ROBO Global Healthcare Technology and Innovation ETF (HTEC) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with HTEC. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to HTEC
HTEC charges 0.68% annually. There are 44 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | HTEC vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | HTEC vs XLV | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | HTEC vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | HTEC vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | HTEC vs GSKH |
Best Risk-Adjusted Alternatives to HTEC
HTEC has a PortfoliosLab risk / return rank of 53. There are 33 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | HTEC vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | HTEC vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | HTEC vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | HTEC vs IHE | |
| iShares Neuroscience and Healthcare ETF | 93 | 5.85M | Aug 2022 | HTEC vs IBRN |
Top Performing HTEC Alternatives (YTD)
HTEC is at 7.64% YTD. There are 31 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 40.11%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 40.11% | 1.31B | Oct 2014 | HTEC vs ARKG | |
| AdvisorShares Psychedelics ETF | 35.29% | 44.37M | Sep 2021 | HTEC vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 34.33% | 6.01M | Dec 2025 | HTEC vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.14% | 57.56M | Dec 2014 | HTEC vs BBC | |
| ALPS Medical Breakthroughs ETF | 27.56% | 213.08M | Dec 2014 | HTEC vs SBIO |
Lowest Volatility Alternatives to HTEC
HTEC has 21.66% 1-year volatility. There are 41 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | HTEC vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | HTEC vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.64% | 10.11M | Jun 2007 | HTEC vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.87% | 16.78M | Jul 2025 | HTEC vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.73% | 982.35K | Apr 2026 | HTEC vs MHIP |
Lowest Drawdown Alternatives to HTEC
HTEC has a 1-year max drawdown of -16.31%. There are 41 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | HTEC vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | HTEC vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | HTEC vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | HTEC vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | HTEC vs IHE |
Other ETFs from Exchange Traded Concepts
The 10 most viewed Exchange Traded Concepts ETFs shown here include NUKZ, ROBO, CEFS and span 11 categories. AUM among these funds goes as high as $2B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Range Nuclear Renaissance ETF | Energy Equities | 21 | 0.76% | 832.38M | Jan 2024 | HTEC vs NUKZ | |
| ROBO Global Robotics & Automation Index ETF | Robotics, Technology Equities | 47 | 16.23% | 1.84B | Oct 2013 | HTEC vs ROBO | |
| Saba Closed-End Funds ETF | Event Driven, Actively Managed | 85 | 13.68% | 332.90M | Mar 2017 | HTEC vs CEFS | |
| High Yield ETF | High Yield Bonds | — | — | 95.91M | Nov 2010 | HTEC vs HYLD | |
| ROBO Global Artificial Intelligence ETF | Technology Equities | 77 | 37.45% | 451.01M | May 2020 | HTEC vs THNQ | |
| Hull Tactical US ETF | Long-Short | 74 | 10.92% | 137.43M | Jun 2015 | HTEC vs HTUS | |
| QRAFT AI-Enhanced U.S. Large Cap Momentum ETF | Momentum, Large Cap Growth Equities | 47 | 21.66% | 33.44M | May 2019 | HTEC vs AMOM | |
| EMQQ The Emerging Markets Internet ETF | Emerging Markets Equities | 4 | -18.29% | 273.19M | Nov 2014 | HTEC vs EMQQ | |
| Nifty India Financials ETF | Financials Equities | — | — | 10.83M | Oct 2020 | HTEC vs INDF | |
| QRAFT AI Enhanced U.S. Large Cap ETF | Large Cap Growth Equities | 63 | 11.94% | 15.70M | May 2019 | HTEC vs QRFT |
Often Compared With HTEC
Investors most often compare HTEC with WTAI, HEAL, MDEV. These 20 comparison targets span 13 categories, based on PortfoliosLab usage data.
Compare HTEC with Any Fund or Stock
Compare HTEC with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair HTEC with funds that move differently
ROBO Global Healthcare Technology and Innovation ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to HTEC.
Explore HTEC Diversifiers