XDNA.TO vs. HHLE.TO
XDNA.TO (iShares Genomics Immunology and Healthcare Index ETF) and HHLE.TO (Harvest Healthcare Leaders Enhanced Income ETF - Class A Units) are both Health & Biotech Equities funds. XDNA.TO is passively managed, while HHLE.TO is actively managed. Over the past 3 years, XDNA.TO returned 7.28%/yr vs 3.15%/yr for HHLE.TO. At a 0.18 correlation, their price movements are largely independent. XDNA.TO charges 0.44%/yr vs 0.85%/yr for HHLE.TO.
Performance
XDNA.TO vs. HHLE.TO - Performance Comparison
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Returns By Period
In the year-to-date period, XDNA.TO achieves a 10.45% return, which is significantly higher than HHLE.TO's -10.95% return.
XDNA.TO
- 1D
- -1.95%
- 1M
- -1.11%
- YTD
- 10.45%
- 6M
- 9.39%
- 1Y
- 40.18%
- 3Y*
- 7.28%
- 5Y*
- —
- 10Y*
- —
HHLE.TO
- 1D
- 0.90%
- 1M
- 0.01%
- YTD
- -10.95%
- 6M
- -10.74%
- 1Y
- 4.08%
- 3Y*
- 3.15%
- 5Y*
- —
- 10Y*
- —
XDNA.TO vs. HHLE.TO - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
XDNA.TO iShares Genomics Immunology and Healthcare Index ETF | 10.45% | 12.10% | 5.54% | -7.84% | -5.28% |
HHLE.TO Harvest Healthcare Leaders Enhanced Income ETF - Class A Units | -10.95% | 11.85% | 3.28% | 7.14% | 5.96% |
Correlation
The correlation between XDNA.TO and HHLE.TO is 0.24, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.24 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.19 |
Correlation (All Time) Calculated using the full available price history since Oct 26, 2022 | 0.18 |
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Return for Risk
XDNA.TO vs. HHLE.TO — Risk / Return Rank
XDNA.TO
HHLE.TO
XDNA.TO vs. HHLE.TO - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) and Harvest Healthcare Leaders Enhanced Income ETF - Class A Units (HHLE.TO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| XDNA.TO | HHLE.TO | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +1.42 | ||
| Sortino ratioReturn per unit of downside risk | +1.99 | ||
| Omega ratioGain probability vs. loss probability | 1.30 | 1.05 | +0.24 |
| Calmar ratioReturn relative to maximum drawdown | 4.67 | 0.25 | +4.42 |
| Martin ratioReturn relative to average drawdown | 10.95 | 0.62 | +10.32 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| XDNA.TO | HHLE.TO | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 1.65 | 0.22 | +1.42 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.04 | 0.27 | -0.22 |
Drawdowns
XDNA.TO vs. HHLE.TO - Drawdown Comparison
The maximum XDNA.TO drawdown since its inception was -45.90%, which is greater than HHLE.TO's maximum drawdown of -20.60%. Use the drawdown chart below to compare losses from any high point for XDNA.TO and HHLE.TO.
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Drawdown Indicators
| XDNA.TO | HHLE.TO | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -45.90% | -20.60% | -25.30% |
Max Drawdown (1Y)Largest decline over 1 year | -8.64% | -16.36% | +7.72% |
Max Drawdown (3Y)Largest decline over 3 years | -28.29% | -20.60% | -7.69% |
Current DrawdownCurrent decline from peak | -8.95% | -14.87% | +5.92% |
Average DrawdownAverage peak-to-trough decline | -23.55% | -6.56% | -16.99% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 3.68% | 6.57% | -2.89% |
Volatility
XDNA.TO vs. HHLE.TO - Volatility Comparison
The current volatility for iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) is 6.47%, while Harvest Healthcare Leaders Enhanced Income ETF - Class A Units (HHLE.TO) has a volatility of 7.61%. This indicates that XDNA.TO experiences smaller price fluctuations and is considered to be less risky than HHLE.TO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| XDNA.TO | HHLE.TO | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 6.47% | 7.61% | -1.14% |
Volatility (6M)Calculated over the trailing 6-month period | 18.03% | 13.23% | +4.80% |
Volatility (1Y)Calculated over the trailing 1-year period | 24.71% | 18.44% | +6.27% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 25.32% | 16.62% | +8.70% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 25.32% | 16.62% | +8.70% |
XDNA.TO vs. HHLE.TO - Expense Ratio Comparison
XDNA.TO has a 0.44% expense ratio, which is lower than HHLE.TO's 0.85% expense ratio.
Dividends
XDNA.TO vs. HHLE.TO - Dividend Comparison
XDNA.TO's dividend yield for the trailing twelve months is around 0.39%, less than HHLE.TO's 14.25% yield.
| Position | TTM | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
HHLE.TO Harvest Healthcare Leaders Enhanced Income ETF - Class A Units | 14.25% | 12.01% | 11.76% | 10.81% | 1.73% |
XDNA.TO iShares Genomics Immunology and Healthcare Index ETF | 0.39% | 0.43% | 0.32% | 0.25% | 0.32% |
Frequently Asked Questions
XDNA.TO and HHLE.TO have a correlation of 0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
On fees, XDNA.TO is cheaper at 0.44% per year. The better choice depends on whether you care most about return, fees, risk, or income.
XDNA.TO is cheaper with a 0.44% expense ratio, compared with 0.85% for HHLE.TO.
They also come from different issuers: iShares and Harvest. Their fees differ too: 0.44% for XDNA.TO and 0.85% for HHLE.TO.
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