OZEM vs. SBIO
Compare and contrast key facts about Roundhill Glp-1 & Weight Loss ETF (OZEM) and ALPS Medical Breakthroughs ETF (SBIO).
OZEM and SBIO are both exchange-traded funds (ETFs), meaning they are traded on stock exchanges and can be bought and sold throughout the day. OZEM is an actively managed fund by Roundhill. It was launched on May 20, 2024. SBIO is a passively managed fund by SS&C that tracks the performance of the S-Network Medical Breakthroughs Index. It was launched on Dec 31, 2014.
Performance
OZEM vs. SBIO - Performance Comparison
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OZEM vs. SBIO - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | |
|---|---|---|---|
OZEM Roundhill Glp-1 & Weight Loss ETF | -6.61% | 41.87% | -3.78% |
SBIO ALPS Medical Breakthroughs ETF | 3.20% | 55.07% | 0.94% |
Returns By Period
In the year-to-date period, OZEM achieves a -6.61% return, which is significantly lower than SBIO's 3.20% return.
OZEM
- 1D
- 2.24%
- 1M
- -4.47%
- YTD
- -6.61%
- 6M
- 13.53%
- 1Y
- 39.36%
- 3Y*
- —
- 5Y*
- —
- 10Y*
- —
SBIO
- 1D
- 0.99%
- 1M
- 3.89%
- YTD
- 3.20%
- 6M
- 36.23%
- 1Y
- 95.78%
- 3Y*
- 26.37%
- 5Y*
- 1.76%
- 10Y*
- 9.75%
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OZEM vs. SBIO - Expense Ratio Comparison
OZEM has a 0.59% expense ratio, which is higher than SBIO's 0.50% expense ratio.
Return for Risk
OZEM vs. SBIO — Risk / Return Rank
OZEM
SBIO
OZEM vs. SBIO - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Roundhill Glp-1 & Weight Loss ETF (OZEM) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| OZEM | SBIO | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | 1.43 | 2.92 | -1.49 |
Sortino ratioReturn per unit of downside risk | 2.01 | 3.57 | -1.56 |
Omega ratioGain probability vs. loss probability | 1.25 | 1.45 | -0.20 |
Calmar ratioReturn relative to maximum drawdown | 1.91 | 5.66 | -3.75 |
Martin ratioReturn relative to average drawdown | 5.21 | 19.94 | -14.73 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| OZEM | SBIO | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 1.43 | 2.92 | -1.49 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | — | 0.05 | — |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | — | 0.29 | — |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.55 | 0.23 | +0.33 |
Correlation
The correlation between OZEM and SBIO is 0.62, which is considered to be moderate. This suggests that the two assets have some degree of positive relationship in their price movements. Moderate correlation can be acceptable for portfolio diversification, offering a balance between risk and potential returns.
Dividends
OZEM vs. SBIO - Dividend Comparison
OZEM's dividend yield for the trailing twelve months is around 1.28%, while SBIO has not paid dividends to shareholders.
| TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
OZEM Roundhill Glp-1 & Weight Loss ETF | 1.28% | 1.20% | 0.22% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
SBIO ALPS Medical Breakthroughs ETF | 0.00% | 0.00% | 3.55% | 0.22% | 0.00% | 0.00% | 0.00% | 0.04% | 2.79% | 1.77% |
Drawdowns
OZEM vs. SBIO - Drawdown Comparison
The maximum OZEM drawdown since its inception was -28.65%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for OZEM and SBIO.
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Drawdown Indicators
| OZEM | SBIO | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -28.65% | -63.06% | +34.41% |
Max Drawdown (1Y)Largest decline over 1 year | -19.11% | -15.08% | -4.03% |
Max Drawdown (5Y)Largest decline over 5 years | — | -53.67% | — |
Max Drawdown (10Y)Largest decline over 10 years | — | -63.06% | — |
Current DrawdownCurrent decline from peak | -13.81% | -13.79% | -0.02% |
Average DrawdownAverage peak-to-trough decline | -8.31% | -28.70% | +20.39% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 6.98% | 4.28% | +2.70% |
Volatility
OZEM vs. SBIO - Volatility Comparison
The current volatility for Roundhill Glp-1 & Weight Loss ETF (OZEM) is 6.54%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 12.61%. This indicates that OZEM experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| OZEM | SBIO | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 6.54% | 12.61% | -6.07% |
Volatility (6M)Calculated over the trailing 6-month period | 17.55% | 22.09% | -4.54% |
Volatility (1Y)Calculated over the trailing 1-year period | 27.70% | 33.43% | -5.73% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 25.39% | 33.55% | -8.16% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 25.39% | 33.34% | -7.95% |