IONS vs. WVE
Compare and contrast key facts about Ionis Pharmaceuticals, Inc. (IONS) and Wave Life Sciences Ltd. (WVE).
Performance
IONS vs. WVE - Performance Comparison
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IONS vs. WVE - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
IONS Ionis Pharmaceuticals, Inc. | -5.08% | 126.29% | -30.90% | 33.94% | 24.12% | -46.18% | -6.41% | 11.75% | 7.48% | 5.16% |
WVE Wave Life Sciences Ltd. | -57.35% | 37.43% | 144.95% | -27.86% | 122.93% | -60.10% | -1.81% | -80.93% | 19.77% | 34.23% |
Fundamentals
IONS:
$12.16B
WVE:
$1.31B
IONS:
-$2.26
WVE:
-$1.20
IONS:
13.40
WVE:
28.95
IONS:
24.88
WVE:
2.52
IONS:
$943.38M
WVE:
$42.73M
IONS:
$927.39M
WVE:
$21.12M
IONS:
-$288.11M
WVE:
-$206.29M
Returns By Period
In the year-to-date period, IONS achieves a -5.08% return, which is significantly higher than WVE's -57.35% return. Over the past 10 years, IONS has outperformed WVE with an annualized return of 6.23%, while WVE has yielded a comparatively lower -6.17% annualized return.
IONS
- 1D
- 3.54%
- 1M
- -7.47%
- YTD
- -5.08%
- 6M
- 14.78%
- 1Y
- 148.89%
- 3Y*
- 28.08%
- 5Y*
- 10.76%
- 10Y*
- 6.23%
WVE
- 1D
- 9.52%
- 1M
- -47.95%
- YTD
- -57.35%
- 6M
- -0.96%
- 1Y
- -10.27%
- 3Y*
- 18.75%
- 5Y*
- 3.55%
- 10Y*
- -6.17%
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Return for Risk
IONS vs. WVE — Risk / Return Rank
IONS
WVE
IONS vs. WVE - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Ionis Pharmaceuticals, Inc. (IONS) and Wave Life Sciences Ltd. (WVE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| IONS | WVE | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | 2.96 | -0.06 | +3.02 |
Sortino ratioReturn per unit of downside risk | 4.28 | 1.26 | +3.02 |
Omega ratioGain probability vs. loss probability | 1.57 | 1.20 | +0.37 |
Calmar ratioReturn relative to maximum drawdown | 7.25 | -0.22 | +7.48 |
Martin ratioReturn relative to average drawdown | 25.04 | -0.60 | +25.64 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| IONS | WVE | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 2.96 | -0.06 | +3.02 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.25 | 0.03 | +0.22 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.13 | -0.06 | +0.19 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.10 | -0.07 | +0.18 |
Correlation
The correlation between IONS and WVE is 0.26, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.
Dividends
IONS vs. WVE - Dividend Comparison
Neither IONS nor WVE has paid dividends to shareholders.
Drawdowns
IONS vs. WVE - Drawdown Comparison
The maximum IONS drawdown since its inception was -91.42%, smaller than the maximum WVE drawdown of -97.77%. Use the drawdown chart below to compare losses from any high point for IONS and WVE.
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Drawdown Indicators
| IONS | WVE | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -91.42% | -97.77% | +6.35% |
Max Drawdown (1Y)Largest decline over 1 year | -19.45% | -70.91% | +51.46% |
Max Drawdown (5Y)Largest decline over 5 years | -52.36% | -83.53% | +31.17% |
Max Drawdown (10Y)Largest decline over 10 years | -70.39% | -97.77% | +27.38% |
Current DrawdownCurrent decline from peak | -13.19% | -86.87% | +73.68% |
Average DrawdownAverage peak-to-trough decline | -52.59% | -64.37% | +11.78% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 5.63% | 26.68% | -21.05% |
Volatility
IONS vs. WVE - Volatility Comparison
The current volatility for Ionis Pharmaceuticals, Inc. (IONS) is 10.99%, while Wave Life Sciences Ltd. (WVE) has a volatility of 70.76%. This indicates that IONS experiences smaller price fluctuations and is considered to be less risky than WVE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| IONS | WVE | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 10.99% | 70.76% | -59.77% |
Volatility (6M)Calculated over the trailing 6-month period | 22.34% | 124.74% | -102.40% |
Volatility (1Y)Calculated over the trailing 1-year period | 50.77% | 171.05% | -120.28% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 42.73% | 114.66% | -71.93% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 48.55% | 98.93% | -50.38% |
Financials
IONS vs. WVE - Financials Comparison
This section allows you to compare key financial metrics between Ionis Pharmaceuticals, Inc. and Wave Life Sciences Ltd.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities