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XDNA.TO vs. XUS.TO
Performance
Return for Risk
Drawdowns
Volatility
Dividends

XDNA.TO vs. XUS.TO

Last updated Jun 4, 2026

XDNA.TO (iShares Genomics Immunology and Healthcare Index ETF) and XUS.TO (iShares Core S&P 500 Index ETF) are both exchange-traded funds - XDNA.TO is a Health & Biotech Equities fund tracking the NYSE FactSet Global Genomics and Immuno Biopharma Index, while XUS.TO is a S&P 500 fund tracking the S&P 500 Index. Both are passively managed. Over the past 3 years, XDNA.TO returned 7.28%/yr vs 23.52%/yr for XUS.TO. At a 0.18 correlation, their price movements are largely independent. XDNA.TO charges 0.44%/yr vs 0.09%/yr for XUS.TO.

Performance

XDNA.TO vs. XUS.TO - Performance Comparison

The chart below illustrates the hypothetical performance of a CA$10,000 investment in iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) and iShares Core S&P 500 Index ETF (XUS.TO). The values are adjusted to include any dividend payments, if applicable.

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Returns By Period

In the year-to-date period, XDNA.TO achieves a 10.45% return, which is significantly lower than XUS.TO's 12.21% return.

XDNA.TO

1D
-1.95%
1M
-1.11%
YTD
10.45%
6M
9.39%
1Y
40.18%
3Y*
7.28%
5Y*
—
10Y*
—

XUS.TO

1D
-0.31%
1M
7.22%
YTD
12.21%
6M
10.39%
1Y
29.30%
3Y*
23.52%
5Y*
16.78%
10Y*
15.98%
*Multi-year figures are annualized to reflect compound growth (CAGR)

XDNA.TO vs. XUS.TO - Yearly Performance Comparison

2026 (YTD)2025202420232022
XDNA.TO
iShares Genomics Immunology and Healthcare Index ETF		10.45%12.10%5.54%-7.84%-13.38%
XUS.TO
iShares Core S&P 500 Index ETF		12.21%12.19%35.16%23.31%-2.01%

Correlation

The correlation between XDNA.TO and XUS.TO is 0.26, which is low. Their price movements are largely independent, making them effective diversification partners.

Correlation
Correlation (1Y)
Calculated over the trailing 1-year period

0.26

Correlation (3Y)
Calculated over the trailing 3-year period

0.19

Correlation (All Time)
Calculated using the full available price history since May 4, 2022

0.18

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iShares Genomics Immunology and Healthcare Index ETF

iShares Core S&P 500 Index ETF

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Often compared with XUS.TO:
XUS.TO vs. XSP.TOXUS.TO vs. XEQT.TOXUS.TO vs. XUU.TOXUS.TO vs. ZSP.TOXUS.TO vs. VOOXUS.TO vs. XEF.TOXUS.TO vs. HXS.TO

Return for Risk

XDNA.TO vs. XUS.TO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.
XDNA.TO
XDNA.TO Risk / Return Rank: 5959
Overall Rank
XDNA.TO Sharpe Ratio Rank: 4949
Sharpe Ratio Rank
XDNA.TO Sortino Ratio Rank: 5151
Sortino Ratio Rank
XDNA.TO Omega Ratio Rank: 4848
Omega Ratio Rank
XDNA.TO Calmar Ratio Rank: 8585
Calmar Ratio Rank
XDNA.TO Martin Ratio Rank: 6262
Martin Ratio Rank
XUS.TO
XUS.TO Risk / Return Rank: 7373
Overall Rank
XUS.TO Sharpe Ratio Rank: 7777
Sharpe Ratio Rank
XUS.TO Sortino Ratio Rank: 7575
Sortino Ratio Rank
XUS.TO Omega Ratio Rank: 7777
Omega Ratio Rank
XUS.TO Calmar Ratio Rank: 6767
Calmar Ratio Rank
XUS.TO Martin Ratio Rank: 6868
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XDNA.TO vs. XUS.TO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) and iShares Core S&P 500 Index ETF (XUS.TO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

XDNA.TOXUS.TODifference
Sharpe ratioReturn per unit of total volatility
1.65
2.55

-0.90

Sortino ratioReturn per unit of downside risk
2.45
3.47

-1.02

Omega ratioGain probability vs. loss probability

1.30

1.47

-0.17

Calmar ratioReturn relative to maximum drawdown

4.67

3.41

+1.26

Martin ratioReturn relative to average drawdown

10.95

12.94

-1.99

Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

XDNA.TO vs. XUS.TO - Sharpe Ratio Comparison

The current XDNA.TO Sharpe Ratio is 1.65, which is lower than the XUS.TO Sharpe Ratio of 2.55. The chart below compares the historical Sharpe Ratios of XDNA.TO and XUS.TO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

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Sharpe Ratios by Period

XDNA.TOXUS.TODifference

Sharpe Ratio (1Y)

Calculated over the trailing 1-year period

1.65

2.55

-0.90

Sharpe Ratio (5Y)

Calculated over the trailing 5-year period

—

1.13

—

Sharpe Ratio (10Y)

Calculated over the trailing 10-year period

—

0.98

—

Sharpe Ratio (All Time)

Calculated using the full available price history

0.04

1.08

-1.04

Drawdowns

XDNA.TO vs. XUS.TO - Drawdown Comparison

The maximum XDNA.TO drawdown since its inception was -45.90%, which is greater than XUS.TO's maximum drawdown of -27.23%. Use the drawdown chart below to compare losses from any high point for XDNA.TO and XUS.TO.

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Drawdown Indicators

XDNA.TOXUS.TODifference

Max Drawdown

Largest peak-to-trough decline

-45.90%

-27.23%

-18.67%

Max Drawdown (1Y)

Largest decline over 1 year

-8.64%

-8.63%

-0.01%

Max Drawdown (3Y)

Largest decline over 3 years

-28.29%

-18.96%

-9.33%

Max Drawdown (5Y)

Largest decline over 5 years

—

-21.85%

—

Max Drawdown (10Y)

Largest decline over 10 years

—

-27.23%

—

Current Drawdown

Current decline from peak

-8.95%

-0.31%

-8.64%

Average Drawdown

Average peak-to-trough decline

-23.55%

-3.46%

-20.09%

Ulcer Index

Depth and duration of drawdowns from previous peaks

3.68%

2.27%

+1.41%

Volatility

XDNA.TO vs. XUS.TO - Volatility Comparison

iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) has a higher volatility of 6.47% compared to iShares Core S&P 500 Index ETF (XUS.TO) at 3.19%. This indicates that XDNA.TO's price experiences larger fluctuations and is considered to be riskier than XUS.TO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

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Volatility by Period

XDNA.TOXUS.TODifference

Volatility (1M)

Calculated over the trailing 1-month period

6.47%

3.19%

+3.28%

Volatility (6M)

Calculated over the trailing 6-month period

18.03%

8.66%

+9.37%

Volatility (1Y)

Calculated over the trailing 1-year period

24.71%

11.58%

+13.13%

Volatility (5Y)

Calculated over the trailing 5-year period, annualized

25.32%

14.92%

+10.40%

Volatility (10Y)

Calculated over the trailing 10-year period, annualized

25.32%

16.48%

+8.84%

XDNA.TO vs. XUS.TO - Expense Ratio Comparison

XDNA.TO has a 0.44% expense ratio, which is higher than XUS.TO's 0.09% expense ratio.

Dividends

XDNA.TO vs. XUS.TO - Dividend Comparison

XDNA.TO's dividend yield for the trailing twelve months is around 0.39%, less than XUS.TO's 1.12% yield.

PositionTTM20252024202320222021202020192018201720162015
XDNA.TO
iShares Genomics Immunology and Healthcare Index ETF		0.39%0.43%0.32%0.25%0.32%0.00%0.00%0.00%0.00%0.00%0.00%0.00%
XUS.TO
iShares Core S&P 500 Index ETF		1.12%1.26%1.03%1.22%1.38%0.99%1.35%2.02%1.77%1.48%1.66%1.70%

Frequently Asked Questions

XDNA.TO and XUS.TO have a correlation of 0.26, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

On fees, XUS.TO is cheaper at 0.09% per year. The better choice depends on whether you care most about return, fees, risk, or income.

XUS.TO is cheaper with a 0.09% expense ratio, compared with 0.44% for XDNA.TO.

XDNA.TO is categorized as Health & Biotech Equities, while XUS.TO is S&P 500. XDNA.TO tracks NYSE FactSet Global Genomics and Immuno Biopharma Index, while XUS.TO tracks S&P 500 Index. Their fees differ too: 0.44% for XDNA.TO and 0.09% for XUS.TO.

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