Tema Obesity & Cardiometabolic ETF (HRTS) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with HRTS. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to HRTS
HRTS charges 0.75% annually. There are 48 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | HRTS vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | HRTS vs XLV | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | HRTS vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | HRTS vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | HRTS vs GSKH |
Best Risk-Adjusted Alternatives to HRTS
HRTS has a PortfoliosLab risk / return rank of 63. There are 24 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | HRTS vs BBC | |
| ALPS Medical Breakthroughs ETF | 94 | 213.08M | Dec 2014 | HRTS vs SBIO | |
| First Trust Nasdaq Pharmaceuticals ETF | 94 | 36.36M | Sep 2016 | HRTS vs FTXH | |
| iShares U.S. Pharmaceuticals ETF | 93 | 1.34B | May 2006 | HRTS vs IHE | |
| SPDR S&P Biotech ETF | 93 | 11.10B | Feb 2006 | HRTS vs XBI |
Top Performing HRTS Alternatives (YTD)
HRTS is at 3.50% YTD. There are 48 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 41.35%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 41.35% | 44.37M | Sep 2021 | HRTS vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 38.38% | 1.31B | Oct 2014 | HRTS vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 31.46% | 6.01M | Dec 2025 | HRTS vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 29.44% | 57.56M | Dec 2014 | HRTS vs BBC | |
| SPDR S&P Health Care Services ETF | 26.76% | 204.10M | Sep 2011 | HRTS vs XHS |
Lowest Volatility Alternatives to HRTS
HRTS has 16.50% 1-year volatility. There are 16 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | HRTS vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | HRTS vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.62% | 10.11M | Jun 2007 | HRTS vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 11.06% | 16.78M | Jul 2025 | HRTS vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.54% | 982.35K | Apr 2026 | HRTS vs MHIP |
Lowest Drawdown Alternatives to HRTS
HRTS has a 1-year max drawdown of -11.01%. There are 22 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | HRTS vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | HRTS vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | HRTS vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | HRTS vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | HRTS vs IHE |
Other ETFs from Tema
The 8 most viewed Tema ETFs shown here include VOLT, NASA, CANC and span 10 categories. AUM among these funds goes as high as $1B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Tema Electrification ETF | Global Equities | 79 | 30.34% | 693.48M | Dec 2024 | HRTS vs VOLT | |
| Tema Space Innovators ETF | Aerospace & Defense, Actively Managed | — | — | 1.25B | Mar 2026 | HRTS vs NASA | |
| Tema Oncology ETF | Health & Biotech Equities | 89 | 16.66% | 142.24M | Aug 2023 | HRTS vs CANC | |
| Tema Monopolies and Oligopolies ETF | Large Cap Growth Equities | 39 | 13.48% | 46.36M | May 2023 | HRTS vs TOLL | |
| Tema S&P 500 Historical Weight ETF Strategy | Large Cap Blend Equities, S&P 500 | 76 | 12.78% | 982.04M | Mar 2025 | HRTS vs DSPY | |
| Tema U.S. Manufacturing & Reshoring ETF | Industrials Equities | — | — | 302.19M | May 2023 | HRTS vs WELD | |
| Tema International Durable Quality ETF | Foreign Large Cap Equities | — | 0.58% | — | Sep 2025 | HRTS vs ITOL | |
| Tema Listed Private Managers ETF | Financials Equities | — | — | 0.00 | Oct 2025 | HRTS vs PRVT |
Often Compared With HRTS
Investors most often compare HRTS with OZEM, AIRR, IYH. These 20 comparison targets span 10 categories, based on PortfoliosLab usage data.
Compare HRTS with Any Fund or Stock
Compare HRTS with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair HRTS with funds that move differently
Tema Obesity & Cardiometabolic ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to HRTS.
Explore HRTS Diversifiers