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State Street Health Care Select Sector SPDR Premium Income ETF (XLVI) belongs to the Derivative Income category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with XLVI. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.

Cheapest Alternatives to XLVI

XLVI charges 0.35% annually. There are 11 ETFs in the Derivative Income category with lower expense ratios, going as low as 0.10%.


Best Risk-Adjusted Alternatives to XLVI

Among 163 ETFs in the Derivative Income category with risk / return rank data, the top risk-adjusted alternatives shown here go as high as 96.


Top Performing XLVI Alternatives (YTD)

XLVI is at 2.99% YTD. There are 132 ETFs in the Derivative Income category with higher YTD returns, going as high as 19,132.59%.


Lowest Volatility Alternatives to XLVI

XLVI has 11.05% 1-year volatility. There are 60 ETFs in the Derivative Income category with lower 1-year volatility, going as low as 2.98%.


Lowest Drawdown Alternatives to XLVI

Among 165 ETFs in the Derivative Income category with 1-year drawdown data, the lowest-drawdown alternatives shown here go as shallow as -1.31%.


Other ETFs from State Street

The 10 most viewed State Street ETFs shown here include SPY, GLD, XLK and span 10 categories. AUM among these funds goes as high as $765B.


Often Compared With XLVI

Investors most often compare XLVI with TMED, VHT, XLV. These 20 comparison targets span 10 categories, based on PortfoliosLab usage data.


SymbolNameCategoryRisk / Return RankYTD ReturnAUMInception
T. Rowe Price Health Care ETFHealth & Biotech Equities, Actively Managed
66
10.47%
Jun 2025XLVI vs TMED
Vanguard Health Care ETFHealth & Biotech Equities
38
0.68%
19.00BJan 2004XLVI vs VHT
State Street Health Care Select Sector SPDR ETFHealth & Biotech Equities
33
-0.09%
38.47BDec 1998XLVI vs XLV
First Trust Health Care AlphaDEX FundHealth & Biotech Equities
30
4.51%
900.57MMay 2007XLVI vs FXH
abrdn Bloomberg All Commodity Longer Dated Strateg...Commodities
40
9.08%
402.86MMar 2017XLVI vs BCD
Dividend Performers ETFDerivative Income20.88MDec 2018XLVI vs IPDP
Fidelity MSCI Energy Index ETFEnergy Equities
44
21.34%
1.90BOct 2013XLVI vs FENY
Roundhill AVGO WeeklyPay™ ETFDerivative Income, Leveraged Equities
9.31%
49.79MJul 2025XLVI vs AVGW
Fidelity Disruptive Medicine ETFHealth & Biotech Equities
19
-0.22%
40.98MApr 2020XLVI vs FMED
Invesco S&P 500 Equal Weight Health Care ETFHealth & Biotech Equities, S&P 500, Equal Weight
24
1.81%
699.48MNov 2006XLVI vs RSPH
SPDR S&P Pharmaceuticals ETFHealth & Biotech Equities
86
15.31%
364.01MJun 2006XLVI vs XPH
WEBs Health Care XLV Defined Volatility ETFHealth & Biotech Equities
-1.06%
Jul 2025XLVI vs DVXV
WisdomTree Interest Rate Hedged U.S. Aggregate Bon...Nontraditional Bonds
82
2.26%
116.65MDec 2013XLVI vs AGZD
Horizon Kinetics SPAC Active ETFHealth & Biotech Equities
18
3.29%
10.10MJun 2007XLVI vs SPAQ
Simplify Health Care ETFHealth & Biotech Equities
43
4.23%
332.09MOct 2021XLVI vs PINK
First Trust Nasdaq Lux Digital Health Solutions ET...Health & Biotech Equities
11
-4.18%
2.65MMar 2022XLVI vs EKG
First Trust NYSE Arca Biotechnology UCITS ETF Clas...Health & Biotech Equities
72
13.83%
11.21MXLVI vs FBTU.L
AdvisorShares Psychedelics ETFHealth & Biotech Equities
57
26.51%
33.07MSep 2021XLVI vs PSIL
Parametric Equity Premium Income ETFDerivative Income
37
7.33%
398.58MOct 2023XLVI vs PAPI
YieldMax MRNA Option Income Strategy ETFDerivative Income, Dividend
42
74.80%
121.45MOct 2023XLVI vs MRNY

Compare XLVI with Any Fund or Stock

Compare XLVI with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.


 

Diversifiers

Pair XLVI with funds that move differently

State Street Health Care Select Sector SPDR Premium Income ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to XLVI.

Explore XLVI Diversifiers