OZEM vs. BBC

Last updated Apr 1, 2026

Compare and contrast key facts about Roundhill Glp-1 & Weight Loss ETF (OZEM) and Virtus LifeSci Biotech Clinical Trials ETF (BBC).

OZEM and BBC are both exchange-traded funds (ETFs), meaning they are traded on stock exchanges and can be bought and sold throughout the day. OZEM is an actively managed fund by Roundhill. It was launched on May 20, 2024. BBC is a passively managed fund by Virtus Investment Partners that tracks the performance of the LifeSci Biotechnology Clinical Trials Index. It was launched on Dec 16, 2014.

Performance

OZEM vs. BBC - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Roundhill Glp-1 & Weight Loss ETF (OZEM) and Virtus LifeSci Biotech Clinical Trials ETF (BBC). The values are adjusted to include any dividend payments, if applicable.

OZEM vs. BBC - Yearly Performance Comparison

	2026 (YTD)	2025	2024
OZEM Roundhill Glp-1 & Weight Loss ETF	-8.66%	41.87%	-3.78%
BBC Virtus LifeSci Biotech Clinical Trials ETF	7.95%	63.77%	-10.78%

Returns By Period

In the year-to-date period, OZEM achieves a -8.66% return, which is significantly lower than BBC's 7.95% return.

OZEM

• 1D: 3.13%
• 1M: -7.94%
• YTD: -8.66%
• 6M: 15.54%
• 1Y: 33.42%
• 3Y*: —
• 5Y*: —
• 10Y*: —

BBC

• 1D: 7.67%
• 1M: -1.98%
• YTD: 7.95%
• 6M: 55.07%
• 1Y: 141.32%
• 3Y*: 25.09%
• 5Y*: -3.63%
• 10Y*: 8.41%

*Multi-year figures are annualized to reflect compound growth (CAGR)

OZEM vs. BBC - Expense Ratio Comparison

OZEM has a 0.59% expense ratio, which is lower than BBC's 0.79% expense ratio.

BBC

Virtus LifeSci Biotech Clinical Trials ETF

OZEM

Roundhill Glp-1 & Weight Loss ETF

Return for Risk

OZEM vs. BBC — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

OZEM

OZEM Risk / Return Rank: 64
OZEM Sharpe Ratio Rank: 69
OZEM Sortino Ratio Rank: 70
OZEM Omega Ratio Rank: 59
OZEM Calmar Ratio Rank: 70
OZEM Martin Ratio Rank: 51

BBC

BBC Risk / Return Rank: 97
BBC Sharpe Ratio Rank: 98
BBC Sortino Ratio Rank: 97
BBC Omega Ratio Rank: 95
BBC Calmar Ratio Rank: 98
BBC Martin Ratio Rank: 98

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

OZEM vs. BBC - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Roundhill Glp-1 & Weight Loss ETF (OZEM) and Virtus LifeSci Biotech Clinical Trials ETF (BBC). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	OZEM	BBC	Difference
Sharpe ratio Return per unit of total volatility	1.22	3.52	-2.30
Sortino ratio Return per unit of downside risk	1.76	3.86	-2.09
Omega ratio Gain probability vs. loss probability	1.22	1.47	-0.26
Calmar ratio Return relative to maximum drawdown	1.78	6.54	-4.76
Martin ratio Return relative to average drawdown	4.85	25.10	-20.25
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

OZEM vs. BBC - Sharpe Ratio Comparison

The current OZEM Sharpe Ratio is 1.22, which is lower than the BBC Sharpe Ratio of 3.52. The chart below compares the historical Sharpe Ratios of OZEM and BBC, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	OZEM	BBC	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.22	3.52	-2.30
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.09	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.22	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.50	0.12	+0.38

Correlation

The correlation between OZEM and BBC is 0.60, which is considered to be moderate. This suggests that the two assets have some degree of positive relationship in their price movements. Moderate correlation can be acceptable for portfolio diversification, offering a balance between risk and potential returns.

Dividends

OZEM vs. BBC - Dividend Comparison

OZEM's dividend yield for the trailing twelve months is around 1.31%, less than BBC's 1.57% yield.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
OZEM Roundhill Glp-1 & Weight Loss ETF	1.31%	1.20%	0.22%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
BBC Virtus LifeSci Biotech Clinical Trials ETF	1.57%	1.70%	1.00%	0.34%	0.00%	0.00%	0.00%	0.00%	0.00%	2.09%	0.00%	0.51%

Drawdowns

OZEM vs. BBC - Drawdown Comparison

The maximum OZEM drawdown since its inception was -28.65%, smaller than the maximum BBC drawdown of -76.85%. Use the drawdown chart below to compare losses from any high point for OZEM and BBC.

Drawdown Indicators

	OZEM	BBC	Difference
Max Drawdown Largest peak-to-trough decline	-28.65%	-76.85%	+48.20%
Max Drawdown (1Y) Largest decline over 1 year	-19.11%	-18.03%	-1.08%
Max Drawdown (5Y) Largest decline over 5 years	—	-72.58%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-76.85%	—
Current Drawdown Current decline from peak	-15.70%	-30.71%	+15.01%
Average Drawdown Average peak-to-trough decline	-8.30%	-37.30%	+29.00%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.02%	5.05%	+1.97%

Volatility

OZEM vs. BBC - Volatility Comparison

The current volatility for Roundhill Glp-1 & Weight Loss ETF (OZEM) is 6.60%, while Virtus LifeSci Biotech Clinical Trials ETF (BBC) has a volatility of 13.21%. This indicates that OZEM experiences smaller price fluctuations and is considered to be less risky than BBC based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	OZEM	BBC	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.60%	13.21%	-6.61%
Volatility (6M) Calculated over the trailing 6-month period	17.54%	26.93%	-9.39%
Volatility (1Y) Calculated over the trailing 1-year period	27.62%	40.92%	-13.30%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.37%	39.30%	-13.93%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.37%	37.86%	-12.49%