IONS vs. ALNY
Compare and contrast key facts about Ionis Pharmaceuticals, Inc. (IONS) and Alnylam Pharmaceuticals, Inc. (ALNY).
Performance
IONS vs. ALNY - Performance Comparison
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IONS vs. ALNY - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
IONS Ionis Pharmaceuticals, Inc. | -5.08% | 126.29% | -30.90% | 33.94% | 24.12% | -46.18% | -6.41% | 11.75% | 7.48% | 5.16% |
ALNY Alnylam Pharmaceuticals, Inc. | -16.79% | 68.99% | 22.94% | -19.46% | 40.14% | 30.48% | 12.85% | 57.96% | -42.61% | 239.34% |
Fundamentals
IONS:
$12.16B
ALNY:
$45.09B
IONS:
-$2.26
ALNY:
$2.33
IONS:
13.40
ALNY:
11.98
IONS:
24.88
ALNY:
57.14
IONS:
$943.38M
ALNY:
$3.71B
IONS:
$927.39M
ALNY:
$3.04B
IONS:
-$288.11M
ALNY:
$472.68M
Returns By Period
In the year-to-date period, IONS achieves a -5.08% return, which is significantly higher than ALNY's -16.79% return. Over the past 10 years, IONS has underperformed ALNY with an annualized return of 6.23%, while ALNY has yielded a comparatively higher 17.71% annualized return.
IONS
- 1D
- 3.54%
- 1M
- -7.47%
- YTD
- -5.08%
- 6M
- 14.78%
- 1Y
- 148.89%
- 3Y*
- 28.08%
- 5Y*
- 10.76%
- 10Y*
- 6.23%
ALNY
- 1D
- 4.68%
- 1M
- -0.62%
- YTD
- -16.79%
- 6M
- -27.44%
- 1Y
- 22.54%
- 3Y*
- 18.21%
- 5Y*
- 18.47%
- 10Y*
- 17.71%
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Return for Risk
IONS vs. ALNY — Risk / Return Rank
IONS
ALNY
IONS vs. ALNY - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Ionis Pharmaceuticals, Inc. (IONS) and Alnylam Pharmaceuticals, Inc. (ALNY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| IONS | ALNY | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | 2.96 | 0.55 | +2.41 |
Sortino ratioReturn per unit of downside risk | 4.28 | 1.05 | +3.23 |
Omega ratioGain probability vs. loss probability | 1.57 | 1.14 | +0.43 |
Calmar ratioReturn relative to maximum drawdown | 7.25 | 0.62 | +6.64 |
Martin ratioReturn relative to average drawdown | 25.04 | 1.38 | +23.66 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| IONS | ALNY | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 2.96 | 0.55 | +2.41 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.25 | 0.38 | -0.13 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.13 | 0.33 | -0.20 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.10 | 0.34 | -0.23 |
Correlation
The correlation between IONS and ALNY is 0.47, which is considered to be moderate. This suggests that the two assets have some degree of positive relationship in their price movements. Moderate correlation can be acceptable for portfolio diversification, offering a balance between risk and potential returns.
Dividends
IONS vs. ALNY - Dividend Comparison
Neither IONS nor ALNY has paid dividends to shareholders.
Drawdowns
IONS vs. ALNY - Drawdown Comparison
The maximum IONS drawdown since its inception was -91.42%, which is greater than ALNY's maximum drawdown of -83.58%. Use the drawdown chart below to compare losses from any high point for IONS and ALNY.
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Drawdown Indicators
| IONS | ALNY | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -91.42% | -83.58% | -7.84% |
Max Drawdown (1Y)Largest decline over 1 year | -19.45% | -37.57% | +18.12% |
Max Drawdown (5Y)Largest decline over 5 years | -52.36% | -42.46% | -9.90% |
Max Drawdown (10Y)Largest decline over 10 years | -70.39% | -59.95% | -10.44% |
Current DrawdownCurrent decline from peak | -13.19% | -32.64% | +19.45% |
Average DrawdownAverage peak-to-trough decline | -52.59% | -30.53% | -22.06% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 5.63% | 16.81% | -11.18% |
Volatility
IONS vs. ALNY - Volatility Comparison
Ionis Pharmaceuticals, Inc. (IONS) and Alnylam Pharmaceuticals, Inc. (ALNY) have volatilities of 10.99% and 10.49%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| IONS | ALNY | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 10.99% | 10.49% | +0.50% |
Volatility (6M)Calculated over the trailing 6-month period | 22.34% | 25.91% | -3.57% |
Volatility (1Y)Calculated over the trailing 1-year period | 50.77% | 41.46% | +9.31% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 42.73% | 48.70% | -5.97% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 48.55% | 54.25% | -5.70% |
Financials
IONS vs. ALNY - Financials Comparison
This section allows you to compare key financial metrics between Ionis Pharmaceuticals, Inc. and Alnylam Pharmaceuticals, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities