Harbor Health Care ETF (MEDI) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with MEDI. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to MEDI
MEDI charges 0.80% annually. There are 56 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | MEDI vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | MEDI vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | MEDI vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | MEDI vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | MEDI vs GSKH |
Best Risk-Adjusted Alternatives to MEDI
MEDI has a PortfoliosLab risk / return rank of 42. There are 41 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | MEDI vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | MEDI vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | MEDI vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | MEDI vs IHE | |
| iShares Neuroscience and Healthcare ETF | 93 | 5.85M | Aug 2022 | MEDI vs IBRN |
Top Performing MEDI Alternatives (YTD)
MEDI is at 7.43% YTD. There are 34 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 40.11%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 40.11% | 1.31B | Oct 2014 | MEDI vs ARKG | |
| AdvisorShares Psychedelics ETF | 35.29% | 44.37M | Sep 2021 | MEDI vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 34.33% | 6.01M | Dec 2025 | MEDI vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.14% | 57.56M | Dec 2014 | MEDI vs BBC | |
| ALPS Medical Breakthroughs ETF | 27.56% | 213.08M | Dec 2014 | MEDI vs SBIO |
Lowest Volatility Alternatives to MEDI
MEDI has 20.37% 1-year volatility. There are 35 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | MEDI vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | MEDI vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.64% | 10.11M | Jun 2007 | MEDI vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.87% | 16.78M | Jul 2025 | MEDI vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.73% | 982.35K | Apr 2026 | MEDI vs MHIP |
Lowest Drawdown Alternatives to MEDI
MEDI has a 1-year max drawdown of -15.34%. There are 37 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | MEDI vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | MEDI vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | MEDI vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | MEDI vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | MEDI vs IHE |
Other ETFs from Harbor
The 10 most viewed Harbor ETFs shown here include HGER, HAPI, GDIV and span 10 categories. AUM among these funds goes as high as $3B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Harbor Commodity All-Weather Strategy ETF | Commodities | 71 | 25.42% | 3.46B | Feb 2022 | MEDI vs HGER | |
| Harbor Corporate Culture ETF | Large Cap Blend Equities | 59 | 9.39% | 490.42M | Oct 2022 | MEDI vs HAPI | |
| Harbor Dividend Growth Leaders ETF | Large Cap Blend Equities, Dividend | 70 | 12.41% | 233.70M | Jul 2013 | MEDI vs GDIV | |
| Harbor International Compounders ETF | Foreign Large Cap Equities | 12 | -2.08% | 473.84M | Sep 2022 | MEDI vs OSEA | |
| Harbor Long-Short Equity ETF | Long-Short | 71 | 23.57% | 16.40M | Dec 2023 | MEDI vs LSEQ | |
| Harbor Scientific Alpha High-Yield ETF | High Yield Bonds | 67 | 2.38% | 149.42M | Sep 2021 | MEDI vs SIHY | |
| Harbor Long-Term Growers ETF | Large Cap Growth Equities | 23 | 5.29% | 1.18B | Feb 2022 | MEDI vs WINN | |
| Harbor Scientific Alpha Income ETF | Multisector Bonds | 67 | 1.23% | 33.64M | Sep 2021 | MEDI vs SIFI | |
| Harbor Human Capital Factor US Small Cap ETF | Small Cap Blend Equities | 69 | 19.15% | 171.18M | Apr 2023 | MEDI vs HAPS | |
| Harbor Multi-Asset Explorer ETF | Global Allocation | 58 | 4.79% | 11.11M | Sep 2023 | MEDI vs MAPP |
Often Compared With MEDI
Investors most often compare MEDI with MEDX, HDIVX, RSPH. These 20 comparison targets span 12 categories, based on PortfoliosLab usage data.
Compare MEDI with Any Fund or Stock
Compare MEDI with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair MEDI with funds that move differently
Harbor Health Care ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to MEDI.
Explore MEDI Diversifiers