AdvisorShares Psychedelics ETF (PSIL) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with PSIL. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to PSIL
PSIL charges 1.00% annually. There are 65 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | PSIL vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 42.10B | Dec 1998 | PSIL vs XLV | |
| Vanguard Health Care ETF | 0.09% | 20.40B | Jan 2004 | PSIL vs VHT | |
| VanEck Healthcare TruSector ETF | 0.10% | 850.50K | Apr 2026 | PSIL vs TRUH | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 933.15M | Nov 2025 | PSIL vs PBPH |
Best Risk-Adjusted Alternatives to PSIL
PSIL has a PortfoliosLab risk / return rank of 57. There are 44 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| iShares U.S. Pharmaceuticals ETF | 96 | 1.65B | May 2006 | PSIL vs IHE | |
| First Trust Nasdaq Pharmaceuticals ETF | 96 | 911.09M | Sep 2016 | PSIL vs FTXH | |
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 47.80M | Dec 2014 | PSIL vs BBC | |
| Invesco Dynamic Pharmaceuticals ETF | 95 | 472.10M | Jun 2005 | PSIL vs PJP | |
| ALPS Medical Breakthroughs ETF | 95 | 201.57M | Dec 2014 | PSIL vs SBIO |
Top Performing PSIL Alternatives (YTD)
PSIL is at 36.87% YTD. No ETFs in the Health & Biotech Equities category have higher YTD returns; the top-performing alternatives shown here go as high as 33.10%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 33.10% | 1.73B | Oct 2014 | PSIL vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 28.78% | 7.27M | Dec 2025 | PSIL vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 26.39% | 47.80M | Dec 2014 | PSIL vs BBC | |
| F/m Emerald Life Sciences Innovation ETF | 24.40% | 74.65M | Oct 2024 | PSIL vs LFSC | |
| SPDR S&P Health Care Services ETF | 24.28% | 206.72M | Sep 2011 | PSIL vs XHS |
Lowest Volatility Alternatives to PSIL
PSIL has 40.73% 1-year volatility. There are 62 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | PSIL vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PSIL vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.65% | 10.09M | Jun 2007 | PSIL vs SPAQ | |
| Milliman Healthcare Inflation Plus ETF | 10.97% | 982.35K | Apr 2026 | PSIL vs MHIP | |
| State Street Health Care Select Sector SPDR Premiu... | 11.07% | 21.55M | Jul 2025 | PSIL vs XLVI |
Lowest Drawdown Alternatives to PSIL
PSIL has a 1-year max drawdown of -20.38%. There are 53 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PSIL vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.20% | 10.09M | Jun 2007 | PSIL vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 911.09M | Sep 2016 | PSIL vs FTXH | |
| State Street Health Care Select Sector SPDR Premiu... | -8.14% | 21.55M | Jul 2025 | PSIL vs XLVI | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 75.06M | Jun 2021 | PSIL vs IBBQ |
Other ETFs from AdvisorShares
The 10 most viewed AdvisorShares ETFs shown here include MSOS, AADR, YOLO and span 8 categories. AUM among these funds goes as high as $853M.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| AdvisorShares Pure US Cannabis ETF | Small Cap Blend Equities, Cannabis, Actively Managed | 31 | -10.38% | 852.98M | Sep 2020 | PSIL vs MSOS | |
| AdvisorShares Dorsey Wright ADR ETF | Global Equities | 17 | -3.26% | 38.14M | Jul 2010 | PSIL vs AADR | |
| AdvisorShares Pure Cannabis ETF | Cannabis | 21 | -23.04% | 29.95M | Apr 2019 | PSIL vs YOLO | |
| AdvisorShares Focused Equity ETF | Large Cap Growth Equities | 18 | 3.94% | 130.83M | Sep 2016 | PSIL vs CWS | |
| Advisorshares Msos 2x Daily ETF | Leveraged Equities | 18 | -49.55% | 49.50M | Aug 2022 | PSIL vs MSOX | |
| AdvisorShares Ranger Equity Bear ETF | Inverse Equities | 5 | -5.56% | 56.68M | Jan 2011 | PSIL vs HDGE | |
| AdvisorShares Gerber Kawasaki ETF | Large Cap Growth Equities | 29 | 10.37% | 30.63M | Jul 2021 | PSIL vs GK | |
| AdvisorShares Vice ETF | Consumer Discretionary Equities | 6 | 4.78% | 7.34M | Dec 2017 | PSIL vs VICE | |
| AdvisorShares Q Dynamic Growth ETF | Large Cap Growth Equities | 50 | 6.38% | 30.99M | Dec 2020 | PSIL vs QPX | |
| AdvisorShares Hotel ETF | Consumer Discretionary Equities | 34 | 11.91% | 2.99M | Apr 2021 | PSIL vs BEDZ |
Often Compared With PSIL
Investors most often compare PSIL with IBB, XHE, HTEC. These 20 comparison targets span 1 categories, based on PortfoliosLab usage data.
Compare PSIL with Any Fund or Stock
Compare PSIL with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair PSIL with funds that move differently
AdvisorShares Psychedelics ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to PSIL.
Explore PSIL Diversifiers