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State Street Health Care Select Sector SPDR Premium Income ETF (XLVI) belongs to the Derivative Income category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with XLVI. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.

Cheapest Alternatives to XLVI

XLVI charges 0.35% annually. There are 11 ETFs in the Derivative Income category with lower expense ratios, going as low as 0.10%.


Best Risk-Adjusted Alternatives to XLVI

Among 142 ETFs in the Derivative Income category with risk / return rank data, the top risk-adjusted alternatives shown here go as high as 97.


Top Performing XLVI Alternatives (YTD)

XLVI is at -0.67% YTD. There are 153 ETFs in the Derivative Income category with higher YTD returns, going as high as 363.23%.


Lowest Volatility Alternatives to XLVI

XLVI has 10.94% 1-year volatility. There are 62 ETFs in the Derivative Income category with lower 1-year volatility, going as low as 0.00%.


Lowest Drawdown Alternatives to XLVI

Among 142 ETFs in the Derivative Income category with 1-year drawdown data, the lowest-drawdown alternatives shown here go as shallow as -1.31%.


Other ETFs from State Street

The 10 most viewed State Street ETFs shown here include SPY, GLD, XLK and span 10 categories. AUM among these funds goes as high as $781B.


Often Compared With XLVI

Investors most often compare XLVI with TMED, XLV, VHT. These 20 comparison targets span 8 categories, based on PortfoliosLab usage data.


SymbolNameCategoryRisk / Return RankYTD ReturnAUMInception
T. Rowe Price Health Care ETFHealth & Biotech Equities, Actively Managed
3.87%
Jun 2025XLVI vs TMED
State Street Health Care Select Sector SPDR ETFHealth & Biotech Equities
24
-4.29%
38.66BDec 1998XLVI vs XLV
Vanguard Health Care ETFHealth & Biotech Equities
27
-4.02%
18.50BJan 2004XLVI vs VHT
abrdn Bloomberg All Commodity Longer Dated Strateg...Commodities
71
20.45%
423.65MMar 2017XLVI vs BCD
First Trust Health Care AlphaDEX FundHealth & Biotech Equities
24
0.68%
874.08MMay 2007XLVI vs FXH
Roundhill AVGO WeeklyPay™ ETFDerivative Income, Leveraged Equities
43.84%
57.50MJul 2025XLVI vs AVGW
Fidelity MSCI Energy Index ETFEnergy Equities
64
32.28%
2.03BOct 2013XLVI vs FENY
WEBs Health Care XLV Defined Volatility ETFHealth & Biotech Equities
-6.26%
Jul 2025XLVI vs DVXV
SPDR S&P Pharmaceuticals ETFHealth & Biotech Equities
55
0.66%
354.21MJun 2006XLVI vs XPH
Fidelity Disruptive Medicine ETFHealth & Biotech Equities
11
-9.33%
57.69MApr 2020XLVI vs FMED
AdvisorShares Psychedelics ETFHealth & Biotech Equities
48
20.15%
35.56MSep 2021XLVI vs PSIL
Simplify Health Care ETFHealth & Biotech Equities
44
2.39%
269.79MOct 2021XLVI vs PINK
First Trust Nasdaq Lux Digital Health Solutions ET...Health & Biotech Equities
8
-10.11%
2.59MMar 2022XLVI vs EKG
WisdomTree Interest Rate Hedged U.S. Aggregate Bon...Nontraditional Bonds
69
2.22%
92.79MDec 2013XLVI vs AGZD
Strive U.S. Energy ETFEnergy Equities
55
31.26%
282.56MAug 2022XLVI vs DRLL
Invesco S&P 500 Equal Weight Health Care ETFHealth & Biotech Equities, S&P 500
18
-2.71%
635.88MNov 2006XLVI vs RSPH
First Trust NYSE Arca Biotechnology UCITS ETF Clas...Health & Biotech Equities
45
4.21%
12.84MXLVI vs FBTU.L
Parametric Equity Premium Income ETFDerivative Income
33
5.81%
388.80MOct 2023XLVI vs PAPI
Horizon Kinetics SPAC Active ETFHealth & Biotech Equities
20
2.81%
10.01MJun 2007XLVI vs SPAQ
Peerless Option Income Wheel ETFDerivative Income
84
5.22%
21.33MMay 2024XLVI vs WEEL

Compare XLVI with Any Fund or Stock

Compare XLVI with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.


 

Diversifiers

Pair XLVI with funds that move differently

State Street Health Care Select Sector SPDR Premium Income ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to XLVI.

Explore XLVI Diversifiers