BBC vs. XLVI

Last updated Jun 3, 2026

BBC (Virtus LifeSci Biotech Clinical Trials ETF) and XLVI (State Street Health Care Select Sector SPDR Premium Income ETF) are both exchange-traded funds - BBC is a Health & Biotech Equities fund tracking the LifeSci Biotechnology Clinical Trials Index, while XLVI is a Derivative Income fund actively managed by State Street. BBC is passively managed, while XLVI is actively managed. At a 0.39 correlation, their price movements are largely independent. BBC charges 0.79%/yr vs 0.35%/yr for XLVI.

Performance

BBC vs. XLVI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Virtus LifeSci Biotech Clinical Trials ETF (BBC) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, BBC achieves a 8.17% return, which is significantly higher than XLVI's -1.33% return.

BBC

• 1D: -4.90%
• 1M: -4.81%
• YTD: 8.17%
• 6M: 20.12%
• 1Y: 123.11%
• 3Y*: 19.82%
• 5Y*: -2.05%
• 10Y*: 7.60%

XLVI

• 1D: -0.73%
• 1M: 1.42%
• YTD: -1.33%
• 6M: 0.46%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

BBC vs. XLVI - Yearly Performance Comparison

	2026 (YTD)	2025
BBC Virtus LifeSci Biotech Clinical Trials ETF	8.17%	77.19%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	-1.33%	12.79%

Correlation

The correlation between BBC and XLVI is 0.39, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (All Time) Calculated using the full available price history since Jul 31, 2025	0.39

BBC vs. XLVI - Sectors Allocation Comparison

Sectors	BBC	XLVI
Healthcare	100.0%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	100.6%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

BBC vs. XLVI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

BBC

BBC Risk / Return Rank: 90
BBC Sharpe Ratio Rank: 93
BBC Sortino Ratio Rank: 89
BBC Omega Ratio Rank: 79
BBC Calmar Ratio Rank: 96
BBC Martin Ratio Rank: 94

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

BBC vs. XLVI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Virtus LifeSci Biotech Clinical Trials ETF (BBC) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	BBC	XLVI	Difference
Sharpe ratio Return per unit of total volatility	3.49	—	—
Sortino ratio Return per unit of downside risk	4.11	—	—
Omega ratio Gain probability vs. loss probability	1.48	—	—
Calmar ratio Return relative to maximum drawdown	8.82	—	—
Martin ratio Return relative to average drawdown	28.55	—	—
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

Sharpe Ratios by Period

	BBC	XLVI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	3.49	—	—
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.05	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.20	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.12	1.25	-1.13

Drawdowns

BBC vs. XLVI - Drawdown Comparison

The maximum BBC drawdown since its inception was -76.85%, which is greater than XLVI's maximum drawdown of -8.14%. Use the drawdown chart below to compare losses from any high point for BBC and XLVI.

Drawdown Indicators

	BBC	XLVI	Difference
Max Drawdown Largest peak-to-trough decline	-76.85%	-8.14%	-68.71%
Max Drawdown (1Y) Largest decline over 1 year	-15.10%	—	—
Max Drawdown (3Y) Largest decline over 3 years	-54.45%	—	—
Max Drawdown (5Y) Largest decline over 5 years	-72.44%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-76.85%	—	—
Current Drawdown Current decline from peak	-30.57%	-4.66%	-25.91%
Average Drawdown Average peak-to-trough decline	-37.14%	-1.94%	-35.20%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.66%	—	—

Volatility

Volatility by Period

	BBC	XLVI	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.21%	—	—
Volatility (6M) Calculated over the trailing 6-month period	26.65%	—	—
Volatility (1Y) Calculated over the trailing 1-year period	35.74%	10.94%	+24.80%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	39.31%	10.94%	+28.37%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	37.75%	10.94%	+26.81%

BBC vs. XLVI - Expense Ratio Comparison

BBC has a 0.79% expense ratio, which is higher than XLVI's 0.35% expense ratio.

Dividends

BBC vs. XLVI - Dividend Comparison

BBC's dividend yield for the trailing twelve months is around 1.57%, less than XLVI's 11.61% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
BBC Virtus LifeSci Biotech Clinical Trials ETF	1.57%	1.70%	1.00%	0.34%	0.00%	0.00%	0.00%	0.00%	0.00%	2.09%	0.00%	0.51%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	11.61%	5.73%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both BBC and XLVI in my portfolio?

BBC and XLVI have a correlation of 0.39, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, BBC or XLVI?

On fees, XLVI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, BBC or XLVI?

XLVI is cheaper with a 0.35% expense ratio, compared with 0.79% for BBC.

Which ETF pays a higher dividend yield, BBC or XLVI?

XLVI has the higher dividend yield at 11.61%, compared with 1.57% for BBC.

What is the main difference between BBC and XLVI?

BBC is categorized as Health & Biotech Equities, while XLVI is Derivative Income. They also come from different issuers: Virtus Investment Partners and State Street. Their fees differ too: 0.79% for BBC and 0.35% for XLVI.