Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with BBC. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to BBC
BBC charges 0.79% annually. There are 52 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | BBC vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | BBC vs XLV | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | BBC vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | BBC vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | BBC vs GSKH |
Best Risk-Adjusted Alternatives to BBC
BBC has a PortfoliosLab risk / return rank of 96. No ETFs in the Health & Biotech Equities category have higher risk-adjusted ranks; the top alternatives shown here go as high as 95.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | BBC vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | BBC vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | BBC vs IHE | |
| iShares Neuroscience and Healthcare ETF | 93 | 5.85M | Aug 2022 | BBC vs IBRN | |
| First Trust Nasdaq Pharmaceuticals ETF | 93 | 36.36M | Sep 2016 | BBC vs FTXH |
Top Performing BBC Alternatives (YTD)
BBC is at 33.14% YTD. There are 3 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 40.11%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 40.11% | 1.31B | Oct 2014 | BBC vs ARKG | |
| AdvisorShares Psychedelics ETF | 35.29% | 44.37M | Sep 2021 | BBC vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 34.33% | 6.01M | Dec 2025 | BBC vs UNHW | |
| ALPS Medical Breakthroughs ETF | 27.56% | 213.08M | Dec 2014 | BBC vs SBIO | |
| SPDR S&P Biotech ETF | 27.53% | 11.10B | Feb 2006 | BBC vs XBI |
Lowest Volatility Alternatives to BBC
BBC has 36.18% 1-year volatility. There are 61 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | BBC vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | BBC vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.64% | 10.11M | Jun 2007 | BBC vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.87% | 16.78M | Jul 2025 | BBC vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.73% | 982.35K | Apr 2026 | BBC vs MHIP |
Lowest Drawdown Alternatives to BBC
BBC has a 1-year max drawdown of -15.10%. There are 36 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | BBC vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | BBC vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | BBC vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | BBC vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | BBC vs IHE |
Other ETFs from Virtus Investment Partners
The 10 most viewed Virtus Investment Partners ETFs shown here include PFFA, UTES, PFFR and span 10 categories. AUM among these funds goes as high as $2B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Virtus InfraCap U.S. Preferred Stock ETF | Preferred Stock/Convertible Bonds | 34 | 1.63% | 2.45B | May 2018 | BBC vs PFFA | |
| Virtus Reaves Utilities ETF | Utilities Equities | 19 | 4.78% | 1.39B | Sep 2015 | BBC vs UTES | |
| InfraCap REIT Preferred ETF | Preferred Stock/Convertible Bonds, REIT | 22 | 2.26% | 117.50M | Feb 2017 | BBC vs PFFR | |
| InfraCap MLP ETF | MLPs | 40 | 28.17% | 454.57M | Oct 2014 | BBC vs AMZA | |
| Virtus Terranova U.S. Quality Momentum ETF | Momentum, Large Cap Blend Equities | 31 | 8.38% | 243.22M | Nov 2020 | BBC vs JOET | |
| Virtus Private Credit ETF | Nontraditional Bonds | 1 | -10.57% | 30.38M | Feb 2019 | BBC vs VPC | |
| Virtus LifeSci Biotech Products ETF | Health & Biotech Equities | 91 | 22.76% | 98.34M | Dec 2014 | BBC vs BBP | |
| Virtus Newfleet ABS/MBS ETF | Mortgage Backed Securities | 80 | 1.78% | 112.35M | Feb 2021 | BBC vs VABS | |
| Virtus Duff & Phelps Clean Energy ETF | Sustainable | 59 | 13.17% | 5.97M | Aug 2021 | BBC vs VCLN | |
| Virtus Real Asset Income ETF | REIT | 82 | 22.38% | 18.07M | Feb 2019 | BBC vs VRAI |
Often Compared With BBC
Investors most often compare BBC with BBH, QQQ, LLY. These 20 comparison targets span 4 categories, based on PortfoliosLab usage data.
Compare BBC with Any Fund or Stock
Compare BBC with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair BBC with funds that move differently
Virtus LifeSci Biotech Clinical Trials ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to BBC.
Explore BBC Diversifiers