IONS vs. ABBV
IONS (Ionis Pharmaceuticals, Inc.) and ABBV (AbbVie Inc.) are both stocks. Both are in the Healthcare sector — IONS in Biotechnology, ABBV in Drug Manufacturers - General. Over the past 10 years, IONS returned 13.21%/yr vs 19.47%/yr for ABBV. At a 0.28 correlation, their price movements are largely independent.
Performance
IONS vs. ABBV - Performance Comparison
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Returns By Period
In the year-to-date period, IONS achieves a -3.94% return, which is significantly lower than ABBV's 4.43% return. Over the past 10 years, IONS has underperformed ABBV with an annualized return of 13.21%, while ABBV has yielded a comparatively higher 19.47% annualized return.
IONS
- 1D
- 0.13%
- 1M
- 0.57%
- YTD
- -3.94%
- 6M
- -5.40%
- 1Y
- 101.73%
- 3Y*
- 24.22%
- 5Y*
- 14.60%
- 10Y*
- 13.21%
ABBV
- 1D
- 2.07%
- 1M
- 8.84%
- YTD
- 4.43%
- 6M
- 4.29%
- 1Y
- 31.92%
- 3Y*
- 24.36%
- 5Y*
- 19.80%
- 10Y*
- 19.47%
IONS vs. ABBV - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
IONS Ionis Pharmaceuticals, Inc. | -3.94% | 126.29% | -30.90% | 33.94% | 24.12% | -46.18% | -6.41% | 11.75% | 7.48% | 5.16% |
ABBV AbbVie Inc. | 4.43% | 33.08% | 18.86% | -0.23% | 24.01% | 32.43% | 27.72% | 1.47% | -0.96% | 60.07% |
Correlation
The correlation between IONS and ABBV is 0.32, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.32 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.20 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.19 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.25 |
Correlation (All Time) Calculated using the full available price history since Jan 2, 2013 | 0.28 |
The correlation between IONS and ABBV shifts across timeframes, from 0.19 (5 years) to 0.32 (1 year), reflecting how their relationship changes across market environments.
Fundamentals
IONS:
$12.53B
ABBV:
$416.46B
IONS:
-$1.95
ABBV:
$2.05
IONS:
12.03
ABBV:
6.63
IONS:
25.50
ABBV:
15.14
IONS:
$1.06B
ABBV:
$62.82B
IONS:
$1.04B
ABBV:
$46.15B
IONS:
$4.54B
ABBV:
$17.96B
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Return for Risk
IONS vs. ABBV — Risk / Return Rank
IONS
ABBV
IONS vs. ABBV - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Ionis Pharmaceuticals, Inc. (IONS) and AbbVie Inc. (ABBV). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| IONS | ABBV | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.92 | ||
| Sortino ratioReturn per unit of downside risk | +2.22 | ||
| Omega ratioGain probability vs. loss probability | 1.49 | 1.24 | +0.25 |
| Calmar ratioReturn relative to maximum drawdown | 5.26 | 1.85 | +3.41 |
| Martin ratioReturn relative to average drawdown | 12.39 | 4.11 | +8.28 |
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Drawdowns
IONS vs. ABBV - Drawdown Comparison
The maximum IONS drawdown since its inception was -91.42%, which is greater than ABBV's maximum drawdown of -45.09%. Use the drawdown chart below to compare losses from any high point for IONS and ABBV.
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Drawdown Indicators
| IONS | ABBV | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -91.42% | -45.09% | -46.33% |
Max Drawdown (1Y)Largest decline over 1 year | -19.45% | -17.32% | -2.13% |
Max Drawdown (3Y)Largest decline over 3 years | -52.36% | -20.74% | -31.62% |
Max Drawdown (5Y)Largest decline over 5 years | -52.36% | -21.92% | -30.44% |
Max Drawdown (10Y)Largest decline over 10 years | -70.39% | -45.09% | -25.30% |
Current DrawdownCurrent decline from peak | -12.15% | -1.66% | -10.49% |
Average DrawdownAverage peak-to-trough decline | -52.35% | -10.70% | -41.65% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 8.24% | 7.78% | +0.46% |
Volatility
IONS vs. ABBV - Volatility Comparison
The current volatility for Ionis Pharmaceuticals, Inc. (IONS) is 6.42%, while AbbVie Inc. (ABBV) has a volatility of 9.26%. This indicates that IONS experiences smaller price fluctuations and is considered to be less risky than ABBV based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| IONS | ABBV | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 6.42% | 9.26% | -2.84% |
Volatility (6M)Calculated over the trailing 6-month period | 20.05% | 19.11% | +0.94% |
Volatility (1Y)Calculated over the trailing 1-year period | 46.63% | 25.23% | +21.40% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 42.20% | 23.12% | +19.08% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 46.17% | 25.83% | +20.34% |
Dividends
IONS vs. ABBV - Dividend Comparison
IONS has not paid dividends to shareholders, while ABBV's dividend yield for the trailing twelve months is around 2.87%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ABBV AbbVie Inc. | 2.87% | 2.87% | 3.49% | 3.82% | 3.49% | 3.84% | 4.41% | 4.83% | 3.89% | 2.65% | 3.64% | 3.41% |
IONS Ionis Pharmaceuticals, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
Financials
IONS vs. ABBV - Financials Comparison
This section allows you to compare key financial metrics between Ionis Pharmaceuticals, Inc. and AbbVie Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
IONS vs. ABBV - Profitability Comparison
IONS - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Ionis Pharmaceuticals, Inc. reported a gross profit of 243.11M and revenue of 246.09M. Therefore, the gross margin over that period was 98.8%.
ABBV - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, AbbVie Inc. reported a gross profit of 12.53B and revenue of 15.00B. Therefore, the gross margin over that period was 83.5%.
IONS - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Ionis Pharmaceuticals, Inc. reported an operating income of -117.42M and revenue of 246.09M, resulting in an operating margin of -47.7%.
ABBV - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, AbbVie Inc. reported an operating income of 4.73B and revenue of 15.00B, resulting in an operating margin of 31.6%.
IONS - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Ionis Pharmaceuticals, Inc. reported a net income of -92.53M and revenue of 246.09M, resulting in a net margin of -37.6%.
ABBV - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, AbbVie Inc. reported a net income of 699.00M and revenue of 15.00B, resulting in a net margin of 4.7%.
Frequently Asked Questions
IONS and ABBV have a correlation of 0.32, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
ABBV has higher volatility (9.26%) compared to IONS (6.42%). In terms of maximum drawdown, IONS dropped -91.42% vs ABBV's -45.09%.
IONS currently has the higher Sharpe Ratio (2.19 vs 1.27), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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