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iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) Alternatives

ETF · Currency in CAD · Last updated Jun 4, 2026

iShares Genomics Immunology and Healthcare Index ETF seeks to replicate an index of global companies that may benefit from long-term growth and innovation in genomics, immunology, and bioengineering.

iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with XDNA.TO. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.

Cheapest Alternatives to XDNA.TO

XDNA.TO charges 0.44% annually. There is 1 ETF in the Health & Biotech Equities category with a lower expense ratio, going as low as 0.39%.

SymbolNameExpense RatioAUMInception
ZUH.TO
BMO Equal Weight US Health Care Hedged to CAD Inde...0.39%167.47MMay 2010XDNA.TO vs ZUH.TO
LMAX.TO
Hamilton Healthcare Yield Maximizer ETF0.65%199.50MFeb 2024XDNA.TO vs LMAX.TO
XHC.TO
iShares Global Healthcare Index ETF (CAD-Hedged)0.66%484.30MApr 2011XDNA.TO vs XHC.TO
HHL.TO
Harvest Healthcare Leaders Income ETF0.85%1.85BMar 2020XDNA.TO vs HHL.TO
HHLE.TO
Harvest Healthcare Leaders Enhanced Income ETF - C...0.85%102.46MOct 2022XDNA.TO vs HHLE.TO

Best Risk-Adjusted Alternatives to XDNA.TO

XDNA.TO has a PortfoliosLab risk / return rank of 59. No ETFs in the Health & Biotech Equities category have higher risk-adjusted ranks; the top alternatives shown here go as high as 18.

SymbolNameRisk / Return RankAUMInception
ZUH.TO
BMO Equal Weight US Health Care Hedged to CAD Inde...
18
167.47MMay 2010XDNA.TO vs ZUH.TO
XHC.TO
iShares Global Healthcare Index ETF (CAD-Hedged)
17
484.30MApr 2011XDNA.TO vs XHC.TO
LMAX.TO
Hamilton Healthcare Yield Maximizer ETF
17
199.50MFeb 2024XDNA.TO vs LMAX.TO
HHL.TO
Harvest Healthcare Leaders Income ETF
13
1.85BMar 2020XDNA.TO vs HHL.TO
HHLE.TO
Harvest Healthcare Leaders Enhanced Income ETF - C...
12
102.46MOct 2022XDNA.TO vs HHLE.TO

Top Performing XDNA.TO Alternatives (YTD)

XDNA.TO is at 10.45% YTD. No ETFs in the Health & Biotech Equities category have higher YTD returns; the top-performing alternatives shown here go as high as -3.50%.

SymbolNameYTD ReturnAUMInception
ZUH.TO
BMO Equal Weight US Health Care Hedged to CAD Inde...
-3.50%
167.47MMay 2010XDNA.TO vs ZUH.TO
LMAX.TO
Hamilton Healthcare Yield Maximizer ETF
-4.95%
199.50MFeb 2024XDNA.TO vs LMAX.TO
XHC.TO
iShares Global Healthcare Index ETF (CAD-Hedged)
-5.65%
484.30MApr 2011XDNA.TO vs XHC.TO
HHL.TO
Harvest Healthcare Leaders Income ETF
-8.20%
1.85BMar 2020XDNA.TO vs HHL.TO
HHLE.TO
Harvest Healthcare Leaders Enhanced Income ETF - C...
-10.95%
102.46MOct 2022XDNA.TO vs HHLE.TO

Lowest Volatility Alternatives to XDNA.TO

XDNA.TO has 24.71% 1-year volatility. There are 5 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 13.23%.

SymbolNameVolatility 1YAUMInception
LMAX.TO
Hamilton Healthcare Yield Maximizer ETF13.23%199.50MFeb 2024XDNA.TO vs LMAX.TO
XHC.TO
iShares Global Healthcare Index ETF (CAD-Hedged)14.34%484.30MApr 2011XDNA.TO vs XHC.TO
HHL.TO
Harvest Healthcare Leaders Income ETF14.40%1.85BMar 2020XDNA.TO vs HHL.TO
ZUH.TO
BMO Equal Weight US Health Care Hedged to CAD Inde...15.27%167.47MMay 2010XDNA.TO vs ZUH.TO
HHLE.TO
Harvest Healthcare Leaders Enhanced Income ETF - C...18.44%102.46MOct 2022XDNA.TO vs HHLE.TO

Lowest Drawdown Alternatives to XDNA.TO

XDNA.TO has a 1-year max drawdown of -8.64%. No ETFs in the Health & Biotech Equities category have shallower 1-year drawdowns; the lowest-drawdown alternatives shown here go as shallow as -10.79%.

SymbolNameMax Drawdown 1YAUMInception
XHC.TO
iShares Global Healthcare Index ETF (CAD-Hedged)
-10.79%
484.30MApr 2011XDNA.TO vs XHC.TO
ZUH.TO
BMO Equal Weight US Health Care Hedged to CAD Inde...
-11.59%
167.47MMay 2010XDNA.TO vs ZUH.TO
LMAX.TO
Hamilton Healthcare Yield Maximizer ETF
-12.16%
199.50MFeb 2024XDNA.TO vs LMAX.TO
HHL.TO
Harvest Healthcare Leaders Income ETF
-12.88%
1.85BMar 2020XDNA.TO vs HHL.TO
HHLE.TO
Harvest Healthcare Leaders Enhanced Income ETF - C...
-16.36%
102.46MOct 2022XDNA.TO vs HHLE.TO

Other ETFs from iShares

The 10 most viewed iShares ETFs shown here include XEQT.TO, XDIV.TO, XEI.TO and span 8 categories. AUM among these funds goes as high as $30B.

SymbolNameCategoryRisk / Return RankYTD ReturnAUMInception
XEQT.TO
iShares Core Equity ETF PortfolioGlobal Equities
75
12.29%
18.41BAug 2019XDNA.TO vs XEQT.TO
XDIV.TO
iShares Core MSCI Canadian Quality Dividend Index ...Dividend, Large Cap Value Equities
98
19.17%
5.25BJun 2017XDNA.TO vs XDIV.TO
XEI.TO
iShares S&P/TSX Composite High Dividend Index ETFCanada Equities
98
22.21%
4.02BApr 2011XDNA.TO vs XEI.TO
XIC.TO
iShares Core S&P/TSX Capped Composite Index ETFCanada Equities
80
10.75%
29.66BFeb 2001XDNA.TO vs XIC.TO
XIU.TO
iShares S&P/TSX 60 Index ETFCanada Equities
82
10.14%
22.52BSep 1999XDNA.TO vs XIU.TO
XQQ.TO
iShares NASDAQ 100 Index ETF (CAD-Hedged)Nasdaq-100
66
19.81%
5.56BMay 2011XDNA.TO vs XQQ.TO
XEF.TO
iShares Core MSCI EAFE IMI Index ETFForeign Large Cap Equities
47
9.95%
21.46BApr 2013XDNA.TO vs XEF.TO
XGRO.TO
iShares Core Growth ETF PortfolioDiversified Portfolio
67
10.38%
4.82BJun 2007XDNA.TO vs XGRO.TO
XUS.TO
iShares Core S&P 500 Index ETFS&P 500
73
12.21%
12.60BApr 2013XDNA.TO vs XUS.TO
XAW.TO
iShares Core MSCI All Country World ex Canada Inde...Global Equities
76
13.70%
4.25BFeb 2015XDNA.TO vs XAW.TO

Often Compared With XDNA.TO

Investors most often compare XDNA.TO with XSP.TO. These 1 comparison targets span 1 categories, based on PortfoliosLab usage data.

SymbolNameCategoryRisk / Return RankYTD ReturnAUMInception
XSP.TO
iShares Core S&P 500 Index ETF (CAD-Hedged)S&P 500
61
9.64%
15.61BMay 2001XDNA.TO vs XSP.TO

Compare XDNA.TO with Any Fund or Stock

Compare XDNA.TO with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.

 

Diversifiers

Pair XDNA.TO with funds that move differently

iShares Genomics Immunology and Healthcare Index ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to XDNA.TO.

Explore XDNA.TO Diversifiers