XDNA.TO vs. IBB
XDNA.TO (iShares Genomics Immunology and Healthcare Index ETF) and IBB (iShares Nasdaq Biotechnology ETF) are both Health & Biotech Equities funds from iShares - XDNA.TO tracks the NYSE FactSet Global Genomics and Immuno Biopharma Index while IBB tracks the NASDAQ Biotechnology Index. Both are passively managed. Over the past 3 years, XDNA.TO returned 14.14%/yr vs 16.21%/yr for IBB. At a 0.20 correlation, their price movements are largely independent. XDNA.TO charges 0.44%/yr vs 0.47%/yr for IBB.
Performance
XDNA.TO vs. IBB - Performance Comparison
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Different Trading Currencies
XDNA.TO is traded in CAD, while IBB is traded in USD. To make them comparable, the IBB values have been converted to CAD using the latest available exchange rates.
Returns By Period
In the year-to-date period, XDNA.TO achieves a 28.27% return, which is significantly higher than IBB's 15.20% return.
XDNA.TO
- 1D
- -0.71%
- 1M
- 10.45%
- 6M
- 16.34%
- YTD
- 28.27%
- 1Y
- 59.77%
- 3Y*
- 14.14%
- 5Y*
- —
- 10Y*
- —
IBB
- 1D
- -0.31%
- 1M
- 10.91%
- 6M
- 12.43%
- YTD
- 15.20%
- 1Y
- 48.22%
- 3Y*
- 16.21%
- 5Y*
- 5.91%
- 10Y*
- 8.74%
XDNA.TO vs. IBB - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
XDNA.TO iShares Genomics Immunology and Healthcare Index ETF | 28.27% | 12.10% | 5.54% | -7.84% | -14.85% |
IBB iShares Nasdaq Biotechnology ETF | 15.20% | 22.14% | 5.85% | 1.29% | 15.99% |
Correlation
The correlation between XDNA.TO and IBB is 0.36, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.36 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.24 |
Correlation (All Time) Calculated using the full available price history since May 4, 2022 | 0.20 |
The correlation between XDNA.TO and IBB shifts across timeframes, from 0.20 (all time) to 0.36 (1 year), reflecting how their relationship changes across market environments.
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Return for Risk
XDNA.TO vs. IBB — Risk / Return Rank
XDNA.TO
IBB
XDNA.TO vs. IBB - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) and iShares Nasdaq Biotechnology ETF (IBB). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| XDNA.TO | IBB | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.03 | ||
| Sortino ratioReturn per unit of downside risk | -0.03 | ||
| Omega ratioGain probability vs. loss probability | 1.39 | 1.38 | +0.01 |
| Calmar ratioReturn relative to maximum drawdown | 6.95 | 5.01 | +1.95 |
| Martin ratioReturn relative to average drawdown | 15.82 | 12.93 | +2.89 |
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Drawdowns
XDNA.TO vs. IBB - Drawdown Comparison
The maximum XDNA.TO drawdown since its inception was -45.90%, which is greater than IBB's maximum drawdown of -39.09%. Use the drawdown chart below to compare losses from any high point for XDNA.TO and IBB.
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Drawdown Indicators
| XDNA.TO | IBB | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -45.90% | -39.09% | -6.81% |
Max Drawdown (1Y)Largest decline over 1 year | -8.64% | -9.68% | +1.04% |
Max Drawdown (3Y)Largest decline over 3 years | -28.29% | -22.65% | -5.64% |
Max Drawdown (5Y)Largest decline over 5 years | — | -38.88% | — |
Max Drawdown (10Y)Largest decline over 10 years | — | -38.88% | — |
Current DrawdownCurrent decline from peak | -7.51% | -5.55% | -1.96% |
Average DrawdownAverage peak-to-trough decline | -22.98% | -16.58% | -6.40% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 3.79% | 3.74% | +0.05% |
Volatility
XDNA.TO vs. IBB - Volatility Comparison
iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) has a higher volatility of 7.90% compared to iShares Nasdaq Biotechnology ETF (IBB) at 6.25%. This indicates that XDNA.TO's price experiences larger fluctuations and is considered to be riskier than IBB based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| XDNA.TO | IBB | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 7.90% | 6.25% | +1.65% |
Volatility (6M)Calculated over the trailing 6-month period | 18.84% | 16.41% | +2.43% |
Volatility (1Y)Calculated over the trailing 1-year period | 25.66% | 21.00% | +4.66% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 25.41% | 22.93% | +2.48% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 25.41% | 24.06% | +1.35% |
XDNA.TO vs. IBB - Expense Ratio Comparison
XDNA.TO has a 0.44% expense ratio, which is lower than IBB's 0.47% expense ratio.
Dividends
XDNA.TO vs. IBB - Dividend Comparison
XDNA.TO's dividend yield for the trailing twelve months is around 0.25%, more than IBB's 0.22% yield.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
IBB iShares Nasdaq Biotechnology ETF | 0.22% | 0.23% | 0.29% | 0.26% | 0.31% | 0.21% | 0.21% | 0.33% | 0.20% | 0.30% | 0.19% | 0.03% |
XDNA.TO iShares Genomics Immunology and Healthcare Index ETF | 0.25% | 0.43% | 0.32% | 0.25% | 0.32% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
Frequently Asked Questions
XDNA.TO and IBB have a correlation of 0.36, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
On fees, XDNA.TO is cheaper at 0.44% per year. The better choice depends on whether you care most about return, fees, risk, or income.
XDNA.TO is cheaper with a 0.44% expense ratio, compared with 0.47% for IBB.
XDNA.TO tracks NYSE FactSet Global Genomics and Immuno Biopharma Index, while IBB tracks NASDAQ Biotechnology Index. Their fees differ too: 0.44% for XDNA.TO and 0.47% for IBB.
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