Roundhill Glp-1 & Weight Loss ETF (OZEM) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with OZEM. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to OZEM
OZEM charges 0.59% annually. There are 36 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | OZEM vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | OZEM vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | OZEM vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | OZEM vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | OZEM vs GSKH |
Best Risk-Adjusted Alternatives to OZEM
OZEM has a PortfoliosLab risk / return rank of 35. There are 44 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | OZEM vs BBC | |
| ALPS Medical Breakthroughs ETF | 94 | 213.08M | Dec 2014 | OZEM vs SBIO | |
| First Trust Nasdaq Pharmaceuticals ETF | 94 | 36.36M | Sep 2016 | OZEM vs FTXH | |
| iShares U.S. Pharmaceuticals ETF | 93 | 1.34B | May 2006 | OZEM vs IHE | |
| SPDR S&P Biotech ETF | 93 | 11.10B | Feb 2006 | OZEM vs XBI |
Top Performing OZEM Alternatives (YTD)
OZEM is at -3.86% YTD. There are 60 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 41.35%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 41.35% | 44.37M | Sep 2021 | OZEM vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 38.38% | 1.31B | Oct 2014 | OZEM vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 31.46% | 6.01M | Dec 2025 | OZEM vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 29.44% | 57.56M | Dec 2014 | OZEM vs BBC | |
| SPDR S&P Health Care Services ETF | 26.76% | 204.10M | Sep 2011 | OZEM vs XHS |
Lowest Volatility Alternatives to OZEM
OZEM has 24.28% 1-year volatility. There are 51 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | OZEM vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | OZEM vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.62% | 10.11M | Jun 2007 | OZEM vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 11.06% | 16.78M | Jul 2025 | OZEM vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.54% | 982.35K | Apr 2026 | OZEM vs MHIP |
Lowest Drawdown Alternatives to OZEM
OZEM has a 1-year max drawdown of -19.50%. There are 49 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | OZEM vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | OZEM vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | OZEM vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | OZEM vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | OZEM vs IHE |
Other ETFs from Roundhill
The 10 most viewed Roundhill ETFs shown here include MAGS, QDTE, CHAT and span 7 categories. AUM among these funds goes as high as $25B.
Often Compared With OZEM
Investors most often compare OZEM with HRTS, MGV, ^GSPC. These 19 comparison targets span 9 categories, based on PortfoliosLab usage data.
Compare OZEM with Any Fund or Stock
Compare OZEM with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair OZEM with funds that move differently
Roundhill Glp-1 & Weight Loss ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to OZEM.
Explore OZEM Diversifiers