XLVI vs. TMED

Last updated Jun 3, 2026

XLVI (State Street Health Care Select Sector SPDR Premium Income ETF) and TMED (T. Rowe Price Health Care ETF) are both exchange-traded funds - XLVI is a Derivative Income fund actively managed by State Street, while TMED is a Health & Biotech Equities fund managed by T. Rowe Price. Their correlation of 0.85 suggests significant overlap in exposure. XLVI charges 0.35%/yr vs 0.44%/yr for TMED.

Performance

XLVI vs. TMED - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in State Street Health Care Select Sector SPDR Premium Income ETF (XLVI) and T. Rowe Price Health Care ETF (TMED). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, XLVI achieves a -1.33% return, which is significantly lower than TMED's 2.81% return.

XLVI

• 1D: -0.73%
• 1M: 1.42%
• YTD: -1.33%
• 6M: 0.46%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

TMED

• 1D: -2.33%
• 1M: 1.95%
• YTD: 2.81%
• 6M: 4.16%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

XLVI vs. TMED - Yearly Performance Comparison

	2026 (YTD)	2025
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	-1.33%	12.79%
TMED T. Rowe Price Health Care ETF	2.81%	21.62%

Correlation

The correlation between XLVI and TMED is 0.85, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (All Time) Calculated using the full available price history since Jul 31, 2025	0.85

Return for Risk

XLVI vs. TMED - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for State Street Health Care Select Sector SPDR Premium Income ETF (XLVI) and T. Rowe Price Health Care ETF (TMED). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

Sharpe Ratios by Period

	XLVI	TMED	Difference
Sharpe Ratio (All Time) Calculated using the full available price history	1.25	1.29	-0.04

Drawdowns

XLVI vs. TMED - Drawdown Comparison

The maximum XLVI drawdown since its inception was -8.14%, smaller than the maximum TMED drawdown of -11.11%. Use the drawdown chart below to compare losses from any high point for XLVI and TMED.

Drawdown Indicators

	XLVI	TMED	Difference
Max Drawdown Largest peak-to-trough decline	-8.14%	-11.11%	+2.97%
Current Drawdown Current decline from peak	-4.66%	-3.75%	-0.91%
Average Drawdown Average peak-to-trough decline	-1.94%	-2.59%	+0.65%

Volatility

Volatility by Period

	XLVI	TMED	Difference
Volatility (1Y) Calculated over the trailing 1-year period	10.94%	18.05%	-7.11%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	10.94%	18.05%	-7.11%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	10.94%	18.05%	-7.11%

XLVI vs. TMED - Expense Ratio Comparison

XLVI has a 0.35% expense ratio, which is lower than TMED's 0.44% expense ratio.

Dividends

XLVI vs. TMED - Dividend Comparison

XLVI's dividend yield for the trailing twelve months is around 11.61%, more than TMED's 0.53% yield.

Position	TTM	2025
TMED T. Rowe Price Health Care ETF	0.53%	0.54%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	11.61%	5.73%

Frequently Asked Questions

Can I hold both XLVI and TMED in my portfolio?

XLVI and TMED have a correlation of 0.85, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, XLVI or TMED?

On fees, XLVI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, XLVI or TMED?

XLVI is cheaper with a 0.35% expense ratio, compared with 0.44% for TMED.

Which ETF pays a higher dividend yield, XLVI or TMED?

XLVI has the higher dividend yield at 11.61%, compared with 0.53% for TMED.

What is the main difference between XLVI and TMED?

XLVI is categorized as Derivative Income, while TMED is Health & Biotech Equities. They also come from different issuers: State Street and T. Rowe Price. Their fees differ too: 0.35% for XLVI and 0.44% for TMED.