ARWR vs. ALNY

Last updated Jun 4, 2026

ARWR (Arrowhead Pharmaceuticals, Inc.) and ALNY (Alnylam Pharmaceuticals, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, ARWR returned 28.05%/yr vs 15.34%/yr for ALNY. At a 0.29 correlation, their price movements are largely independent.

Performance

ARWR vs. ALNY - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Arrowhead Pharmaceuticals, Inc. (ARWR) and Alnylam Pharmaceuticals, Inc. (ALNY). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ARWR achieves a 9.28% return, which is significantly higher than ALNY's -26.42% return. Over the past 10 years, ARWR has outperformed ALNY with an annualized return of 28.05%, while ALNY has yielded a comparatively lower 15.34% annualized return.

ARWR

• 1D: 2.44%
• 1M: -5.03%
• YTD: 9.28%
• 6M: 11.49%
• 1Y: 336.79%
• 3Y*: 26.25%
• 5Y*: -0.96%
• 10Y*: 28.05%

ALNY

• 1D: 2.26%
• 1M: -1.79%
• YTD: -26.42%
• 6M: -38.18%
• 1Y: -3.68%
• 3Y*: 14.74%
• 5Y*: 14.98%
• 10Y*: 15.34%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ARWR vs. ALNY - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ARWR Arrowhead Pharmaceuticals, Inc.	9.28%	253.14%	-38.56%	-24.56%	-38.82%	-13.59%	20.97%	410.71%	237.50%	137.42%
ALNY Alnylam Pharmaceuticals, Inc.	-26.42%	68.99%	22.94%	-19.46%	40.14%	30.48%	12.85%	57.96%	-42.61%	239.34%

Correlation

The correlation between ARWR and ALNY is 0.23, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.23
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (5Y) Calculated over the trailing 5-year period	0.42
Correlation (10Y) Calculated over the trailing 10-year period	0.40
Correlation (All Time) Calculated using the full available price history since Jun 2, 2004	0.29

The correlation between ARWR and ALNY shifts across timeframes, from 0.23 (1 year) to 0.42 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap ARWR : $10.33B ALNY : $40.44B
EPS ARWR : -$2.16 ALNY : $4.26
PS Ratio ARWR : 16.27 ALNY : 9.24
PB Ratio ARWR : 17.25 ALNY : 37.61
Total Revenue (TTM) ARWR : $622.01M ALNY : $4.29B
Gross Profit (TTM) ARWR : $529.27M ALNY : $2.51B
EBITDA (TTM) ARWR : -$168.38M ALNY : $729.86M

Return for Risk

ARWR vs. ALNY — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ARWR

ARWR Risk / Return Rank: 98
ARWR Sharpe Ratio Rank: 99
ARWR Sortino Ratio Rank: 97
ARWR Omega Ratio Rank: 95
ARWR Calmar Ratio Rank: 98
ARWR Martin Ratio Rank: 98

ALNY

ALNY Risk / Return Rank: 35
ALNY Sharpe Ratio Rank: 36
ALNY Sortino Ratio Rank: 32
ALNY Omega Ratio Rank: 33
ALNY Calmar Ratio Rank: 37
ALNY Martin Ratio Rank: 38

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ARWR vs. ALNY - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Arrowhead Pharmaceuticals, Inc. (ARWR) and Alnylam Pharmaceuticals, Inc. (ALNY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ARWR	ALNY	Difference
Sharpe ratio Return per unit of total volatility	5.22	-0.10	+5.32
Sortino ratio Return per unit of downside risk	4.69	0.11	+4.58
Omega ratio Gain probability vs. loss probability	1.59	1.01	+0.58
Calmar ratio Return relative to maximum drawdown	13.77	-0.09	+13.86
Martin ratio Return relative to average drawdown	37.74	-0.16	+37.90
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ARWR vs. ALNY - Sharpe Ratio Comparison

The current ARWR Sharpe Ratio is 5.22, which is higher than the ALNY Sharpe Ratio of -0.10. The chart below compares the historical Sharpe Ratios of ARWR and ALNY, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ARWR	ALNY	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	5.22	-0.10	+5.32
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.01	0.31	-0.32
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.38	0.29	+0.09
Sharpe Ratio (All Time) Calculated using the full available price history	-0.01	0.32	-0.33

Drawdowns

ARWR vs. ALNY - Drawdown Comparison

The maximum ARWR drawdown since its inception was -99.24%, which is greater than ALNY's maximum drawdown of -83.58%. Use the drawdown chart below to compare losses from any high point for ARWR and ALNY.

Drawdown Indicators

	ARWR	ALNY	Difference
Max Drawdown Largest peak-to-trough decline	-99.24%	-83.58%	-15.66%
Max Drawdown (1Y) Largest decline over 1 year	-24.64%	-42.01%	+17.37%
Max Drawdown (3Y) Largest decline over 3 years	-74.70%	-42.01%	-32.69%
Max Drawdown (5Y) Largest decline over 5 years	-88.94%	-42.46%	-46.48%
Max Drawdown (10Y) Largest decline over 10 years	-88.96%	-59.95%	-29.01%
Current Drawdown Current decline from peak	-55.35%	-40.44%	-14.91%
Average Drawdown Average peak-to-trough decline	-81.24%	-30.59%	-50.65%
Ulcer Index Depth and duration of drawdowns from previous peaks	8.97%	22.83%	-13.86%

Volatility

ARWR vs. ALNY - Volatility Comparison

Arrowhead Pharmaceuticals, Inc. (ARWR) has a higher volatility of 17.17% compared to Alnylam Pharmaceuticals, Inc. (ALNY) at 8.81%. This indicates that ARWR's price experiences larger fluctuations and is considered to be riskier than ALNY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ARWR	ALNY	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.17%	8.81%	+8.36%
Volatility (6M) Calculated over the trailing 6-month period	39.41%	26.06%	+13.35%
Volatility (1Y) Calculated over the trailing 1-year period	65.03%	36.52%	+28.51%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	65.03%	48.85%	+16.18%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	74.14%	53.68%	+20.46%

Dividends

ARWR vs. ALNY - Dividend Comparison

Neither ARWR nor ALNY has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ARWR and ALNY in my portfolio?

ARWR and ALNY have a correlation of 0.23, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ARWR or ALNY?

ARWR has higher volatility (17.17%) compared to ALNY (8.81%). In terms of maximum drawdown, ARWR dropped -99.24% vs ALNY's -83.58%.

Which has better risk-adjusted returns?

ARWR currently has the higher Sharpe Ratio (5.22 vs -0.10), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.