BBC vs. CANC

Last updated Jun 3, 2026

BBC (Virtus LifeSci Biotech Clinical Trials ETF) and CANC (Tema Oncology ETF) are both Health & Biotech Equities funds. BBC is passively managed, while CANC is actively managed. Over the past 3 years, BBC returned 19.82%/yr vs 107.71%/yr for CANC. A 0.54 correlation means they provide meaningful diversification when combined. BBC charges 0.79%/yr vs 0.75%/yr for CANC.

Performance

BBC vs. CANC - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Virtus LifeSci Biotech Clinical Trials ETF (BBC) and Tema Oncology ETF (CANC). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, BBC achieves a 8.17% return, which is significantly higher than CANC's 4.74% return.

BBC

• 1D: -4.90%
• 1M: -4.81%
• YTD: 8.17%
• 6M: 20.12%
• 1Y: 123.11%
• 3Y*: 19.82%
• 5Y*: -2.05%
• 10Y*: 7.60%

CANC

• 1D: -2.40%
• 1M: -2.10%
• YTD: 4.74%
• 6M: 5.93%
• 1Y: 49.25%
• 3Y*: 107.71%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

BBC vs. CANC - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
BBC Virtus LifeSci Biotech Clinical Trials ETF	8.17%	63.77%	-1.11%	-1.80%	-35.13%	-15.70%
CANC Tema Oncology ETF	4.74%	42.92%	-5.37%	510.51%	-85.34%	-51.82%

Correlation

The correlation between BBC and CANC is 0.81, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.81
Correlation (3Y) Calculated over the trailing 3-year period	0.77
Correlation (All Time) Calculated using the full available price history since Oct 1, 2021	0.54

Over the past year, BBC and CANC have become more correlated (0.81) than their long-term average of 0.54, meaning their price movements have been converging.

BBC vs. CANC - Sectors Allocation Comparison

Sectors	BBC	CANC
Healthcare	100.0%	100.0%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

BBC vs. CANC — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

BBC

BBC Risk / Return Rank: 90
BBC Sharpe Ratio Rank: 93
BBC Sortino Ratio Rank: 89
BBC Omega Ratio Rank: 79
BBC Calmar Ratio Rank: 96
BBC Martin Ratio Rank: 94

CANC

CANC Risk / Return Rank: 70
CANC Sharpe Ratio Rank: 63
CANC Sortino Ratio Rank: 65
CANC Omega Ratio Rank: 55
CANC Calmar Ratio Rank: 90
CANC Martin Ratio Rank: 78

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

BBC vs. CANC - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Virtus LifeSci Biotech Clinical Trials ETF (BBC) and Tema Oncology ETF (CANC). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	BBC	CANC	Difference
Sharpe ratio Return per unit of total volatility	3.49	2.14	+1.35
Sortino ratio Return per unit of downside risk	4.11	3.05	+1.07
Omega ratio Gain probability vs. loss probability	1.48	1.35	+0.13
Calmar ratio Return relative to maximum drawdown	8.82	5.75	+3.07
Martin ratio Return relative to average drawdown	28.55	15.57	+12.99
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

BBC vs. CANC - Sharpe Ratio Comparison

The current BBC Sharpe Ratio is 3.49, which is higher than the CANC Sharpe Ratio of 2.14. The chart below compares the historical Sharpe Ratios of BBC and CANC, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	BBC	CANC	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	3.49	2.14	+1.35
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.05	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.20	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.12	-0.04	+0.15

Drawdowns

BBC vs. CANC - Drawdown Comparison

The maximum BBC drawdown since its inception was -76.85%, smaller than the maximum CANC drawdown of -97.53%. Use the drawdown chart below to compare losses from any high point for BBC and CANC.

Drawdown Indicators

	BBC	CANC	Difference
Max Drawdown Largest peak-to-trough decline	-76.85%	-97.53%	+20.68%
Max Drawdown (1Y) Largest decline over 1 year	-15.10%	-8.67%	-6.43%
Max Drawdown (3Y) Largest decline over 3 years	-54.45%	-30.27%	-24.18%
Max Drawdown (5Y) Largest decline over 5 years	-72.44%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-76.85%	—	—
Current Drawdown Current decline from peak	-30.57%	-56.58%	+26.01%
Average Drawdown Average peak-to-trough decline	-37.14%	-73.20%	+36.06%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.66%	3.20%	+1.46%

Volatility

BBC vs. CANC - Volatility Comparison

Virtus LifeSci Biotech Clinical Trials ETF (BBC) has a higher volatility of 11.21% compared to Tema Oncology ETF (CANC) at 6.55%. This indicates that BBC's price experiences larger fluctuations and is considered to be riskier than CANC based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	BBC	CANC	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.21%	6.55%	+4.66%
Volatility (6M) Calculated over the trailing 6-month period	26.65%	16.79%	+9.86%
Volatility (1Y) Calculated over the trailing 1-year period	35.74%	23.11%	+12.63%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	39.31%	280.39%	-241.08%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	37.75%	280.39%	-242.64%

BBC vs. CANC - Expense Ratio Comparison

BBC has a 0.79% expense ratio, which is higher than CANC's 0.75% expense ratio.

Dividends

BBC vs. CANC - Dividend Comparison

BBC's dividend yield for the trailing twelve months is around 1.57%, more than CANC's 0.05% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
BBC Virtus LifeSci Biotech Clinical Trials ETF	1.57%	1.70%	1.00%	0.34%	0.00%	0.00%	0.00%	0.00%	0.00%	2.09%	0.00%	0.51%
CANC Tema Oncology ETF	0.05%	0.06%	3.00%	0.56%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both BBC and CANC in my portfolio?

BBC and CANC have a correlation of 0.81, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, BBC or CANC?

BBC has higher volatility (11.21%) compared to CANC (6.55%). In terms of maximum drawdown, BBC dropped -76.85% vs CANC's -97.53%.

Which ETF is better, BBC or CANC?

On 3-year performance, CANC leads with 107.71% vs 19.82% for BBC. On fees, CANC is cheaper at 0.75% per year. On volatility, CANC has been the lower-risk option at 6.55%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, BBC or CANC?

Over the 3-year period, CANC has performed better with a 107.71% return vs 19.82%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, BBC or CANC?

CANC is cheaper with a 0.75% expense ratio, compared with 0.79% for BBC.

Which ETF pays a higher dividend yield, BBC or CANC?

BBC has the higher dividend yield at 1.57%, compared with 0.05% for CANC.

What is the main difference between BBC and CANC?

They also come from different issuers: Virtus Investment Partners and Tema. Their fees differ too: 0.79% for BBC and 0.75% for CANC.

Which has better risk-adjusted returns?

BBC currently has the higher Sharpe Ratio (3.49 vs 2.14), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.