI is actively managed. A 0.57 correlation means they provide meaningful diversification when combined. IDNA charges 0.47%/yr vs 0.35%/yr for XLVI.

Performance

IDNA vs. XLVI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IDNA achieves a 9.51% return, which is significantly higher than XLVI's -1.33% return.

IDNA

• 1D: -2.18%
• 1M: -2.18%
• YTD: 9.51%
• 6M: 10.53%
• 1Y: 41.74%
• 3Y*: 6.48%
• 5Y*: -8.26%
• 10Y*: —

XLVI

• 1D: -0.73%
• 1M: 1.42%
• YTD: -1.33%
• 6M: 0.46%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IDNA vs. XLVI - Yearly Performance Comparison

	2026 (YTD)	2025
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund	9.51%	21.07%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	-1.33%	12.79%

Correlation

The correlation between IDNA and XLVI is 0.57, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (All Time) Calculated using the full available price history since Jul 31, 2025	0.57

IDNA vs. XLVI - Sectors Allocation Comparison

Sectors	IDNA	XLVI
Healthcare	97.8%	-
Industrials	0.4%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	100.6%
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

IDNA vs. XLVI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IDNA

IDNA Risk / Return Rank: 57
IDNA Sharpe Ratio Rank: 49
IDNA Sortino Ratio Rank: 50
IDNA Omega Ratio Rank: 43
IDNA Calmar Ratio Rank: 79
IDNA Martin Ratio Rank: 64

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IDNA vs. XLVI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IDNA	XLVI	Difference
Sharpe ratio Return per unit of total volatility	1.71	—	—
Sortino ratio Return per unit of downside risk	2.48	—	—
Omega ratio Gain probability vs. loss probability	1.28	—	—
Calmar ratio Return relative to maximum drawdown	4.09	—	—
Martin ratio Return relative to average drawdown	11.79	—	—
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

Sharpe Ratios by Period

	IDNA	XLVI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.71	—	—
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.29	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.10	1.25	-1.15

Drawdowns

IDNA vs. XLVI - Drawdown Comparison

The maximum IDNA drawdown since its inception was -68.26%, which is greater than XLVI's maximum drawdown of -8.14%. Use the drawdown chart below to compare losses from any high point for IDNA and XLVI.

Drawdown Indicators

	IDNA	XLVI	Difference
Max Drawdown Largest peak-to-trough decline	-68.26%	-8.14%	-60.12%
Max Drawdown (1Y) Largest decline over 1 year	-10.66%	—	—
Max Drawdown (3Y) Largest decline over 3 years	-29.73%	—	—
Max Drawdown (5Y) Largest decline over 5 years	-68.26%	—	—
Current Drawdown Current decline from peak	-46.01%	-4.66%	-41.35%
Average Drawdown Average peak-to-trough decline	-36.24%	-1.94%	-34.30%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.70%	—	—

Volatility

Volatility by Period

	IDNA	XLVI	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.24%	—	—
Volatility (6M) Calculated over the trailing 6-month period	18.21%	—	—
Volatility (1Y) Calculated over the trailing 1-year period	24.51%	10.94%	+13.57%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	28.42%	10.94%	+17.48%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	29.53%	10.94%	+18.59%

IDNA vs. XLVI - Expense Ratio Comparison

IDNA has a 0.47% expense ratio, which is higher than XLVI's 0.35% expense ratio.

Dividends

IDNA vs. XLVI - Dividend Comparison

IDNA's dividend yield for the trailing twelve months is around 1.08%, less than XLVI's 11.61% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund	1.08%	1.18%	0.98%	1.04%	0.54%	0.70%	0.26%	0.80%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	11.61%	5.73%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both IDNA and XLVI in my portfolio?

IDNA and XLVI have a correlation of 0.57, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, IDNA or XLVI?

On fees, XLVI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, IDNA or XLVI?

XLVI is cheaper with a 0.35% expense ratio, compared with 0.47% for IDNA.

Which ETF pays a higher dividend yield, IDNA or XLVI?

XLVI has the higher dividend yield at 11.61%, compared with 1.08% for IDNA.

What is the main difference between IDNA and XLVI?

IDNA is categorized as Health & Biotech Equities, while XLVI is Derivative Income. They also come from different issuers: iShares and State Street. Their fees differ too: 0.47% for IDNA and 0.35% for XLVI.