XDNA.TO vs. XHC.TO
XDNA.TO (iShares Genomics Immunology and Healthcare Index ETF) and XHC.TO (iShares Global Healthcare Index ETF (CAD-Hedged)) are both Health & Biotech Equities funds from iShares - XDNA.TO tracks the NYSE FactSet Global Genomics and Immuno Biopharma Index while XHC.TO tracks the Morningstar Gbl GR CAD. Both are passively managed. Over the past 3 years, XDNA.TO returned 7.28%/yr vs 2.70%/yr for XHC.TO. At a 0.20 correlation, their price movements are largely independent. XDNA.TO charges 0.44%/yr vs 0.66%/yr for XHC.TO.
Performance
XDNA.TO vs. XHC.TO - Performance Comparison
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Returns By Period
In the year-to-date period, XDNA.TO achieves a 10.45% return, which is significantly higher than XHC.TO's -5.65% return.
XDNA.TO
- 1D
- -1.95%
- 1M
- -1.11%
- YTD
- 10.45%
- 6M
- 9.39%
- 1Y
- 40.18%
- 3Y*
- 7.28%
- 5Y*
- —
- 10Y*
- —
XHC.TO
- 1D
- 0.59%
- 1M
- 0.77%
- YTD
- -5.65%
- 6M
- -5.54%
- 1Y
- 7.72%
- 3Y*
- 2.70%
- 5Y*
- 3.54%
- 10Y*
- 6.87%
XDNA.TO vs. XHC.TO - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
XDNA.TO iShares Genomics Immunology and Healthcare Index ETF | 10.45% | 12.10% | 5.54% | -7.84% | -13.38% |
XHC.TO iShares Global Healthcare Index ETF (CAD-Hedged) | -5.65% | 10.91% | 1.22% | 2.14% | 2.38% |
Correlation
The correlation between XDNA.TO and XHC.TO is 0.24, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.24 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.21 |
Correlation (All Time) Calculated using the full available price history since May 4, 2022 | 0.20 |
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Return for Risk
XDNA.TO vs. XHC.TO — Risk / Return Rank
XDNA.TO
XHC.TO
XDNA.TO vs. XHC.TO - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) and iShares Global Healthcare Index ETF (CAD-Hedged) (XHC.TO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| XDNA.TO | XHC.TO | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +1.10 | ||
| Sortino ratioReturn per unit of downside risk | +1.55 | ||
| Omega ratioGain probability vs. loss probability | 1.30 | 1.10 | +0.19 |
| Calmar ratioReturn relative to maximum drawdown | 4.67 | 0.72 | +3.95 |
| Martin ratioReturn relative to average drawdown | 10.95 | 1.76 | +9.18 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| XDNA.TO | XHC.TO | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 1.65 | 0.54 | +1.10 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | — | 0.26 | — |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | — | 0.44 | — |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.04 | 0.67 | -0.63 |
Drawdowns
XDNA.TO vs. XHC.TO - Drawdown Comparison
The maximum XDNA.TO drawdown since its inception was -45.90%, which is greater than XHC.TO's maximum drawdown of -27.28%. Use the drawdown chart below to compare losses from any high point for XDNA.TO and XHC.TO.
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Drawdown Indicators
| XDNA.TO | XHC.TO | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -45.90% | -27.28% | -18.62% |
Max Drawdown (1Y)Largest decline over 1 year | -8.64% | -10.79% | +2.15% |
Max Drawdown (3Y)Largest decline over 3 years | -28.29% | -18.81% | -9.48% |
Max Drawdown (5Y)Largest decline over 5 years | — | -18.81% | — |
Max Drawdown (10Y)Largest decline over 10 years | — | -27.28% | — |
Current DrawdownCurrent decline from peak | -8.95% | -9.76% | +0.81% |
Average DrawdownAverage peak-to-trough decline | -23.55% | -4.85% | -18.70% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 3.68% | 4.39% | -0.71% |
Volatility
XDNA.TO vs. XHC.TO - Volatility Comparison
iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) has a higher volatility of 6.47% compared to iShares Global Healthcare Index ETF (CAD-Hedged) (XHC.TO) at 4.76%. This indicates that XDNA.TO's price experiences larger fluctuations and is considered to be riskier than XHC.TO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| XDNA.TO | XHC.TO | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 6.47% | 4.76% | +1.71% |
Volatility (6M)Calculated over the trailing 6-month period | 18.03% | 10.21% | +7.82% |
Volatility (1Y)Calculated over the trailing 1-year period | 24.71% | 14.34% | +10.37% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 25.32% | 13.87% | +11.45% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 25.32% | 15.75% | +9.57% |
XDNA.TO vs. XHC.TO - Expense Ratio Comparison
XDNA.TO has a 0.44% expense ratio, which is lower than XHC.TO's 0.66% expense ratio.
Dividends
XDNA.TO vs. XHC.TO - Dividend Comparison
XDNA.TO's dividend yield for the trailing twelve months is around 0.39%, less than XHC.TO's 1.98% yield.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
XDNA.TO iShares Genomics Immunology and Healthcare Index ETF | 0.39% | 0.43% | 0.32% | 0.25% | 0.32% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
XHC.TO iShares Global Healthcare Index ETF (CAD-Hedged) | 1.98% | 1.87% | 4.42% | 2.38% | 0.84% | 0.79% | 0.96% | 1.07% | 1.68% | 1.14% | 1.63% | 2.15% |
Frequently Asked Questions
XDNA.TO and XHC.TO have a correlation of 0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
On fees, XDNA.TO is cheaper at 0.44% per year. The better choice depends on whether you care most about return, fees, risk, or income.
XDNA.TO is cheaper with a 0.44% expense ratio, compared with 0.66% for XHC.TO.
XDNA.TO tracks NYSE FactSet Global Genomics and Immuno Biopharma Index, while XHC.TO tracks Morningstar Gbl GR CAD. Their fees differ too: 0.44% for XDNA.TO and 0.66% for XHC.TO.
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