ARWR vs. QQQ

Last updated Jun 4, 2026

ARWR (Arrowhead Pharmaceuticals, Inc.) is a stock, while QQQ (Invesco QQQ ETF) is Nasdaq-100 fund tracking the NASDAQ-100 Index. Over the past 10 years, ARWR returned 28.05%/yr vs 21.94%/yr for QQQ. At a 0.25 correlation, their price movements are largely independent.

Performance

ARWR vs. QQQ - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Arrowhead Pharmaceuticals, Inc. (ARWR) and Invesco QQQ ETF (QQQ). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ARWR achieves a 9.28% return, which is significantly lower than QQQ's 21.30% return. Over the past 10 years, ARWR has outperformed QQQ with an annualized return of 28.05%, while QQQ has yielded a comparatively lower 21.94% annualized return.

ARWR

• 1D: 2.44%
• 1M: -5.03%
• YTD: 9.28%
• 6M: 11.49%
• 1Y: 336.79%
• 3Y*: 26.25%
• 5Y*: -0.96%
• 10Y*: 28.05%

QQQ

• 1D: -0.26%
• 1M: 10.60%
• YTD: 21.30%
• 6M: 19.66%
• 1Y: 41.82%
• 3Y*: 28.78%
• 5Y*: 17.97%
• 10Y*: 21.94%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ARWR vs. QQQ - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ARWR Arrowhead Pharmaceuticals, Inc.	9.28%	253.14%	-38.56%	-24.56%	-38.82%	-13.59%	20.97%	410.71%	237.50%	137.42%
QQQ Invesco QQQ ETF	21.30%	20.77%	25.58%	54.86%	-32.58%	27.42%	48.62%	38.96%	-0.13%	32.66%

Correlation

The correlation between ARWR and QQQ is 0.31, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.31
Correlation (3Y) Calculated over the trailing 3-year period	0.32
Correlation (5Y) Calculated over the trailing 5-year period	0.40
Correlation (10Y) Calculated over the trailing 10-year period	0.40
Correlation (All Time) Calculated using the full available price history since Mar 11, 1999	0.25

The correlation between ARWR and QQQ shifts across timeframes, from 0.25 (all time) to 0.40 (5 years), reflecting how their relationship changes across market environments.

Return for Risk

ARWR vs. QQQ — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ARWR

ARWR Risk / Return Rank: 98
ARWR Sharpe Ratio Rank: 99
ARWR Sortino Ratio Rank: 97
ARWR Omega Ratio Rank: 95
ARWR Calmar Ratio Rank: 98
ARWR Martin Ratio Rank: 98

QQQ

QQQ Risk / Return Rank: 73
QQQ Sharpe Ratio Rank: 79
QQQ Sortino Ratio Rank: 75
QQQ Omega Ratio Rank: 74
QQQ Calmar Ratio Rank: 69
QQQ Martin Ratio Rank: 71

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ARWR vs. QQQ - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Arrowhead Pharmaceuticals, Inc. (ARWR) and Invesco QQQ ETF (QQQ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ARWR	QQQ	Difference
Sharpe ratio: Return per unit of total volatility	5.22	2.64	+2.58
Sortino ratio: Return per unit of downside risk	4.69	3.45	+1.25
Omega ratio: Gain probability vs. loss probability	1.59	1.45	+0.14
Calmar ratio: Return relative to maximum drawdown	13.77	3.51	+10.26
Martin ratio: Return relative to average drawdown	37.74	13.49	+24.25
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ARWR vs. QQQ - Sharpe Ratio Comparison

The current ARWR Sharpe Ratio is 5.22, which is higher than the QQQ Sharpe Ratio of 2.64. The chart below compares the historical Sharpe Ratios of ARWR and QQQ, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ARWR	QQQ	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	5.22	2.64	+2.58
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.01	0.81	-0.82
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.38	0.99	-0.61
Sharpe Ratio (All Time) Calculated using the full available price history	-0.01	0.41	-0.42

Drawdowns

ARWR vs. QQQ - Drawdown Comparison

The maximum ARWR drawdown since its inception was -99.24%, which is greater than QQQ's maximum drawdown of -82.97%. Use the drawdown chart below to compare losses from any high point for ARWR and QQQ.

Drawdown Indicators

	ARWR	QQQ	Difference
Max Drawdown Largest peak-to-trough decline	-99.24%	-82.97%	-16.27%
Max Drawdown (1Y) Largest decline over 1 year	-24.64%	-11.96%	-12.68%
Max Drawdown (3Y) Largest decline over 3 years	-74.70%	-22.77%	-51.93%
Max Drawdown (5Y) Largest decline over 5 years	-88.94%	-35.12%	-53.82%
Max Drawdown (10Y) Largest decline over 10 years	-88.96%	-35.12%	-53.84%
Current Drawdown Current decline from peak	-55.35%	-0.26%	-55.09%
Average Drawdown Average peak-to-trough decline	-81.24%	-32.79%	-48.45%
Ulcer Index Depth and duration of drawdowns from previous peaks	8.97%	3.11%	+5.86%

Volatility

ARWR vs. QQQ - Volatility Comparison

Arrowhead Pharmaceuticals, Inc. (ARWR) has a higher volatility of 17.17% compared to Invesco QQQ ETF (QQQ) at 4.49%. This indicates that ARWR's price experiences larger fluctuations and is considered to be riskier than QQQ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ARWR	QQQ	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.17%	4.49%	+12.68%
Volatility (6M) Calculated over the trailing 6-month period	39.41%	12.10%	+27.31%
Volatility (1Y) Calculated over the trailing 1-year period	65.03%	15.94%	+49.09%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	65.03%	22.38%	+42.65%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	74.14%	22.29%	+51.85%

Dividends

ARWR vs. QQQ - Dividend Comparison

ARWR has not paid dividends to shareholders, while QQQ's dividend yield for the trailing twelve months is around 0.38%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
ARWR Arrowhead Pharmaceuticals, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
QQQ Invesco QQQ ETF	0.38%	0.45%	0.56%	0.62%	0.80%	0.43%	0.55%	0.74%	0.91%	0.84%	1.06%	0.99%

Frequently Asked Questions

Can I hold both ARWR and QQQ in my portfolio?

ARWR and QQQ have a correlation of 0.31, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ARWR or QQQ?

ARWR has higher volatility (17.17%) compared to QQQ (4.49%). In terms of maximum drawdown, ARWR dropped -99.24% vs QQQ's -82.97%.

Which has better risk-adjusted returns?

ARWR currently has the higher Sharpe Ratio (5.22 vs 2.64), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.